Publikationen

2017

Ince S., Kutsch M., Shydlovskyi S., and Herrmann C. (2017). The human guanylate-binding proteins hGBP-1 and hGBP-5 cycle between monomers and dimers only. FEBS J., doi: 10.1111/febs.14126.

Shydlovskyi, S., Zienert, A. Y., Ince, S., Dovengerds, C., Hohendahl, A., Dargazanli, J. M., Blum, A., Günther, S. D., Kladt, N., Stürzl, M., Schauss, A., Kutsch, M., Roux, A., Praefcke, G. J. K., and Herrmann, C. (2017). Nucleotide-dependent farnesyl switch orchestrates polymerization and membrane binding of human guanylate-binding protein 1. Proc. Natl. Acad. Sci., doi: 10.1073/pnas.1620959114.

S.M. Gopal, F. Klumpers, C. Herrmann, L.V. Schäfer, "Solvent effects on ligand binding to a serine protease". Phys. Chem. Chem. Phys. (2017) Jan 24. doi: 10.1039/ c6cp07899k.

A. Koturenkiene, C. Makbul, C. Herrmann, , D. Constantinescu-Aruxandei, "Kinetic characterization of apoptotic Ras signalling through Nore1-MST1 complex formation". Biol. Chem. (2017) Jan 28. doi: 10.1515/hsz-2016-0291.

2016

M. Kutsch, P. Hortmann, C. Herrmann, Weibels S, Weingärtner H. "Dissecting ion-specific from electrostatic salt effects on amyloid fibrillation: A case study of insulin". Biointerphases 11, 019008 (2016)

M. Schöpel, C. Herrmann, J. Scherkenbeck, R. Stoll, "The Bisphenol A analogue Bisphenol S binds to K-Ras4B--implications for 'BPA-free' plastics". FEBS Lett. 590, 369-75. (2016)

P.S. Athanasopoulos, W. Jacob, S. Neumann, M. Kutsch, D. Wolters, E.K. Tan, Z. Bichler, C. Herrmann, R. Heumann, "Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2." Biol Chem. 397, 541-554 (2016)

N. Britzen-Laurent, C. Herrmann, E. Naschberger, R.S. Croner, M. Stürzl, "Pathophysiological role of guanylate-binding proteins in gastrointestinal diseases". World J Gastroenterol. 22, 6434-6443 (2016)

M. Senske, D. Constantinescu-Aruxandei, M. Havenith, C. Herrmann, H. Weingärtner, S. Ebbinghaus, "The temperature dependence of the Hofmeister series: thermodynamic fingerprints of cosolute-protein interactions". Phys. Chem. Chem. Phys. 18, 29698-29708 (2016)

2014

S. Hartwig, C. Dovengerds, C. Herrmann, B.T. Hovemann, "Drosophila Ebony: a novel type of nonribosomal peptide synthetase related enzyme with unusually fast peptide bond formation kinetics". FEBS J. 281, 5147-5158 (2014)

K. E. Overkamp, R. Gasper, K. Kock, C. Herrmann, E. Hofmann, N. Frankenberg-Dinkel, "Insights into the Biosynthesis and Assembly of Cryptophycean Phycobiliproteins". J Biol Chem. 289, 26691-26707 (2014)

F. Klumpers, U. Götz, T. Kurtz, C. Herrmann, T.M.A. Gronewold, "Conformational changes at protein-protein interaction followed online with an SAW biosensor". Sensors and Actuators B 203, 904-908 (2014)

T. Vöpel, C. S. Hengstenberg, T. O. Peulen, Y. Ajaj, C. A. Seidel, C. Herrmann, J. P. Klare, "Triphosphate Induced Dimerization of Human Guanylate Binding Protein 1 Involves Association of the C-Terminal Helices: A Joint Double Electron-Electron Resonance and FRET Study". Biochemistry 53, 4590-4600 (2014)

M. Senske, L. Törk, B. Born, M. Havenith, C. Herrmann, S. Ebbinghaus, "Protein stabilization by macromolecular crowding through enthalpy rather than entropy". J. Am. Chem. Soc. 136, 9036-9041 (2014)

I. C. Rosnizeck, D. Filchtinski, R. P. Lopes, B. Kieninger, C. Herrmann, H. R. Kalbitzer, M. Spoerner, "Elucidating the Mode of Action of a Typical Ras State 1(T) Inhibitor". Biochemistry 53, 3867-3878 (2014)

M. S. Taha, K. Nouri, L. G. Milroy, J. M. Moll, C. Herrmann, L. Brunsveld, R. P. Piekorz, M. R. Ahmadian, "Subcellular fractionation and localization studies reveal a direct interaction of the fragile X mental retardation protein (FMRP) with nucleolin". PLoS One 9, e91465 (2014)

S. Baumgart, F. Jansen, W. Bintig, B. Kalbe, C. Herrmann, F. Klumpers, S. D. Köster, P. Scholz, S. Rasche, R. Dooley, N. Metzler-Nolte, M. Spehr, H. Hatt, E. M. Neuhaus, "Scaffolding by MUPP1 regulates odorant-mediated signaling in olfactory sensory neurons".
J. Cell Sci. 127, 2518-2527 (2014)

N. Ostler, N. Britzen-Laurent, A. Liebl, E. Naschberger, G. Lochnit, M. Ostler, F. Forster, P. Kunzelmann, S. Ince, V. Supper, G. J. K. Praefcke, D. W. Schubert, H. Stockinger, C. Herrmann, M. Stürzl, "IFN-γ-induced Guanylate Binding Protein-1 is a novel Actin Cytoskeleton Remodeling Factor". Mol. Cell. Biol. 34, 196-209 (2014)

2013

Ehrkamp A, Herrmann C, Stoll R, Heumann R. "Ras and rheb signaling in survival and cell death". Cancers 5, 639-661 (2013)

M. Schöpel, K. F. Jockers, P.M. Düppe, J. Autzen, V. N. Potheraveedu, S. Ince, K.T. Yip, R. Heumann, C. Herrmann, J. Scherkenbeck, R. Stoll "Bisphenol A Binds to Ras Proteins and Competes with Guanine Nucleotide Exchange: Implications for GTPase-Selective Antagonists". J. Med. Chem. 56, 9664-9672 (2013)

M. Ritzefeld, V. Walhorn, C. Kleineberg, A. Bieker, K. Kock, C. Herrmann, D. Anselmetti, N. Sewald, "Cooperative Binding of PhoBDBD to Its Cognate DNA Sequence-A Combined Application of Single-Molecule and Ensemble Methods". Biochemistry 52, 8177-8186 (2013)

C. Makbul, D. C. Aruxandei, E. Hofmann, D. Schwarz, E. Wolf, C. Herrmann, "Structural and thermodynamic characterization of Nore1-SARAH: a small, helical module important in signal transduction networks". Biochemistry 52, 1045-1054 (2013)

2012

C. Träger, M. A. Rosenblad, D. Ziehe, C. Garcia-Petit, L. Schrader, K. Kock, C. Vera Richter, B. Klinkert, F. Narberhaus, C. Herrmann, E. Hofmann, H. Aronsson, D. Schünemann, "Evolution from the Prokaryotic to the Higher Plant Chloroplast Signal Recognition Particle: The Signal Recognition Particle RNA Is Conserved in Plastids of a Wide Range of Photosynthetic Organisms", Plant Cell 24, 4819-4836 (2012)

I. C. Rosnizeck, M. Spoerner, T. Harsch, S. Kreitner, D. Filchtinski, C. Herrmann, D. Engel, B. König, H. R. Kalbitzer, "Metal-bis(2-picolyl)amine complexes as state 1(T) inhibitors of activated Ras protein", Angew. Chem. Int. Ed. 51, 10647-10651 (2012)

A. Syguda, M. Bauer, U. Benscheid, N. Ostler, E. Naschberger, S. Ince, M. Stürzl, C. Herrmann, "Tetramerisation of human guanylate binding protein 1 is mediated by coiled coil formation of the C-terminal α-helices", FEBS J. 279, 2544-2554 (2012)

A. Syguda, A. Kerstan, T. Ladnorg, F. Stüben, C. Wöll, C. Herrmann, "Immobilization of biotinylated hGBP1 in a defined orientation on surfaces is crucial for uniform interaction with analyte proteins and catalytic activity", Langmuir 28, 6411-6418 (2012

S. Weibels, A. Syguda, C. Herrmann, H. Weingärtner, "Steering the enzymatic activity of proteins by ionic liquids. A case study of the enzyme kinetics of yeast alcohol dehydrogenase", Phys. Chem. Chem. Phys. 14, 4635-4639 (2012)

M. Wehner, S. Kunzelmann, C. Herrmann, "The guanine cap of human guanylat-binding protein 1 is responsible for dimerization and self-activation of GTP hydrolysis", FEBS J. 279, 203-210 (2012)

H. Weingärtner, C. Cabrele, C. Herrmann, "How ionic liquids can help to stabilize native proteins", Phys. Chem. Chem. Phys. 14, 415-426 (2012)

2011

Constantinescu Aruxandei D, Makbul C, Koturenkiene A, Lüdemann MB, Herrmann C. "Dimerization-induced folding of MST1 SARAH and the influence of the intrinsically unstructured inhibitory domain: low thermodynamic stability of monomer.", Biochemistry 50, 10990-11000 (2011)

Bharti P, Schliebs W, Schievelbusch T, Neuhaus A, David C, Kock K, Herrmann C, Meyer HE, Wiese S, Warscheid B, Theiss C, Erdmann R. "PEX14 is required for microtubule-based peroxisome motility in human cells.", J Cell Sci. 124, 1759-1768 (2011)

2010

N. Britzen-Laurent, M. Bauer, V. Berton, N. Fischer, A. Syguda, S. Reipschläger, E. Naschberger, C. Herrmann and M. Stürzl, "Intracellular trafficking of Guanylate-binding proteins is regulated in a hierarchical manner: analogy to heteromeric G proteins", PLoS ONE 5, e14246, 1-11 (2010)

S. Karassek, C. Berghaus, M. Schwarten, C. G. Goemans, N. Ohse, G. Kock, K. Jockers, S. Neumann, S. Gottfried, C. Herrmann, R. Heumann, R. Stoll, "Ras homolog enriched in brain (Rheb) enhances apoptotic signaling", J Biol Chem;29;285(44):33979-91 (2010)

A. Kerstan, T. Ladnorg, C. Grunwald, T. Vöpel, D. Zacher, C. Herrmann, C. Wöll, "Human guanylate-binding protein 1 as a model system investigated by several surface techniques.", Biointerphases;5(4):131-8. (2010)

J. Wiethaus, A. W. Busch, K. Kock, L. I. Leichert, C. Herrmann, N. Frankenberg-Dinkel, "CpeS is a lyase specific for attachment of 3Z-PEB to Cys82 of {beta}-phycoerythrin from Prochlorococcus marinus MED4", J Biol Chem.;285 (48):37561-9 (2010)

T .Vöpel, A. Syguda, N. Britzen-Laurent, S. Kunzelmann, M. B. Lüdemann, C. Dovengerds, M. Stürzl, C. Herrmann, "Mechanism of GTPase-Activity-Induced Self-Assembly of Human Guanylate Binding Protein 1.", J Mol Biol. 2; 400(1):63-70 (2010)

I. C. Rosnizeck, T. Graf, M. Spoerner, J. Tränkle, D. Filchtinski, C. Herrmann, L. Gremer, I. R. Vetter, A. Wittinghofer, B. König, H. R. Kalbitzer, "Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes.", Angew Chem Int Ed Engl. 2010 May 17;49(22):3830-3.
"Stabilisierung eines niederaffinen Zustands für Effektoren im menschlichen Ras-Protein durch Cyclenkomplexe", Angew. Chem. 122, 3918-3922 (2010)

C. Bee, A. Moshnikova, C. D. Mellor, JE. Molloy, Y. Koryakina, B. Stieglitz, A. Khokhlatchev, C. Herrmann, "Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation.", J Biol Chem. 2010 May 21;285(21):16258-66.

D. Filchtinski, O. Sharabi, A. Rüppel, I. R. Vetter, C. Herrmann, J. M. Shifman, "What Makes Ras an Efficient Molecular Switch: A Computational, Biophysical, and Structural Study of Ras-GDP Interactions with Mutants of Raf.", J Mol Biol. 11;399(3):422-35 (2010)

M. Wehner, C. Herrmann, "Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant.", FEBS J, 277(7):1597-605 (2010)

D. Constantinescu, C. Herrmann, H. Weingärtner, "Patterns of Protein Unfolding and Protein Aggregation in Ionic Liquids", Phys. Chem. Chem. Phys. 12, 1756-1763 (2010)

Ältere

M. Hothorn, H. Neumann, E. D. Lenherr, M. Wehner, V. Rybin, P.O. Hassa, A. Uttenweiler, M. Reinhardt, A. Schmidt, J. Seiler, A.G. Ladurner, C. Herrmann, K. Scheffzek, A. Mayer, "Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase.", Science;324(5926):513-516 (2009)

T. Vöpel, S. Kunzelmann, C. Herrmann, "Nucleotide dependent cysteine reactivity of hGBP1 uncovers a domain movement during GTP hydrolysis.", FEBS Lett, 583(12):1923-7 (2009)

B. A. Ford, S. Boykevisch, C. Zhao, S. Kunzelmann, D. Bar-Sagi, C. Herrmann, N. Nassar, "Characterization of a Ras mutant with identical GDP- and GTP-bound structures", Biochemistry 48, 11449-11457 (2009)

C. S. Köster, M. Wehner, C. Herrmann, W. Kühlbrandt, O. Yildiz, "Structure and Function of the FeoB G-Domain from Methanococcus jannaschii." J. Mol. Biol. 392, 405-419 (2009)

C. Kiel, D. Filchtinski, M. Spoerner, G. Schreiber, H. R. Kalbitzer, C. Herrmann, "Improved binding of Raf to Ras-GDP is correlated with biological activity."J Biol Chem.;284(46):31893-902. (2009)

A. Brockmeier, M. Skopnik, B. Koch, C. Herrmann, W. Hengstenberg, S. Welti, K. Scheffzek, "Activity of the Enterococcus faecalis EIIA(gnt) PTS component and its strong interaction with EIIB(gnt)." Biochem Biophys Res Commun.: 388(4):630-6. (2009)

N. Albet-Torres, M. J. Bloemink, T. Barman, R. Candau, K. Frölander, M. A. Geeves, K. Golker, C. Herrmann, C. Lionne, C. Piperio, S. Schmitz, C. Veigel, A. Månsson, "Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin", J. Biol Chem. 284, 22926-22937 (2009)

M. Egerer, T. Giesemann, C. Herrmann, K. Aktories, "Auto-catalytic processing of clostridium difficile toxin B - binding of inositol hexakisphosphate." , J. Biol. Chem. 284, 3389-3395 (2009)
2008

B. Stieglitz, C. Bee, D. Schwarz, O. Yildiz, A. Moshnikova, A. Khokhlatchev, C. Herrmann, "Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.", EMBO J.;27(14):1995-2005 (2008)

D. Filchtinski, C. Bee, T. Savopol, M. Engelhard, C. F. Becker, C. Herrmann, "Probing ras effector interactions on nanoparticle supported lipid bilayers.", Bioconjug. Chem.; 19(9):1938-44 (2008)

T. Hikov, A. Rittermeier, M-B. Lüdemann, C. Herrmann M. Muhler, R. Fischer, "Preparation of ZnO colloids by pyrolysis of [MeZnO/Pr]4 in the presence of hexadecylamine and probing the surface chemistry of the nanoparticles by CO/CO2 adsorption studies followed by FTIR", J. Mater. Chem. 28, 3325-3331, (2008)

M. Vogelsgesang, B. Stieglitz, C. Herrmann, A. Pautsch, K. Aktories, "Crystal structure of the Clostridium limosum C3 exoenzyme.", FEBS Lett. ;582(7):1032-6 (2008)
2007

D. Constantinescu, H. Weingärtner, C. Herrmann, "Protein denaturation by ionic liquids and the Hofmeister series: a case study of aqueous solutions of ribonuclease A.", Angew. Chem Int. Ed. Engl.; 46(46):8887-9 (2007)

M. Spoerner, A. Nuehs, C. Herrmann, G. Steiner, H .R. Kalbitzer, "Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS.", FEBS J.;274(6):1419-33 (2007)
2006

S. Kunzelmann, G. J. K. Praefcke, C. Herrmann , "Transient kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma induced human Guanylate-Binding Protein 1 (hGBP1)", J. Biol. Chem., 281, 28627-28635 (2006)

E. Harjes, S. Harjes, S. Wohlgemuth, K .H. Müller, E. Krieger. C. Herrmann, P. Bayer, "GTP-Ras disrupts the intramolecular complex of C1 and RA domains of Nore1", Structure, 14, 881-888 (2006)

A. Ghosh, G. J. K. Praefcke, L. Renault, A. Wittinghofer, C. Herrmann ,“How Guanylate Binding Proteins achieve assembly-stimulated processive cleavage of GTP to GMP“, Nature , 440, 101-104 (2006)
2005

A. Pautsch, M. Vogelsgesang, J. Tränkle, C. Herrmann , K. Aktories, "Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme ", EMBO J. , 24, 3670-3680 (2005)

S. Kunzelmann, G. J. K. Praefcke, C. Herrmann , "Nucleotide binding and self-stimulated GTPase activity of human Guanylate-Binding Protein 1 (hGBP1) "in “Regulators and Effectors of small GTPases, Part F: Vesicular trafficking GTPases”, Methods in Enzymology , 404, 512-527 (2005)

J. H. Tränkle, C. Herrmann , “Calorimetry based approaches in analysis of protein:protein interactions ” in: Protein-Protein Interactions: A Laboratory Manual. 2 nd Edition”, ed. E. A. Golemis & P. D. Adams, Cold Spring Harbor Laboratory Press, 229-251 (2005)

S. Wohlgemuth, C. Kiel, A. Krämer, L. Serrano, A. Wittinghofer, C. Herrmann , "Recognizing and Defining true Ras Binding Domains I: Biochemical Analysis ", J. Mol. Biol. 348 , 741-758 (2005)

M. Spoerner, A. Nuehs, P. Ganser, C. Herrmann , A. Wittinghofer, H. R. Kalbitzer, "Conformational states of Ras complexed with the GTP-analogs GppNHp or GppCH 2 p: implications for the interaction with effector proteins ", Biochemistry 44, 2225-2236 (2005)

G. J. K. Praefcke, C. Herrmann , „Isotherme Titrationskalorimetrie (ITC) zur Charakterisierung biomolekularer Wechselwirkungen“, Biospektrum 11, 44-47 (2005)
2004

G. J. K. Praefcke, S. Kloep, U. Benscheid, H. Lilie, B. Prakash, C. Herrmann, "Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis", J. Mol. Biol. 344, 257-269 (2004)

A. Ghosh, R. C. Uthaiah, J. C. Howard, C. Herrmann, E. Wolf, "Crystal Structure of IIGP1: A Paradigm for Interferon-Inducible p47 Resistance GTPases", Mol. Cell 15, 727-739 (2004)

C. Kiel, L. Serrano, C. Herrmann, "A detailed thermodynamic analysis of ras/effector complex interfaces", J. Mol. Biol. 340, 1039-1058 (2004)

C. Kiel, T. Selzer, Y. Shaul, G. Schreiber, C. Herrmann "Electrostatically optimized Ras-binding Ral guanine dissociation stimulator mutants increase the rate of association by stabilizing the encounter complex", Proc. Natl. Acad. Sci. USA 101, 19223-19228 (2004)

O. Müller, E. Gourzoulidou, M. Carpintero, I.-M. Karaguni, A. Langerak, C. Herrmann, T. Möröy, H. Waldmann, "Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening", Angew. Chem. Int. Ed. 43, 450-454 (2004)

H. Waldmann, I.-M. Karaguni, M. Carpintero, E. Gourzoulidou, C. Herrmann, C. Brockmann, H. Oschkinat, O. Müller, "Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway", Angew. Chem. Int. Ed. 43, 454-458 (2004)
2003

A. Brockhinke, R. Plessow, K. Kohse-Höinghaus, C. Herrmann, "Structural changes in the Ras protein revealed by fluorescence spectroscopy", Physical Chemistry, Chemical Physics 5, 3498-3506 (2003)

R. C. Uthaiah, G. J. K. Praefcke, Jonathan C. Howard, C. Herrmann, "IIGP1, an interferon-? inducible 47 kDa GTPase of the Mouse, showing cooperative enzymatic activity and GTP-dependent multimerisation", J. Biol. Chem. 278, 29336-29343 (2003)

C. Herrmann, “Ras-effector interactions: after one decade” Current Opinion in Structural Biology 13, 122-129 (2003)

S. Hippler-Mreyen, J. P. Klare, A. A. Wegener, R. Seidel, C. Herrmann, G. Schmies, G. Nagel, E. Bamberg, M. Engel, "Probing the sensory rhodopsin II binding domain of its cognate transducer by calorimetry and electrophysiology", J. Mol. Biol. 330, 1203-1213 (2003)

L. Tickenbrock, K. Kößmeier, H. Rehmann, C. Herrmann, O. Müller, "Differences between the interaction of ?-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein", J. Mol. Biol. 327, 359-367 (2003)
2002

T. C. Marlovits, W. Haase, C. Herrmann, S. G. Aller, V. M. Unger, "FeoB – a potential prokaryotic predecessor for eukaryotic G protein-coupled membrane proteins with multiple membrane spanning domains", Proc. Natl. Acad. Sci. USA 99, 16243-16248 (2002)

M. Stumber, C. Herrmann, S. Wohlgemuth, H.R. Kalbitzer, W. Jahn, M. Geyer, "Synthesis, characterization and application of two nucleoside triphosphate analogues, GTP?NH2 and GTP?F", Eur. J. Biochem. 269, 3270-3278 (2002)

M. R. Ahmadian, A. Wittinghofer, C. Herrmann, “Fluorescence Methods in the Study of Small GTP-binding proteins” in: “GTPase Protocols: The Ras Superfamily” ed. E.J. Manser, T. Leung, Humana Press, Totowa, NJ, Methods in Molecular Biology 189, 45-63 (2002)

B. Dursina, N.H. Thomä, A. Niculae, A. Iakovenko, A. Rak, S. Albert, A.C. Ceacareanu, R. Kolling, C. Herrmann, R.S. Goody, K. Alexandrov, "Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates", Biochemistry 41, 6805-6816 (2002)

A. Brinker, C. Scheufler, F. von der Mulbe, B. Fleckenstein, C. Herrmann, G. Jung, I. Moarefi, F.U. Hartl, "Ligand discrimination by TPR domains - Relevance and selectivity of EEVD-recognition in Hsp70 center dot Hop center dot Hsp90 complexes."J. Biol. Chem., 277, 19265-19275 (2002)

T. Linnemann, C. Kiel, P. Herter, C. Herrmann, "The Activation of RalGDS can be achieved independently of its Ras-Binding Domain: Implications of an Activation Mechanism in Ras-Effector Specificity and Signal Distribution."J. Biol. Chem. 277, 7831-7837 (2002)
2001

B. Boettner, C. Herrmann, L. Van Aelst, “Ras and Rap1 interaction with the AF-6 effector target” in “Regulators and effectors of small GTPases, part F: Ras family I” ed. W. E. Balch, C. J. Der, A. Hall, Methods in Enzymology 332, 151-168 (2001)

K. Scheffzek, P. Grünewald, S. Wohlgemuth, W. Kabsch, H. Tu, M. Wigler, A. Wittinghofer, C. Herrmann, "The Ras-Byr2RBD complex: structural basis for Ras-effector recognition in yeast."Structure 9, 1043-1050 (2001)

J. Kuhlmann, C. Herrmann, “Biophysical Characterisation of the Ras Protein” in: “Bioorganic Chemistry of Biological Signal Transduction” ed. H. Waldmann, Topics in Current Chemistry 211, 61-116 (2001)

W. Gronwald, F. Huber, P. Grünewald, M. Spörner, S. Wohlgemuth, C. Herrmann, H. R. Kalbitzer, "Solution Structure of the Ras-binding domain of the protein kinase Byr2 from Schizosaccharomyces pombe."Structure 9,1029-1041 (2001)

K. Inoue, T. Maurer, H. Yamada, C. Herrmann, G. Horn, H. R. Kalbitzer, K. Akasaka, "High-pressure NMR study of the complex of a GTPase Rap1A with its effector RalGDS - A conformational switch in RalGDS revealed from non-linear pressure shifts."FEBS Letters 506, 180-184 (2001)

W. Gronwald, E. Brunner, F. Huber, M. Wenzler, C. Herrmann, H.R. Kalbitzer, "Overcoming the Problems associated with poor spectra quality of the protein kinase Byr2 using residual dipolar couplings. "Protein Science 10, 1260-1263 (2001)

M.G. Rudolph, T. Linnemann, P. Grünewald, A. Wittinghofer, I.R. Vetter, C. Herrmann, "Thermodynamics of Ras/Effector and Cdc42/Effector Interactions as Probed by Isothermal Titration Calorimetry."J. Biol. Chem. 276, 23914-23921 (2001)

M. Spörner, C. Herrmann, I. R. Vetter, H. R. Kalbitzer, A. Wittinghofer, "Dynamic properties of the Ras switch I region and its importance for binding to effectors."Proc. Natl. Acad. Sci. USA 98, 4944-4949 (2001)

C. Kiel, C. Herrmann, “Double mutant cycle analysis of Ras proteins and their effectors: Quantification of binding specificity.” In “Protein Modules in Cellular Signalling” ed. L Heilmeyer, P. Friedrich, NATO Science Series A: Life Sciences 318, 91-95 (2001)

Y. Groemping, D. Klostermeier, C. Herrmann, T. Veit, R. Seidel, J. Reinstein, "Regulation of ATPase and Chaperone cycle of DnaK from Thermus thermophilus by the nucleotide exchange factor GrpE."J. Mol. Biol. 305, 1173-1183 (2001)
2000

G. Steiner, W. Kremer, T. Linnemann, C. Herrmann, M. Geyer, H. R. Kalbitzer, "Sequence-specific resonance assignment of the Ras-binding domain of AF6."J. Biomol. NMR 18, 73-74 (2000)

B. Prakash, L. Renault, G. J. K. Praefcke, C. Herrmann, A. Wittinghofer, "Triphosphate structure of human Guanylate-binding Protein 1 and implications for nucleotide binding and GTP hydrolysis."EMBO J. 19, 4555-4564 (2000)

I. R. Vetter, F. Hofmann, S. Wohlgemuth, C. Herrmann, I. Just, "Structural Consequences of Mono-glucosylated Ha-Ras by Clostridium sordelli lethal toxin."J. Mol. Biol. 301, 1091-1095 (2000)

K. Inoue, H. Yamada, K. Akasaka, C. Herrmann, W. Kremer, T. Maurer, R. Döker, H. R. Kalbitzer, "Pressure-induced local unfolding of the Ras binding domain of RalGDS". Nature Struct. Biol. 7, 547-550 (2000)

F. Huber, W. Gronwald, S. Wohlgemuth, C. Herrmann, M. Geyer, A. Wittinghofer, H. R. Kalbitzer, "Sequential NMR assignment of the RAS-binding domain of Byr2."J. Biomol. NMR 16, 355-356 (2000)

B. Prakash, G. J. K. Praefcke, L. Renault, A. Wittinghofer, C. Herrmann, "Structure of human Guanylate Binding Protein 1 Representing a Unique Class of GTP-Binding Proteins."Nature 403, 567-571 (2000)

C. K. Weber, J. R. Slupsky, C. Herrmann, M. Schuler, U. R. Rapp, C. Block, "Mitogenic Signaling of Ras is Regulated by Differential Interaction with Raf Isozymes."Oncogene 19, 169-176 (2000)
älter

G. J. K. Praefcke, M. Geyer, M. Schwemmle, H. R. Kalbitzer, C. Herrmann, "Nucleotide Binding Characteristics of human Guanylate-binding Protein 1 (hGBP1) and Identification of the Third GTP-binding Motif"J. Mol. Biol. 292, 321-332 (1999)

J. R. Sydor, C. Herrmann, S. B. H. Kent, R. S. Goody, M. Engelhard, "Design, Total Chemical Synthesis, and Binding Properties of a [Leu-91N1-Methyl-7-azaTrp]Ras-binding domain of c-Raf-1"Proc. Natl. Acad. Sci. USA 96, 7865-7870 (1999)

I. R. Vetter, T. Linnemann, S. Wohlgemuth, M. Geyer, H. R. Kalbitzer, C. Herrmann, A. Wittinghofer, "Structural and Biochemical Analysis of Ras-Effector Signalling via RalGEF"FEBS Letters 451, 175-180 (1999)

T. Linnemann, B. K. Jaitner, M. Geyer, C. Block, H. R. Kalbitzer, A. Wittinghofer, C. Herrmann, "Thermodynamic and Kinetic Characterisation of the Interaction between the Ras Binding Domain of AF-6 and Members of the Ras Subfamily."J. Biol. Chem. 274, 13556-13562 (1999)

J. R. Sydor, M. Engelhard, A. Wittinghofer, R. S. Goody, C. Herrmann, "Transient Kinetic Studies on the Interaction of Ras and the Ras-Binding Domain of c-Raf-1 Reveal Rapid Equilibration of the Complex.", Biochemistry 37, 14292-14299 (1998)

C. Herrmann, C. Block, C. Geisen, K. Haas, C. Weber, G. Winde, T. Möröy, O. Müller, "Sulindac Sulfide Inhibits Ras Signaling", Oncogene 17, 1769-1776 (1998)

C. Herrmann, M. R. Ahmadian, F. Hofmann, I. Just, "Functional Consequences of Monoglucosylation of Ha-Ras at Effector Domain Amino Acid Threonine 35", J. Biol. Chem. 273, 16134-16139 (1998)

B. K. Jaitner, J. Becker, T. Linnemann, C. Herrmann, A. Wittinghofer, C. Block, "Discrimination of Amino Acids Mediating Ras Binding from Noninteracting Residues Affecting Raf Activation by Double Mutant Analysis"J. Biol. Chem. 272, 29927-29933 (1997)

M. Geyer, C. Herrmann, S. Wohlgemuth, A. Wittinghofer, H.R. Kalbitzer, "Structure of the Ras-Binding Domain of RalGEF and Implications for Ras Binding and Signalling", Nature Struct. Biol. 4, 694-699 (1997)

N. Nassar, G. Horn, C. Herrmann, C. Block, R. Janknecht, A. Wittinghofer, "Ras/Rap Effector Specificity determined by charge reversal", Nature Struct. Biol. 3, 723-729 (1996)

M. Geyer, T. Schweins, C. Herrmann, T. Prisner, A. Wittinghofer, H.R. Kalbitzer, "Conformational Transitions in p21 and in its Complexes with the Effector Protein Raf-RBD and the GTPase Activating Protein GAP", Biochemistry 35, 10308-10320 (1996)

C. Herrmann, N. Nassar, “Ras and its Effectors”, Prog. Biophys. Molec. Biol. 66, 1-41 (1996)

C. Block, R. Janknecht, C. Herrmann, N. Nassar, A. Wittinghofer, "Quantitative structure-activity analysis Correlating Ras/Raf Interaction in vitro to Raf Activation in vivo", Nature Struct. Biol. 3, 244-251 (1996).

C. Herrmann, G. Horn, M. Spaargaren, A. Wittinghofer, "Differential Interaction of the Ras Family GTP-binding Proteins H-Ras, Rap1A and R-Ras with the Putative Effector Molecules Raf-kinase and Ral-Guanine Nucleotide Exchange Factor", J. Biol. Chem. 271, 6794-6800 (1996)

A. Wittinghofer, C. Herrmann, “Ras-effector interactions, the problem of specificity”, FEBS Lett. 369, 52-56 (1995)

N. Nassar, G. Horn, C. Herrmann, A. Scherer, F. McCormick, A. Wittinghofer, "The 2.2 Å Crystal Structure of Truncated p21rap Complexed with the Ras Binding Domain of the Serine/Threonine Kinase, Raf, and GMPPNP", Nature 375, 554-560 (1995)

M. Schwemmle, M. F. Richter, C. Herrmann, N. Nassar, P. Staeheli, "Unexpected Structural Requirements for GTPase Activity of the Interferon-Induced MxA Protein", J. Biol. Chem. 270, 13518-13523 (1995)

M. F. Richter, M. Schwemmle, C. Herrmann, A. Wittinghofer, P. Staeheli, "Interferon-Induced MxA Protein: GTP Binding and GTP Hydrolysis Properties", J. Biol. Chem. 270, 13512-13517 (1995)

C. Herrmann, G. A. Martin, A. Wittinghofer, "Quantitative Analysis of the Complex between p21ras and the Ras-Binding Domain of the Human Raf-1 Protein Kinase", J. Biol. Chem. 270, 2901-2905 (1995)

J. Sleep, C. Herrmann, T. Barman, F. Travers, "Inhibition of ATP-Binding to Myofibrils and Acto-Myosin Subfragment 1 by Caged ATP", Biochemistry 33, 6038-6042 (1994)

C. Herrmann, C. Lionne, F. Travers, T. Barman, "A Correlation of ActoS1, Myofibrillar and Muscle Fibre ATPases", Biochemistry 33, 4148-4154 (1994)

C. Herrmann, J. Sleep, P. Chaussepied, F. Travers, T. Barman, "A Structural and Kinetic Study on Myofibrils Prevented from Shortening by Chemical Crosslinking", Biochemistry 32, 7255-7263 (1993)

C. Herrmann, J. Wray, F. Travers, T. Barman, "Effect of 2,3-Butanedione Monoxime on Myosin and Myofibrillar ATPases. An Example of an Uncompetitive Inhibitor", Biochemistry 31, 12227-12232 (1992)

C. Herrmann, M. Houadjeto, F. Travers, T. Barman, "Early Steps of the Mg-ATPase of Relaxed Myofibrils. A Comparison with Ca-Activated Myofibrils and Myosin Subfragment 1", Biochemistry 31, 8036-8042 (1992)

W. Sachs, W. Knoche, C. Herrmann, "Protonation of Triaminobenzenes in Aqueous Solution: Reactions Involving Aromatic Compounds, σ-Complexes and Cyanine Ions", J. Chem. Soc. Perkin Trans. 2, 701-710 (1991)

A. Khan-Lodi, B. H. Robinson, T. Towey, C. Herrmann, W. Knoche, U. Thesing, “Microparticle Formation in Reverse Micelles”, The Structure, Dynamics and Equilibrium Properties of Colloidal Systems, D. M. Bloor, E. Wyn-Jones, eds., Kluwer Academic Publishers, Dordrecht, 373 (1990)