RUB » Biochemistry I - Receptor Biochemistry


Celebration 30 Years of Biochemistry


Praktikumssaal BiochemieTo celebrate the 30th anniversary of our biochemistry studies course we invite all graduates to a celebration on 01.10.2022. Please register via e-mail. The programme and the registration form an be found on the website of the faculty.



Sebastian ObstWe congratulate Sebastian Obst on achieving his doctorate degree.



NMDA receptor peptidesUp to 20% of the population carry anti­bodies against glutamate receptors of the NMDA type independent of any disease, with pre­valence increasing with age. In colla­bo­ration with the Clinical Neuroscience Group of Hannelore Ehrenreich at the Max Planck Institute for Experimental Medicine in Göttingen, we have now shown a similar prevalence of antibodies against NMDA receptors in other mammals. Dogs, cats, rats and mice also displayed the age de­penden­cy found in most humans, whereas baboons and rhesus macaques in captivity did not. Based on this result and the observation that human migrants also show a weaker age dependency, we hypothesise that chronic stress triggers the antibody production.

When we immunised mice against NMDA receptors, they produced large amounts of antibodies. When the animals had a disrupted blood-brain barrier, they showed psychosis-like symptoms like the ones known to be caused by drug-induced NMDA receptor block. However, none of the animals had any signs of brain inflammation (encephalitis). This indicates that some of the symptoms observed in encephalitis patients carrying antibodies against NMDA receptors may indeed be caused by the antibodies, whereas the encephalitis itself has another cause.

Abstract. The complete article is openly accessible.

Previous news

Head of Department

Prof. Dr. Michael Hollmann


Lehrstuhl für Biochemie I - Rezeptorbiochemie
NC 6/171

Ruhr-Universität Bochum
44780 Bochum

Tel.: +49 234 32-28225
Fax: +49 234 32-14244

How to find us

Central website of the Ruhr University

Sequencing Service

DNA sequencing service for all faculties of the Ruhr University