Dr. rer. nat. Lara Schlaffke

MSc. Biology
Haus 4 -1/20c
0234 302 6098
Lara Schlaffke


Forschungsschwerpunkte

Mit Hilfe der funktionellen und strukturellen Bildgebung untersuche ich den Effekt von Lernprozessen auf die Bearbeitung von Stimuli und die strukturellen Veränderungen im Gehirn. Seit einigen Jahren liegt mein Focus auf der quantitativen Bildgebung im Muskel bei neuromuskulären Erkrankungen


Methoden und Forschungsinteressen

• quantitative Bildgebungsmethoden
• Crossmodaler Transfer
• Multimodales Lernen
• Funktionelle Magnetresonanztomographie fMRT
• Diffusions Tensorbildgebung (DTI)
• Voxelbasierte Morphometrie (VBM)


Curriculum Vitae

seit 01/2018
PostDoc AG Neurowissenschaftliche Bildgebung am UK Bergmannsheil

01/2017-12/2018
Research School Plus Gateway Fellow. University Medical Center Utrecht, Niederlande

05/2016-12/2016
PostDoc AG Neurowissenschaftliche Bildgebung am UK Bergmannsheil

04/2016
Promotion (Dr.rer.nat., summa cum laude) in Biologie. Dissertation "Kortikale Plastizität beim Erlernen des Morse Codes-Untersuchungen zum Übergang zwischen perzeptuellem und semantischem Lernen im menschlichen Gehirn"

10/2012-04/2016
Promotionsstudium Neurowissenschaften an der Internationalen Graduiertenschule für Biowissenschaften der Ruhr-Universität Bochum in der AG Neurowissenschaftliche Bildgebung am UK Bergmannsheil

10/2011-10/2012
M.Sc. Biologie an der Ruhr-Universität Bochum
Thema: Kortikale Korrelate der „Theory of mind“ bei Kampf- und Ausdauersportlern
Angefertigt AG Neurowissenschaftliche Bildgebung am UK Bergmannsheil


Publikationen

Queiroz de Paiva JP, Magalhães SC, Moura LM, Sato JR, Amaro E, Sterr A, Schlaffke L, Eckeli AL, Fernandes do Prado G, Conforto AB (2020): Sensorimotor white matter projections and disease severity in primary Restless Legs Syndrome/ Willis-Ekbom Disease: a multimodal DTI analysis. Sleep Med. (in press)https://doi.org/10.1016/j.sleep.2020.05.040.

Otto LAM, van den Pol L, Schlaffke L, Wijngaarde CA, Stam M, Wadmann R, Cuppen I, van Eijk R, Asselman F-L, Bartels B, van der Woude D, Hendrikse J, Froeling M (2020): Quantitative MRI of skeletal muscle in a cross-sectional cohort of Spinal Muscular Atrophy patients type 2-3. NMR Biomed(in press)

Rehmann R, Froeling M, Rohm M, Forsting J, Kley RA, Schmidt-Wilcke T, Karabul N, Tegenthoff M, Vorgerd M, Schlaffke L (2020): Muscle Diffusion tensor imaging reveals changes in non-fat infiltrated muscles in late-onset Pompe disease. Muscle and Nerve (in press)

Wang BA, Schlaffke L, Pleger B (2020): Modulations of insular projections by prior belief mediate the precision of prediction error during tactile learning. J Neurosci 40:3827–3837.

Forsting J, Rehmann R, Froeling M, Vorgerd M, Tegenthoff M, Schlaffke L (2020): Diffusion Tensor Imaging of the Human Thigh: Consideration of DTI-based fiber tracking stop criteria. MAGMA 33:343–355.

Schlaffke L, Friedrich S, Tegenthoff M, Güntürkün O, Genc E, Ocklenburg S (2020): Boom Chack Boom - A multimethod investigation of motor inhibition in professional drummers. Brain Behav 10:e01490.

De Luca A, Schlaffke L, Siero J, Froeling M, Leemans A (2019): On the sensitivity of the diffusion MRI signal to brain activity in response to a motor cortex paradigm. Hum Brain Mapp:1–14.

Schlaffke L, Rehmann R, Rohm M, Otto L, De Luca A, Burakiewicz J, Baligand C, Monte J, den Harder C, Hooijmans MT, Nederveen AJ, Schlaeger S, Weidlich D, Karampinos DC, Stouge A, Vaeggemose M, D’Angelo M, Arrigoni F, Kan HE, Froeling M (2019): Multicenter evaluation of stability and reproducibility of quantitative MRI measures in healthy calf muscles. NMR Biomed:1–14.

Ocklenburg S, Anderson C, Gerding WM, Fraenz C, Schlüter C, Friedrich P, Raane M, Mädler B, Schlaffke L, Arning L, Epplen JT, Güntürkün O, Beste C, Genç E (2018) Myelin Water Fraction Imaging Reveals Hemispheric Asymmetries in Human White Matter That Are Associated with Genetic Variation in PLP1. Mol Neurobiol.

Rehmann R*, Schlaffke L*, Froeling M, Kley RA, Kühnle E, De Mareés M, Forsting J, Rohm M, Tegenthoff M, Schmidt-wilcke T, Vorgerd M (2018): Muscle diffusion tensor imaging in Glycogen storage disease V (McArdle disease). Eur Radiol 29:3224–3232.

Schlaffke, L.*, Rehmann, R.*, Froeling, M., Kley, R., Tegenthoff, M., Vorgerd, M., & Schmidt-Wilcke, T. (2017). Diffusion Tensor Imaging of the Human Calf : Variation of Inter- and Intramuscle-Specific Diffusion Parameters. J Magn Reson Imaging, 1–12. doi:10.1002/jmri.25650

Schlaffke L, Leemans A, Schweizer LM, Ocklenburg S, Schmidt-Wilcke T (2017). Learning Morse Code Alters Microstructural Properties in the Inferior Longitudinal Fasciculus: A DTI Study. Front Hum Neurosci 11: 383.

Schlaffke, L., Schweizer, L., Rüther, N. N., Luerding, R., Tegenthoff, M., Bellebaum, C., & Schmidt-Wilcke, T. (2016). Dynamic changes of resting state connectivity related to the acquisition of a lexico-semantic skill. NeuroImage. doi:10.1016/j.msea.2016.06.054

Schlaffke, L.*, Golisch, A.*, Haag, L. M.*, Lenz, M., Heba, S., Lissek, S., … Tegenthoff, M. (2015). The Brain’s Dress Code: How The Dress allows to decode the neuronal pathway of an optical illusion. Cortex, 73, 271–275.

Schlaffke L, Rüther NN, Heba S, Haag LM, Schultz T, Rosengarth K, Tegenthoff M, Bellebaum C, Schmidt-Wilcke T (2015b) From perceptual to lexico-semantic analysis-cortical plasticity enabling new levels of processing. Hum Brain Mapp

Schlaffke, L., Lissek, S., Lenz, M., Juckel, G., Schultz, T., Tegenthoff, M., Schmidt-Wilcke, T., Brüne, M. (2014): Shared and non-shared neural networks of cognitive and affective theory-of-mind: a neuroimaging study using cartoon picture stories. Human Brain Mapping, in press.

Ocklenburg S, Schlaffke L, Hugdahl K, Westerhausen R (2014) From structure to function in the lateralized brain: How structural properties of the arcuate and uncinate fasciculus are associated with dichotic listening performance. Neurosci Lett 580:32–36.

Lissek S, Vallana GS, Schlaffke L, Lenz M, Dinse HR, Tegenthoff M (2014) Opposing effects of dopamine antagonism in a motor sequence task - tiapride increases cortical excitability and impairs motor learning. Front Behav Neurosci 8

Gerber P*, Schlaffke L*, Heba S, Greenlee MW, Schultz T, Schmidt-Wilcke T (2014) Juggling revisited - A voxel-based morphometry study with expert jugglers. Neuroimage 95:320–325.

Schlaffke L, Lissek S, Lenz M, Brüne M, Juckel G, Hinrichs T, Platen P, Tegenthoff M, Schmidt-Wilcke T (2014) Sports and brain morphology - a voxel based morphometry study with endurance athletes and martial artists. Neuroscience 259:35–42.

Wiens V, Schlaffke L, Schmidt-Wilcke T, Schultz T (2014) Visualizing Uncertainty in HARDI Tractography Using Superquadric Streamtubes. EuroVis:1–6.

Schultz T, Schlaffke L, Schölkopf B, Schmidt-Wilcke T (2013) HiFiVE: A Hilbert Space Embedding of Fiber Variability Estimates for Uncertainty Modeling and Visualization. Comput Graph Forum 32:121–130.