main points of research

Neuronal connectivity is regulated not only during development but also in the adult brain, in response to brain activity. The small GTPase protein Ras is a universal intracellular signaling protein that may mediate such mechanisms of brain plasticity through transient activation of downstream protein phosphorylation signaling cascades. We have developed a synRas animal model expressing permanently activated Val12 Ras, selectively in neurons. Using this model we investigate if neuronal Ras activity is involved in the dynamics of dendritic spine formation in brain neurons, in the regulation of synapse number and their efficiency, in the regulation of neurogenesis in the hippocampus. The latter is thought to mediate working memory processes. We also investigate what is the molecular mechanism of Ras-mediated protection against lesion-induced neuronal degeneration. Formation of intracellular protein-protein interactions involving protein tyrosine phosphatases are studied in vivo and in vitro. The molecular mechanisms are analyzed by protein nuclear magnetic resonance structure determinations and mass spectrometric methods.

 

Legal Notice:

Prof. Heumann and his group accepts no liability, within the bounds of law, for the content of its web presence or for any third party pages given by links on its pages. The Ruhr-Universität expressly distances itself from the content of any linked pages and does not consider these pages to be its own.ss.

Head of Department:

Prof. Dr. Thomas Günther-Pomorski


Address / Contact


Ruhr-Universität Bochum
Gebäude NC 7/174
Universitätsstraße 150
 
D-44780 BOCHUM

  • Phone: +49(0)234 32 24230
  • FAX: +49(0)234 32 14105
  • Office: Mrs A. Koch
  • eMail Department: bc2@rub.de