Assembly and Intracellular Trafficking of Glutamate Receptors
Glutamate receptors are large membrane protein complexes consisting of four subunits. To form a functional receptor, the subunits have to find each other within the cell, assemble, and be transported to the membrane. Using confocal microscopy and biochemical methods, we study where the assembly takes place, which factors govern it, and how the complexes get to the membrane.
Project-Related Publications
- Z.-L. Ma-Högemeier, C. Körber, M. Werner, D. Racine, E. Muth-Köhne, D. Tapken, and M. Hollmann (2010).
Oligomerization in the endoplasmic reticulum and intracellular trafficking of kainate receptors are subunit- but not editing-dependent.
Journal of Neurochemistry 113(6): 1403-1415.
doi: 10.1111/j.1471-4159.2009.06559.x
Abstract
- Z.-L. Ma, M. Werner, C. Körber, I. Joshi, M. Hamad, P. Wahle, and M. Hollmann (2007).
Quantitative analysis of co-transfection efficiencies in studies of ionotropic glutamate receptor complexes.
Journal of Neuroscience Research 85(1): 99-115.
doi: 10.1002/jnr.21096
Abstract
Project-Related Doctoral Theses
- Zhan-Lu Ma
Assembly and intracellular trafficking of glutamate receptors
Oktober 2002 bis Oktober 2007
Download thesis as pdf (5.1 MB)
Zhan-Lu Ma-Högemeier, Ph.D.