RUB » Biochemistry I - Receptor Biochemistry » Research » Autoantibodies against Glutamate Receptors

Autoantibodies against Glutamate Receptors

Delta-ProjektSome types of brain inflammation occurring in humans are autoimmune diseases associated with antibodies against glutamate receptors. Recently the first case of such an autoimmune brain inflammation in an animal was reported, namely in the famous polar bear Knut. We are working on the characterisation of autoantibodies occurring in autoimmune brain inflammations as well as on the question whether autoantibodies against glutamate receptors play a role in other diseases of the nervous system as well.


Project-Related Publications

  • S. Arinrad, J.B.H. Wilke, A. Seelbach, J. Doeren, M. Hindermann, U.J. Butt, A.A. Steixner-Kumar, L. Spieth, A. Ronnenberg, H. Pan, S.A. Berghoff, M. Hollmann, F. Lühder, K.-A. Nave, K. Bechter, and H. Ehrenreich (2022).
    NMDAR1 autoantibodies amplify behavioral phenotypes of genetic white matter inflammation: A mild encephalitis model with neuropsychiatric relevance.
    Molecular Psychiatry 27: 4974-4983.
    doi: 10.1038/s41380-021-01392-8
    Abstract
     
  • J.B.H. Wilke, M. Hindermann, S. Berghoff, S. Zihsler, S. Arinrad, A. Ronnenberg, N. Barnkothe, A.A. Steixner-Kumar, S. Röglin, W. Stöcker, M. Hollmann, K.-A. Nave, F. Lühder and H. Ehrenreich (2021).
    Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis.
    Molecular Psychiatry 26: 7746-7759.
    doi: 10.1038/s41380-021-01238-3
    Abstract
     
  • H. Pan, A.A. Steixner-Kumar, A. Seelbach, N. Deutsch, A. Ronnenberg, D. Tapken, N. von Ahsen, M. Mitjans, H. Worthmann, R. Trippe, C. Klein-Schmidt, N. Schopf, K. Rentzsch, M. Begemann, J. Wienands, W. Stöcker, K. Weissenborn, M. Hollmann, K.-A. Nave, F. Lühder, and H. Ehrenreich (2021).
    Multiple inducers and novel roles of autoantibodies against the obligatory NMDAR subunit NR1: a translational study from chronic life stress to brain injury.
    Molecular Psychiatry 26: 2471-2482
    doi: 10.1038/s41380-020-0672-1
    Abstract
     
  • H. Ehrenreich, H. Pan, and M. Hollmann (2019).
    Active immunization, autoimmunity and encephalitis: The missing links.
    Letter to Science Translational Medicine. 11(500)
    https://stm.sciencemag.org/content/11/500/eaaw0044/tab-e-letters
     
  • J.B.H. Wilke, H. Ehrenreich, and M. Hollmann (2019).
    Autoantibodies against NMDA receptors – Janus-faced molecules?
    Neuroforum 25(2).
    doi: 10.1515/nf-2018-0025
    Abstract
     
  • H. Pan, B. Oliveira, G. Saher, E. Dere, D. Tapken, M. Mitjans, J. Seidel, J, Wesolowski, D. Wakhloo, C. Klein-Schmidt, A. Ronnenberg, K. Schwabe, R. Trippe, K. Mätz-Rensing, S. Berghoff, Y. Al-Krinawe, H. Martens, M. Begemann, W. Stöcker, F.-J. Kaup, R. Mischke, S. Boretius, K.-A. Nave, J.K. Krauss, M. Hollmann, F. Lühder, and H. Ehrenreich (2019).
    Uncoupling the widespread occurrence of anti-NMDAR1 autoantibodies from neuropsychiatric disease in a novel autoimmune model.
    Molecular Psychiatry 24: 1489-1501.
    doi: 10.1038/s41380-017-0011-3
    Abstract
     
  • E. Castillo-Gómez, B. Oliveira, D. Tapken, S. Bertrand, C. Klein-Schmidt, H. Pan, P. Zafeiriou, J. Steiner, B. Jurek, R. Trippe, H. Prüss, W.-H. Zimmermann, D. Bertrand, H. Ehrenreich, and M. Hollmann (2017).
    All naturally occurring autoantibodies against the NMDA receptor subunit NR1 have pathogenic potential irrespective of epitope and immunoglobulin class.
    Molecular Psychiatry 22: 1776-1784.
    doi: 10.1038/mp.2016.125
    Abstract      Press Release
     
  • J. Trippe, K. Steinke, A. Orth, P.M. Faustmann, M. Hollmann, and C.G. Haase (2014).
    Autoantibodies to glutamate receptor antigens in multiple sclerosis and Rasmussen's encephalitis.
    Neuroimmunomodulation 21: 189-194.
    doi: 10.1159/0003565197
    Abstract
     

Project-Related Doctoral Theses

  • Jürgen Trippe
    Investigations on the autoimmunity against ionotropic glutamate receptors in multiple sclerosis and Rasmussen's encephalitis patients
    2014
    Download thesis as pdf (4,9 MB)
     

Project-Related Master Theses

  • Katja Steinke
    Analysis of autoimmunity against glutamate receptors in multiple sclerosis patients
    03.03.2008 to 02.09.2008
     
  • Angela Orth
    Analysis of autoimmunity against ionotropic glutamate receptors in multiple sclerosis and Rasmussen's encephalitis patients
    01.03.2007 to 31.08.2007
     

Scientists Involved

Faezeh SadrabadiFaezeh Sadrabadi
Room NC 6/131
Tel. +49 234 32-27496
E-mail


My Tien LuuMy Tien Luu
Room NC 6/167
Tel. +49 234 32-28240
E-mail


Rebecca BakeRebecca Bake
Room NC 6/167
Tel. +49 234 32-28240
E-mail


Ralf TrippeDr. Ralf Trippe
Room NC 6/167
Tel. +49 234 32-28240
E-mail


Daniel TapkenDr. Daniel Tapken
Room NC 6/132
Tel. +49 234 32-24233
Fax +49 234 32-14034
E-mail


Justus WilkeJustus Wilke
At the department until 2018
E-mail


Jürgen TrippeJürgen Trippe
At the department until 2014


Angela OrthAngela Orth
At the department until 2013
Currently University of Düsseldorf
E-mail


Katja SteinkeKatja Steinke
At the department until 2012
E-mail