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Science
How well do we currently understand the aggregation
of small molecules in the solid state?
Most of
intermolecular interactions are not very strong and their formation
is related to and affected by small changes in the molecular
structure and the crystallisation conditions. Continuing our
investigations on aggregation of substituted aromatic molecules in
the solid state, we study the influence and boundaries of weak
directing substituents like deuterium on the aggregation of
small molecules.
Hydrogen/deuterium (H/D)-exchange, the
smallest possible modification of a molecule, is generally seen as a
non dominating parameter in the formation of crystal
structures of chemical compounds. On the other hand, we can show
that the aggregation of specific molecules in the solid state is
very sensitive on small changes of the isotopic
substitution pattern of the molecules.
Publications
SMI-Symposium
Small Molecules in Interactions, 2012 Bochum
IIC-Conference:
Intermolecular Interactions in Crystals: Via Experiment and Theory
to Industrial Applications, 2013 Pula
in
situ Crystallization Crystallization of low
melting compounds directly on the diffractometer
FOR
618 Understanding the Aggregation of Small
Molecules Using Precise Methods - Interplay between Experiment and
Theory
RESOLV "Ruhr
Explores Solvation - Solvents as active units" | 
