Publications

Preprints

  • S. Veit, L.C. Paweletz, S.S.-R. Bohr, A.K. Menon, N.S. Hatzakis and T. Günther Pomorski (2022).
    A single vesicle fluorescence-bleaching assay for multi-parameter analysis of proteoliposomes by total internal reflection fluorescence microscopy.
    bioRxiv 2022.04.01.486744
    doi: 10.1101/2022.04.01.486744
     

Publikationen 2022

  • T. Dieudonné, S.A. Herrera, M.J. Laursen, M. Lejeune, C. Stock, K. Slimani, C. Jaxel, J.A. Lyons, C. Montigny, T. Günther Pomorski, P. Nissen and G. Lenoir (2022).
    Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders.
    eLife 2022;11: e75272
    doi: 10.7554/eLife.75272
    Abstract
     
  • P.P.M. Mathiassen and T.G. Pomorski (2022).
    A fluorescence-based assay for measuring phospholipid scramblase activity in giant unilamellar vesicles.
    Bio-protocol 12(4): e4366
    doi: 10.21769/BioProtoc.4366
    Abstract
     
  • S.A. Herrera, M. Grifell-Junyent, and T.G. Pomorski (2022).
    NBD-lipid uptake assay for mammalian cell lines.
    Bio-protocol 12(4): e4330
    doi: 10.21769/BioProtoc.4330
    Abstract
     
  • N.T. Johansen, M. Bonaccorsi, T. Bengtsen, A.H. Larsen, F.G. Tidemand, M.C. Pedersen, P. Huda, J. Berndtsson, T. Darwish, N.R. Yepuri, A. Martel, T.G. Pomorski, A. Bertarello, M. SP Sansom, M. Rapp, R. Crehuet, T. Schubeis, K. Lindorff-Larsen, G. Pintacuda, and L. Arleth (2022).
    Mg2+-dependent conformational equilibria in CorA and an integrated view on transport regulation.
    eLife 11: e71887
    doi: 10.7554/eLife.71887
    Abstract
     
  • C. Merritt, E.M. Chun, R.J. Fattah, L.M. Silva, Q.Q. Ma, M. Moayeri, D. Paliga, S. Neumann, R. Heumann, S.H. Leppla, T.H. Bugge (2022).
    Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry.
    Journal of Biological Chemistry 298(1): 101467
    doi: 10.1016/j.jbc.2021.101467
    Abstract
     
  • M. Grifell-Junyent, J.F. Baum, S. Välimets, A. Herrmann, C.C. Paulusma, R.L. López-Marqués and T. Günther Pomorski (2022).
    CDC50A is required for aminophospholipid transport and cell fusion in mouse C2C12 myoblasts.
    Journal of Cell Science 135(5): jcs258649
    doi: 10.1242/jcs.258649
    Abstract
     

Publikationen 2021

  • B. Ackermann, B. Dünschede, B. Pietzenuk, B.H. Justesen, U. Krämer, T. Günther Pomorski and D. Schünemann (2021).
    Chloroplast ribosomes interact with the insertase Alb3 in the thylakoid membrane.
    Frontiers in Plant Science 12: 781857
    doi: 10.3389/fpls.2021.781857
    Abstract
     
  • R.L. López-Marqués and T. Günther Pomorski (2021).
    Imaging of lipid uptake in Arabidopsis seedlings utilizing fluorescent lipids and confocal microscopy.
    Bioprotocol 11(22): e4228
    doi: 10.21769/BioProtoc.4228
    Abstract
     
  • L. D. Stanchev, J. Rizzo, R. Peschel, L.A. Pazurek, L. Bredegaard, S. Veit, S. Laerbusch, M.L. Rodrigues, R.L. López-Marqués and T. Günther Pomorski (2021).
    P-type ATPase Apt1 of the fungal pathogen Cryptococcus neoformans is a lipid flippase of broad substrate specificity.
    Journal of Fungi 7(10): 843
    doi: 10.3390/jof7100843
    Abstract
     
  • P.P.M. Mathiassen, A.K. Menon and T. Günther Pomorski (2021).
    Endoplasmic reticulum phospholipid scramblase activity revealed after protein reconstitution into giant unilamellar vesicles containing a photostable lipid reporter.
    Scientific Reports 11: 14364
    doi: 10.1038/s41598-021-93664-0
    Abstract
     
  • D. Marks, N. Heinen, L. Bachmann, S. Meermeyer, M. Werner, L. Gallego, P. Hemmerich, V. Bader, K.F. Winklhofer, E. Schröder, S.K. Knauer, and T. Müller (2021).
    Amyloid precursor protein elevates fusion of promyelocytic leukemia nuclear bodies in human hippocampal areas with high plaque load.
    Acta Neuropathologica Communications 9: 66
    doi: 10.1186/s40478-021-01174-x
    Abstract
     
  • K. Chen, Ö. Günay-Esiyok, M. Klingeberg, S. Marquardt, T. Günther Pomorski, and N. Gupta (2021).
    Aminoglycerophospholipid flipping and P4-ATPases in Toxoplasma.
    Journal of Biological Chemistry 296: 100315
    doi: 10.1016/j.jbc.2021.100315
    Abstract
     
  • L. Sistemich, L.D. Stanchev, M. Kutsch, A. Roux, T. Günther Pomorski, and C. Herrmann (2021).
    Structural requirements for membrane binding of human guanylatebinding protein 1.
    The FEBS Journal accepted
    doi: 10.1111/febs.15703
    Abstract
     

Publications 2020

  • F. Raudzus, H. Schöneborn, S. Neumann, E. Secret, A. Michel, J. Fresnais, O. Brylski, C. Ménager, J. M. Siaugue and R. Heumann (2020).
    Magnetic spatiotemporal control of SOS1 coupled nanoparticles for guided neurite growth in dopaminergic single cells.
    Scientific Reports 10: 22452
    doi: 10.1038/s41598-020-80253-w
    Abstract      Press Release
     
  • L.D. Stanchev, M. Marek, F. Xian, M. Klöhn, D. Silvestro, G. Dittmar, R.L. López-Marqués, and T. Günther Pomorski (2020).
    Functional significance of conserved cysteines in the extracellular loops of the ATP binding cassette transporter Pdr11p.
    Journal of Fungi 7(1): 2
    doi: 10.3390/jof7010002
    Abstract
     
  • C.D. Pereira, F. Martins, M. Santos, T. Müller, O.A.B. da Cruz e Silva, S. Rebelo (2020).
    Nuclear accumulation of LAP1: TRF2 complex during DNA damage response uncovers a novel role for LAP1.
    Cells 9(8): 1804.
    doi: 10.3390/cells9081804
    Abstract
     
  • R.L. López-Marqués, P. Gourdon, T. Günther Pomorski, and M. Palmgren (2020).
    The transport mechanism of P4 ATPase lipid flippases.
    Biochemical Journal 477(19): 3769–3790
    doi: 10.1042/BCJ20200249
    Abstract
     
  • M. Bongaerts, K. Aizel, E. Secret, A. Jan, T. Nahar, F. Raudzus, S. Neumann, N. Telling, R. Heumann, J.M. Siaugue, C. Ménager, J. Fresnais, C. Villard, A. El Haj, J. Piehler, M.A. Gates, and M. Coppey (2020).
    Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces.
    International Journal of Molecular Sciences 21(18): 6560
    doi: 10.3390/ijms21186560
    Abstract
     
  • M.M. Frøsig, S.R. Costa, J. Liesche, J.T. Østerberg, S. Hanisch, S. Nintemann, H. Sørensen, M. Palmgren, T. Günther Pomorski, and R.L. López-Marqués (2020).
    Pseudohyphal growth in Saccharomyces cerevisiae involves protein kinase-regulated lipid flippases.
    Journal of Cell Science 133: jcs235994
    doi: 10.1242/jcs.235994
    Abstract
     
  • L.R. Knoke, S. Abad Herrera, K. Götz, B.H. Justesen, T. Günther Pomorski, C. Fritz, S. Schäkermann, J. E. Bandow, and M. Aktas (2020).
    Agrobacterium tumefaciens small lipoprotein Atu8019 is involved in selective outer membrane vesicle (OMV) docking to bacterial cells.
    Frontiers in Microbiology 11: 1228
    doi: 10.3389/fmicb.2020.01228
    Abstract
     
  • S.S.-R. Bohr, C. Thorlaksen, R.M. Kühnel, Thomas Günther-Pomorski, and N.S. Hatzakis (2020).
    Label-free fluorescence quantification of hydrolytic enzyme activity on native substrates reveals how lipase function depends on membrane curvatures.
    Langmuir
    doi: 10.1021/acs.langmuir.0c00787
    Abstract
     
  • V. Hartmann, D. Harris, T. Bobrowski, A. Ruff, A. Frank, T. Günther Pomorski, M. Rögner, W. Schuhmann, N. Adir, and M.M. Nowaczyk (2020).
    Improved quantum efficiency in an engineered light harvesting/photosystem II super-complex for high current density biophotoanodes.
    Journal of Materials Chemistry A
    doi: 10.1039/D0TA03444D
    Abstract
     
  • T. Paulraj, S. Wennmalm, D.C.F. Wieland, A.V. Riazanova, A. Dėdinaitė, T. Günther Pomorski, M. Cárdenas, and A.J. Svagan (2020).
    Primary cell wall inspired micro containers as a step towards a synthetic plant cell.
    Nature Communications 11: 958
    doi: 10.1038/s41467-020-14718-x
    Abstract
     

Publications 2019

  • T. Günther Pomorski and A. Herrmann (2019).
    Lipid flip-flop.
    Encyclopedia of Biophysics
    doi: 10.1007/978-3-642-35943-9_551-1
     
  • X. Liu, T. Günther Pomorski, and J. Liesche (2019).
    Non-invasive quantification of cell wall porosity by fluorescence quenching microscopy.
    Bio-Protocol 9(16)
    doi: 10.21769/BioProtoc.3344
    Abstract
     
  • J. Rizzo, L.D. Stanchev, V.K.A. da Silva, L. Nimrichter, T. Günther Pomorski, and M.L. Rodrigues (2019).
    Role of lipid transporters in fungal physiology and pathogenicity.
    Computational and Structural Biotechnology Journal
    doi: 10.1016/j.csbj.2019.09.001
    Abstract
     
  • H. Schöneborn, F. Raudzus, E. Secret, N. Otten, A. Michel, J. Fresnais, C. Ménager, J.-M. Siaugue, H. Zaehres, I.D. Dietzel and R. Heumann (2019).
    Novel tools towards magnetic guidance of neurite growth: (I) Guidance of magnetic nanoparticles into neurite extensions of induced human neurons and in vitro functionalization with RAS regulating proteins.
    Journal of Functional Biomaterials 10(3): 32
    doi: 10.3390/jfb10030032
    Abstract
     
  • S. Maric, T.K Lind, M.R. Raida, E. Bengtsson, G.N. Fredrikson, S. Rogers, M. Moulin, M. Haertlein, V.T. Forsyth, M.R. Wenk, T. Günther Pomorski, T. Arnebrant, R. Lund and M. Cárdenas (2019).
    Time-resolved small-angle neutron scattering as a probe for the dynamics of lipid exchange between human lipoproteins and naturally derived membranes.
    Scientific Reports 9: 7591
    doi: 10.1038/s41598-019-43713-6
    Abstract
     
  • S.M. Sundaram, D. Safina, A. Ehrkamp, A. Faissner, R. Heumann and I.D. Dietzel (2019).
    Differential expression patterns of sodium potassium ATPase alpha and beta subunit isoforms in mouse brain during postnatal development.
    Neurochemistry International 128: 163–174
    doi: 10.1016/j.neuint.2019.04.009
    Abstract
     
  • R.M. Kühnel, M.G. Junyent, I.L. Jørgensen, G.C. Kemmer, J. Schiller, M.B. Palmgren, B.H. Justesen and T. Günther Pomorski (2019).
    Short-chain lipid-conjugated pH-sensors for imaging of transporter activities in reconstituted systems and living cells.
    Analyst 144: 3030
    doi: 10.1039/C8AN02161A
    Abstract
     
  • L. Theorin, K. Faxen, D.M. Sørensen, R. Migotti, G. Dittmar, J. Schiller, D.L. Daleke, M. Palmgren, R.L. López-Marqués, and T. Günther-Pomorski (2019).
    The lipid head group is the key element for substrate recognition by the P4 ATPase ALA2, a phosphatidylserine flippase.
    Biochemical Journal 476(5): 783–794
    doi: 10.1042/BCJ20180891
    Abstract
     
  • D.M. Sørensen, H.W. Holen, J.T. Pedersen, H.J. Martens, D. Silvestro, L.D. Stanchev, S.R. Costa, T. Günther-Pomorski, R.L. López-Marqués, and M. Palmgren (2019).
    The P5A ATPase Spf1p is stimulated by phosphatidylinositol 4-phosphate and influences cellular sterol homeostasis.
    Molecular Biology of the Cell 30(9): 1069–1084
    doi: 10.1091/mbc.E18-06-0365
    Abstract
     
  • X. Liu, J. Li, H. Zhao, B. Liu, T. Günther-Pomorski, S. Chen, and J. Liesche (2019).
    Novel tool to quantify cell wall porosity relates wall structure to cell growth and drug uptake.
    The Journal of Cell Biology 218(4): 1407–1420
    doi: 10.1083/jcb.201810121
    Abstract
     

Publications 2018

  • H. Schöneborn, F. Raudzus, M. Coppey, S. Neumann, and R. Heumann (2018).
    Perspectives of RAS and RHEB GTPase signaling pathways in regenerating brain neurons.
    International Journal of Molecular Sciences 19(12): 4052
    doi: 10.3390/ijms19124052
    Abstract
     
  • D. Paliga, F. Raudzus, S.H. Leppla, R. Heumann, and S. Neumann (2018).
    Lethal factor domain-mediated delivery of Nurr1 transcription factor enhances tyrosine hydroxylase activity and protects from neurotoxin-induced degeneration of dopaminergic cells.
    Molecular Neurobiology 56(5): 3393–3403
    doi: 10.1007/s12035-018-1311-6
    Abstract      Press Release
     
  • L.M. Solanko, D.P. Sullivan, Y.Y. Sere, M. Szomek, A. Lunding, K.A. Solanko, A. Pizovic, L.D. Stanchev, T. Günther-Pomorski, A.K. Menon, and D. Wüstner (2018).
    Ergosterol is mainly located in the cytoplasmic leaflet of the yeast plasma membrane.
    Traffic 19: 198–214.
    doi: 10.1111/tra.12545
    Abstract
     
  • T.T. Tung, T.T. Dao, M.G. Junyent, M. Palmgren, T. Günther-Pomorski, A.T. Fuglsang, S.B. Christensen, and J. Nielsen (2018).
    LEGO-inspired drug design: unveiling of the novel class of benzo[d]thiazole containing a 3,4-dihydroxyphenyl moiety as plasma membrane H+-ATPase inhibitors.
    ChemMedChem 13(1): 37–47.
    doi: 10.1002/cmdc.201700635
    Abstract
     

Publications 2017

  • M.S. Jensen, S.R. Costa, A.S. Duelli, P.A. Andersen, L.R. Poulsen, L.D. Stanchev, P. Gourdon, M. Palmgren, T. Günther Pomorski, and R.L. López-Marqués (2017).
    Phospholipid flipping involves a central cavity in P4 ATPases.
    Scientific Reports 7: 17621.
    doi: 10.1038/s41598-017-17742-y
    Abstract
     
  • K.R. Laub, M. Marek, L.D. Stanchev, S. Abad Herrera, T. Kanashova, A. Bourmaud, G. Dittmar, and T. Günther Pomorski (2017).
    Purification and characterisation of the yeast plasma membrane ATP binding cassette transporter Pdr11p.
    PLoS ONE 12(9): e0184236.
    doi: 10.1371/journal.pone.0184236
    Abstract
     
  • I.L. Jørgensen, G.C. Kemmer, and T. Günther Pomorski (2017).
    Membrane protein reconstitution into giant unilamellar vesicles: a review on current techniques.
    European Biophysics Journal 46(2): 103–119.
    doi: 10.1007/s00249-016-1155-9
    Abstract
     

Publications 2016

  • S. Veshaguri, S.M. Christensen, G.C. Kemmer, G. Ghale, M.P. Møller, C. Lohr, A.L. Christensen, B.H. Justesen, I.L. Jørgensen, J. Schiller, N.S. Hatzakis, M. Grabe, T. Günther Pomorski, and D. Stamou (2016).
    Direct observation of proton pumping by a eukaryotic P-type ATPase.
    Science 351(6280): 1469–1473.
    doi: 10.1126/science.aad6429
    Abstract
     
  • T. Günther-Pomorski and A.K. Menon (2016).
    Lipid somersaults: Uncovering the mechanisms of protein-mediated lipid flipping.
    Progress in Lipd Research 64: 69–84.
    doi: 10.1016/j.plipres.2016.08.003
    Abstract
     
  • M.S. Jensen, S.R. Costa, L. Theorin, J.P. Christensen, T. Günther-Pomorski, and R.L. López-Marqués (2016).
    Application of image cytometry to characterize heterologous lipid flippases in yeast.
    Cytometry Part A 89(7): 673–680.
    doi: 10.1002/cyto.a.22886
    Abstract
     
  • S.R. Costa, M. Marek, K.B. Axelsen, L. Theorin, T. Günther-Pomorski, and R.L. López-Marqués (2016).
    Role of post-translational modifications at the β-subunit ectodomain in complex association with a promiscuous plant P4-ATPase.
    Biochemical Journal 473(11): 1605–1615.
    doi: 10.1042/BCJ20160207
    Abstract
     
  • V. Jagalski, R. Barker, D. Topgaard, T. Günther-Pomorski, B.R. Hamberger, and M. Cárdenas (2016).
    Biophysical study of resin acid effects on phospholipid membrane structure and properties.
    Biochimica et Biophysica Acta – Biomembranes 1858(11): 2827–2838.
    doi: 10.1016/j.bbamem.2016.08.008
    Abstract
     
  • M.S. Jensen, S. Costa, T. Günther-Pomorski, and R.L. López-Marqués (2016).
    Cell-based lipid flippase assay employing fluorescent lipid derivatives.
    Methods in Molecular Biology 1377: 371–382.
    doi: 10.1007/978-1-4939-3179-8_33
    Abstract
     
  • M. Marek and T. Günther Pomorski (2016).
    Assay of flippase activity in proteoliposomes using fluorescent lipid derivatives.
    Methods in Molecular Biology 1377: 181–191.
    doi: 10.1007/978-1-4939-3179-8_18
    Abstract
     
  • A.G. Wielandt, M.G. Palmgren, A.T. Fuglsang, T. Günther-Pomorski, and B.H. Justesen (2016).
    Measuring H+ pumping and membrane potential formation in sealed membrane vesicle systems.
    Methods in Molecular Biology 1377: 171–180.
    doi: 10.1007/978-1-4939-3179-8_17
    Abstract
     

Publications 2015

  • V. Jagalski, R. Barker, M.B. Thygesen, K. Gotfryd, M. Kruger, L. Shi, S. Maric, N. Bovet, M. Moulin, M. Haertlein, T. Günther Pomorski, C.J. Loland, and M. Cárdenas (2015).
    Grafted biomembranes containing membrane proteins – The case for the leucine transporter.
    Soft Matter 11: 7707–7711.
    doi: 10.1039/C5SM01490E
    Abstract
     
  • I. Ziomkiewicz, J. Sporring, T. Günther Pomorski, and A. Schulz (2015).
    Novel approach to measure the size of plasma-membrane nanodomains in single molecule localization microscopy.
    Cytometry Part A 87(9): 868–877.
    doi: 10.1002/cyto.a.22708
    Abstract
     
  • G.C. Kemmer, S.A. Bogh, M. Urban, M.G. Palmgren, T. Vosch, J. Schillerd, and T. Günther Pomorski (2015).
    Lipid-conjugated fluorescent pH sensors for monitoring pH changes in reconstituted membrane systems.
    Analyst 140: 6313–6320.
    doi: 10.1039/C5AN01180AE
    Abstract
     
  • T. Holemans, D.M. Sørensen, S. van Veen, S. Martin, D. Hermans, G.C. Kemmer, C. van den Haute, V. Baekelandt, T. Günther Pomorski, P. Agostinis, F. Wuytack, M. Palmgren, J. Eggermont, and P. Vangheluwe (2015).
    A lipid switch unlocks Parkinson’s disease-associated ATP13A2.
    Proceedings of the National Academy of Sciences (USA) 112(29): 9040–9045.
    doi: 10.1073/pnas.1508220112
    Abstract
     
  • R.L. López-Marqués, L.R. Poulsen, A. Bailly, M. Geisler, T. Günther Pomorski, and M.G. Palmgren (2015).
    Structure and mechanism of ATP-dependent phospholipid transporters.
    Biochimica et Biophysica Acta 1850(3): 461–475.
    doi: 10.1016/j.bbagen.2014.04.008
    Abstract
     
  • S. Maric, M.B. Thygesen, J. Schiller, M. Marek, M. Moulin, M. Haertlein, T.V. Forsyth, M. Bogdanov, W. Dowhan, L. Arleth, T. Günther Pomorski (2015).
    Biosynthetic preparation of selectively deuterated phosphatidylcholine in genetically modified Escherichia coli.
    Applied Microbiology and Biotechnology 99(1): 241–254.
    doi: 10.1007/s00253-014-6082-z
    Abstract
     

Publications 2014

  • B.J. Justesen and T. Günther Pomorski (2014).
    Chromatographic and electrophoretic methods for nanodisc purification and analysis.
    Reviews of Analytical Chemistry 33(3): 165–172.
    doi: 10.1515/revac-2014-0014
    Abstract
     
  • T. Günther Pomorski, T. Nylander, and M. Cárdenas (2014).
    Model cell membranes: Discerning lipid and protein contributions in shaping the cell.
    Advances in Colloid and Interface Science 205: 207–220.
    doi: 10.1016/j.cis.2013.10.028
    Abstract
     
  • S. Maric, N. Skar-Gislinge, S. Midtgaard, M.B. Thygesen, J. Schiller, H. Frielinghaus, M. Moulin, M. Haertlein, V.T. Forsyth, T. Günther Pomorski, and L. Arleth (2014).
    Stealth carriers for low-resolution structure determination of membrane proteins in solution.
    Acta Crystallographica Section D – Structural Biology 70: 317–328.
    doi: 10.1107/S1399004713027466
    Abstract
     

Publications 2013

Publications 2012

Publications 2011

Publications 2010

Publications 2009

Publications 2008

Publications 2007

Bücher

Publication of the Year