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Research Projects

Monoamiergic GPCR Signals
Visualization and control of serotonin and dopamine receptor function in cortical neuronal processing in mice.

p1     Prof. Dr. Stefan Herlitze
Visualization and temporal resolution of 5-HT receptor subtype participation in subcellular receptor domains of cortical neuron processing

p2     Prof. Dr. Andreas Reiner
Engineering of photoswitchable 5-HT and DA receptors for probing of 5-HT-1/2/D2 receptor function and heteromerization


Neurodegeneration
Noradrenaline and dopamine receptor function in Parkinson's and Alzheimer’s disease in mouse models.

p3    Prof. Dr. Konstanze Winklehofer
Investigating dopamine receptor signaling networks and their role in neurodegeneration

p4    Prof. Dr. Denise Manahan-Vaughan
Investigation of the role of catecholaminergic neurons in the pathogenesis of neurodegeneration


Dystonia
Noradrenaline and dopamine receptor function in episodic ataxia type 2 and dystonia type 25 mouse models

p5    Prof. Dr. Melanie D. Mark
Investigation of the spatiotemporal noradrenaline dynamics during a stress-induced dystonic episode in an episodic ataxia type 2 (EA2) mouse cerebellum

p6    Prof. Dr. Huu-Phuc Nguyen
Investigating the interaction of D1R, D2R, A2AR, NMDAR and mGluR5 signaling pathways in Gnal-knockout rats


Mania & Depression
Sertonin and dopamine receptor function in major depression and mania in mouse models.

p7    Dr. Katharina Spoida
Investigation of the role of 5-HT receptor signals in the LHb regulating depressive-like behavior in mice

p8    Jun. Prof. Dr.  Nadja Freund
Investigating the role of prefrontal dopamine D1 receptors in depressive- and mania-like behavior


Blindness & Vision
Sertonin and dopamine receptor function in retina and visual cortex of blind mice.

p9     Dr. Ida Siveke
Optogenetic targeting of dopamine signaling in the mouse retina and decreasing the burden of vision impairments following retina degeneration

p10   PD Dr. Dirk Jancke
Enhancing visual cortical plasticity and restoration of retinal function by means of optogenetic control of 5-HT receptor si