Functional Characterisation of Glutamate Receptors of the Delta Subfamily
The delta receptors are two proteins that closely resemble glutamate receptors. Therefore, they have been included in the family of glutamate receptors as a separate subfamily. Yet they do not show any ion channel function as glutamate receptors typically do. We are working on the question of why delta receptors lack this functionality and what function they have instead.
Project-Related Publications
- M. Masternak, A. Koch, S. Laulumaa, D. Tapken, M. Hollmann, F.S. Jørgensen, and J.S. Kastrup (2023).
Differences between the GluD1 and GluD2 receptors revealed by GluD1 X-ray crystallography, binding studies and molecular dynamics.
FEBS Journal 290(15): 3781-3801.
doi: 10.1111/febs.16631
Abstract
- D. Tapken, T.B. Steffensen, R. Leth, L.B. Kristensen, A. Gerbola, M. Gajhede, F.S. Jørgensen, L. Olsen, and J.S. Kastrup (2017).
The low binding affinity of D-serine at the ionotropic glutamate receptor GluD2 can be attributed to the hinge region.
Scientific Reports 7: 46145.
doi: 10.1038/srep46145
Abstract
- A. Orth, D. Tapken, and M. Hollmann (2013).
The delta subfamily of glutamate receptors: characterization of receptor chimeras and mutants.
European Journal of Neuroscience 37(10): 1620-1630.
doi: 10.1111/ejn.12193
Abstract
- S.M. Schmid, S. Kott, C. Sager, T. Huelsken, and M. Hollmann (2009).
The glutamate receptor subunit delta2 is capable of gating its intrinsic ion channel as revealed by ligand binding domain transplantation.
Proceedings of the National Academy of Sciences (USA) 106(25): 10320-10325.
doi: 10.1073/pnas.0900329106
Abstract Press Release
- S.M. Schmid and M. Hollmann (2008).
To gate or not to gate: Are the delta subunits in the glutamate receptor family functional ion channels?
Molecular Neurobiology 37(2-3): 126-141.
doi: 10.1007/s12035-008-8025-0
Abstract
Project-Related Doctoral Theses
- Angela Orth
The delta subfamily of glutamate receptors: Identification of interacting proteins and characterisation of receptor chimaeras and mutants
October 2007 to November 2011
Download thesis as pdf (5,4 MB)
- Sabine Schmid
Investigation of the delta subfamily of glutamate receptors by domain transplantation
October 2003 to April 2008
Download thesis as pdf (8,2 MB)
Project-Related Master Theses
- Gordon Hicking
Investigations on the glutamate receptor delta1, especially with regard to its possible function in hearing
to 13.09.2010
- Sabine Schmid
Investigations of domains potentially relevant to the function of the glutamate receptor delta 2
17.01.2003 tos 08.2003
Project-Related Bachelor Theses
- Jan Trapp
Characterisation of a disease-associated mutation in the glutamate receptor subunit GluD2
27.09.2019
Supervisor: Dr. Daniel Tapken
- Solveig Herrmann
Saturating mutagenesis at the lurcher position of the AMPA receptor GluR1 and the orphan receptor delta2
30.09.2005
Supervisor: Sabine Schmid
Tobias Strasdeit
Angela Orth
Sabine Schmid