Head of Department

Prof. Dr. Hermann Lübbert
Department of Animal Physiology
Faculty of Biology and Biotechnology
Building ND 5/122
Universitätsstr. 150
44780 Bochum
Germany

Tel: +49 (0)234 - 32-24338
Fax: +49 (0)234 - 32-14189
tierphysiologie@ruhr-uni-bochum.de

 

Secretary Secretary

 

Publications

 

Journal articles 1981-2019

 

Dirschka, T., Ekanayake-Bohlig, S., Dominicus, R., Aschoff, R., Herrera-Ceballos, E., Botella-Estrada, R., Hunfeld, A., Kremser, M., Schmitz, B., Lübbert, H., Puig, S. (2019): A randomized, intraindividual, non‐inferiority, Phase III study comparing daylight photodynamic therapy with BF‐200 ALA gel and MAL cream for the treatment of actinic keratosis. J Eur Acad Dermatol Venereol, 33(2), 288-297. (Abstract online) (Download)

Mecheri, B., Paris, F., Lübbert, H. (2018): Histological investigations on the dura mater vascular system of mice. Acta Histochemica, 120(8), 846-857. (Abstract online)

Morton, C.A., Dominicus, R., Radny, P., Dirschka, T., Hauschild, A., Reinhold, U., Aschoff, R., Ulrich, M., Keohane, S., Ekanayake-Bohlig, S., Ibbotson, S., Ostendorf, R., Berking, C., Gröne, D., Schulze, H.J., Ockenfels, H.M., Jasnoch, V., Kurzen, H., Sebastian, M., Stege, H., Staubach, P., Gupta, G., Hübinger, F., Ziabreva, I., Schmitz, B., Gertzmann, A., Lübbert, H., Szeimies, R.M. (2018): A randomized, multinational, noninferiority, phase III trial to evaluate the safety and efficacy of BF-200 aminolaevulinic acid gel vs. methyl aminolaevulinate. Br J Dermatol 179 (2), 309-319. (Abstract online) (Download)

Novak, B., Heesen, L., Schary, N., Lübbert, H. (2018): The influence of different illumination parameters on protoporphyrin IX induced cell death in squamous cell carcinoma cells. Photodiagnosis Photodyn Ther 21, 385-392. (Abstract online) (Download)

Kalbe, B., Schlimm, M., Wojcik, S., Philippou, S., Maßberg, D., Jansen, F., Scholz, P., Lübbert, H., Ubrig, B., Osterloh, S., Hatt, H. (2016): Olfactory signaling components and olfactory receptors are expressed in tubule cells of the human kidney. Arch Biochem Biophys 610, 8-15. (Abstract online)

Schmitz, L., Novak, B., Hoeh, A.-K., Lübbert, H., Dirschka, T. (2016): Epidermal penetration and protoporphyrin IX formation of two different 5-aminolevulinic acid formulations in ex vivo human skin. Photodiagnosis Photodyn Ther 14, 40–46. (Abstract online) (Download)

Novak, B., Peteja, M., Brueck, T., Lübbert, H. (2016): Potency of different red light sources in photodynamic induction of cell death in a squamous cell carcinoma cell line. Photodiagnosis Photodyn Ther 14, 128-130. (Abstract online) (Download)

Reinhold, U., Dirschka, T., Ostendorf, R., Aschoff, R., Berking, C., Philipp-Dormston, W.G., Hahn, S., Lau, K., Jäger, A., Schmitz, B., Lübbert, H. and Szeimies, R.-M. (2016): A randomized, double-blind, phase III, multi-centre study to evaluate the safety and efficacy of BF-200 ALA (Ameluz®) versus placebo in the field-directed treatment of mild to moderate actinic keratosis with photodynamic therapy (PDT) when using the BF-RhodoLED® lamp U. Br J Dermatol 175 (4), 696-705. (Abstract online)

Schmitz, B., Ullmer, C., Segelcke, D., Gwarek, M., Zhu, X-R., Lübbert, H. (2015): BF-1 – a novel selective 5-HT2B receptor antagonist blocking neurogenic dural plasma protein extravasation in guinea pigs. Eur J Pharmacol 751, 73-80. (Abstract online)

Hunfeld, A., Segelcke, D., Bäcker, I., Mecheri, B., Hemmer, K., Dlugosch, E., Andriske, M., Paris, F., Zhu, X.R. & Lübbert, H. (2015): Hypoxia facilitates neurogenic dural plasma protein extravasation in mice: a novel animal model for migraine pathophysiology. Sci Rep 5, 178545. (Abstract online) (Article Full Text PDF, 1686 kb)

Romaní-Aumedes, J., Canal, M., Martín-Flores, N., Sun, X., Pérez-Fernández, V., Wewering, S., Fernández-Santiago, R., Ezquerra, M., Pont-Sunyer, C., Lafuente, A., Alberch, J., Lübbert, H., Tolosa, E., Levy, OA., Greene, LA., Malagelada, C. (2014): Parkin loss of function contributes to RTP801 elevation and neurodegeneration in Parkinson's disease. Cell Death Dis (5), e1364. (Abstract online)

Tanabe, Y., Fujita, E., Hayashi, Y., Zhu, X., Lübbert, H., Mezaki, Y., Senoo, H., Momoi, T. (2013) Synaptic adhesion molecules in Cadm family at the neuromuscular junction. Cell Biol Int 37(7), 731-6. (Abstract online)

Novak, B.; Schulten, R.; Dirschka, T.; Szeimies, R.M.; Foguet, M.; Lübbert, H. (2013) Photodynamic Treatment of Actinic Keratosis Using Ameluz®: Recapitulation of Clinical Phase III Studies in the Light of Novel Preclinical Research. In: Elsai, M.L.T., Ed., Photodynamic Therapy: New Research, Chapter 4, 93-109, Nova Science Publishers, Inc., Hauppauge, NY (PDF-Version)

Dirschka, T., Radny, P., Dominicus, R., Mensing, H., Brüning, H., Jenne, L., Karl, L., Sebastian, M., Oster-Schmidt, C., Klövekorn, W., Reinhold, U., Tanner, M., Gröne, D., Deichmann, M., Simon, M., Hübinger, F., Hofbauer, G., Krähn-Senftleben, G., Borrosch, F., Reich, K., Berking, C., Wolf, P., Lehmann, P., Moers-Carpi, M., Hönigsmann, H., Wernicke-Panten, K., Hahn, S., Pabst, G., Voss, D., Foguet, M., Schmitz, B., Lübbert, H., Szeimies, R.M.; AK-CT002 Study Group; AK-CT003 Study Group (2013) Long-term (6 and 12 months) follow-up of two prospective, randomized, controlled phase III trials of photodynamic therapy with BF-200 ALA and MAL for the treatment of actinic keratosis. Br J Dermatol 168(4), 825-36. (Abstract online)(PDF-Version)

Kurtenbach, S., Wewering, S., Hatt, H., Neuhaus, E.M. and Lübbert, H. (2013) Olfaction in Three Genetic and Two MPTP-Induced Parkinson's Disease Mouse Models, PLOS ONE, 8(10), e77509. (Abstract online)

Dirschka, T., Radny, P., Dominicus, R., Mensing, H., Brüning, H., Jenne, L., Karl, L., Sebastian, M., Oster-Schmidt, C., Klövekorn, W., Reinhold, U., Tanner, M., Gröne, D., Deichmann, M., Simon, M., Hübinger, F., Hofbauer, G., Krähn-Senftleben, G., Borrosch, F., Reich, K., Berking, C., Wolf, P., Lehmann, P., Moers-Carpi, M., Hönigsmann, H., Wernicke-Panten, K., Helwig, C., Foguet, M., Schmitz, B., Lübbert, H., Szeimies, R.M. (2012) Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a multicentre, randomized, observer-blind phase III study in comparison to a registered methyl-aminolaevulinic acid cream and placebo. Br J Dermatol 166(1), 137-46. (Abstract online) (Article Full Text PDF, 233 kb)

Yanovsky, Y., Schubring, S., Fleischer, W., Gisselmann, G., Zhu, X.R., Lübbert, H., Hatt, H., Rudolph, U., Haas, H.L., Sergeeva,O.A. (2012) GABA(A) receptors involved in sleep and anaesthesia: beta1- versus beta3-containing assemblies. Pflugers Arch 463(1), 187-199. (Abstract online) (Article Full Text PDF, 780 kb)

Schulten, R., Novak, B., Schmitz, B., Lübbert, H. (2012) Comparison of the uptake of 5-aminolevulinic acid and its methyl ester in keratinocytes and skin. Naunyn Schmiedebergs Arch Pharmacol 385(10), 969-79. (Abstract online) (Article Full Text PDF, 374 kb)

Schmidt, S., Linnartz, B., Mendritzki, S., Sczepan, T., Lübbert, M., Stichel, C.C., Lübbert, H. (2011) Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria. Hum Mol Genet 20 (6), 1197-1211. (Abstract online) (Article Full Text PDF, 927 kb)

Novak, B., Schulten, R., Lübbert, H. (2011) δ-Aminolevulinic acid and its methyl ester induce the formation of Protoporphyrin IX in cultured sensory neurones. Naunyn Schmiedebergs Arch Pharmacol 384(6), 583-602. (Abstract online) (Article Full Text PDF, 1025 kb)

Sergeeva, O.A., Kletke, O., Kragler, A., Poppek, A., Fleischer, W., Schubring, S.R., Goerg, B., Haas, H.L., Zhu, X.R., Lübbert, H., Gisselmann, G., Hatt, H. (2010) Fragrant dioxane derivatives identify {beta}1 subunit-containing GABAA receptors. J Biol Chem 285(31), 23985-93. (Abstract online) (Article Full Text PDF, 2481 kb)

Szeimies, R.M., Radny, P., Sebastian, M., Borrosch, F., Dirschka, T., Krähn-Senftleben, G., Reich, K., Pabst, G., Voss, D., Foguet, M., Gahlmann, R., Lübbert, H., Reinhold, U. (2010) Photodynamic therapy with BF-200 ALA for the treatment of actinic keratosis: results of a prospective, randomized, double-blind, placebo-controlled phase III study. Br J Dermatol 386 (2), 386-394. Abstract online) (Article Full Text PDF, 271 kb)

Schönefuss, A., Wendt, W., Schattling, B., Schulten, R., Hoffmann, K., Stuecker, M., Tigges, C., Lübbert, H., Stichel, C.C. (2010) Upregulation of cathepsin S in psoriatic keratinocytes. Exp Dermatol 19(8), e80-e88. (Abstract online) (Article Full Text PDF, 271 kb)

Mendritzki, S., Schmidt, S., Sczepan, T., Zhu, X.R., Segelcke, D. and Lübbert, H. (2010) Spinal cord pathology in alpha-synuclein transgenic mice. Parkinson's Disease Volume 2010, Article ID 375462, 9 pages (Abstract online) (Article Full Text PDF, 12171 kb)

Um, J.W., Im, E., Lee, H.J., Min, B., Yoo, L., Yoo, J., Lübbert, H., Stichel-Gunkel, C.C., Cho, H., Yoon, J.B. and Chung, K.C. (2010) Parkin directly modulates 26S proteasome activity. J Neurosci 30 (35), 11805-14. (Abstract online) (Article Full Text PDF, 1441 kb)

Scheller, D., Ullmer, C., Berkels, R., Gwarek, M., Lübbert, H. (2009) The in vitro receptor profile of Rotigotine: a new agent for the treatment of Parkinson's disease. Naunyn Schmiedebergs Arch Pharmacol 379 (1), 73-86. (Abstract online)

Um, J.W., Stichel-Gunkel, C.C., Lübbert, H., Lee, G., Chung, K.C. (2009) Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Mol. Cell. Neurosci. 40(4), 421-32. (Abstract online) (Article Full Text PDF, 412 kb)

Leichsenring, A., Andriske, M., Bäcker, I., Stichel, C.C., Lübbert, H. (2009) Analgesic and anti-inflammatory effects of cannabinoid receptor agonists in a rat model of neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol 379(6), 627-636. (Abstract online) (Article Full Text PDF, 701 kb)

Wendt, W., Schulten, R., Stichel, C.C., Lübbert, H. (2009) Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model. J Neurochem 110(6), 1931-41. (Abstract online) (Article Full Text PDF, 412 kb)

Scheller, D., Stichel-Gunkel, C.C., Lübbert, H., Porras, G., Ravenscroft, P., Hill, M. and Bezard, E. (2008) Neuroprotective effects of rotigotine in the acute MPTP-lesioned mouse model of Parkinson’s disease. Neurosci Lett 432 (1), 30-34. (Article Full Text PDF, 564 kb)

Estévez, M.A., Henderson, J.A., Ahn, D., Zhu, X.R., Poschmann, G., Lübbert, H., Marx, R., Baraban, J.M. (2008) The neuronal RhoA GEF, Tech, interacts with the synaptic multi-PDZ-domain-containing protein, MUPP1. Eur. J. Neurochem. 106 (3), 1287-97. (Article Full Text PDF, 602 kb)

Leichsenring, A., Bäcker, I., Wendt, W., Andriske, M., Schmitz, B., Stichel-Gunkel, C.C., Lübbert, H. (2008) Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model. BMC Neurosci. (Abstract online) (Article Full Text PDF, 4737 kb)

Wendt, W., Lübbert, H., Stichel-Gunkel, C.C. (2008) Upregulation of cathepsin S in the aging and pathological nervous system of mice. Brain Res. 1232, 7-20. (Abstract online)

Wendt, W., Zhu, XR., Lübbert, H., Stichel, C.C. (2007) Differential expression of cathepsin X in aging and pathological central nervous system of mice. Exp. Neurol. 204 (2), 525-40. (Abstract online)

Stichel, C.C., Lübbert, H. (2007) Inflammatory processes in the aging mouse brain: Participation of dendritic cells and T-cells. Neurobiol. Aging. 28 (10), 1507-21. (Abstract online)

Stichel, C.C., Zhu, XR., Bader, V., Linnartz, B., Schmidt, B., Lübbert, H. (2007) Mono- and double-mutant mouse models of Parkinson`s disease display severe mitochondrial damage. Hum Mol Genetics, 16 (20), 3377-93. (Article Full Text PDF, 1660 kb)

Zhu, XR., Maskri, L., Herold, C., Bader, V., Stichel, C.C., Güntürkün, O., Lübbert, H. (2007) Non-motor behavioral impairments in parkin-deficient mice. Eur. J. Neurosci. 26 (7), 1902-11. (Article Full Text PDF, 425 kb)

Leichsenring, A., Linnartz, B., Zhu, XR., Lübbert, H., Stichel, C.C. (2006) Ascending neuropathology in the CNS of a mutant SOD1 mouse model of amyotrophic lateral sclerosis. Brain Res. 1096 (1), 180-195. (Abstract online)

Stichel, C.C., Schönebeck, B., Foguet, M., Siebertz, B., Bader, V., Zhu, XR., Lübbert, H. (2005) Sgk1, a member of an RNA cluster associated with cell death in a model of Parkinson`s disease. Eur. J. Neurosci. 21 (2), 301-316. (Abstract online)

Bader, V., Zhu, XR., Lübbert, H., Stichel, C.C., (2005) Expression of DJ-1 in the adult mouse brain. Brain Res. 1041 (1), 102-11. (Abstract online)

Schönebeck, B., Bader, V., Zhu, XR., Schmitz, B., Lübbert, H., Stichel, C.C., (2005) Sgk1, a cell survival response, in neurodegenerative diseases. Mol. Cell. Neurosci. 30 (2), 249-64. (Abstract online)

Kühn, K., Zhu, XR., Lübbert, H., Stichel, C.C. (2004) Parkin expression in the developing mouse. Dev. Brain Res. 149 (2), 131-142. (Abstract online)

Maskri, L., Zhu, XR., Fritzen, S., Kühn, K., Ullmer, C., Engels, P., Andriske, M., Stichel, C.C., Lübbert, H. (2004) Influence of different promoters on the expression pattern of mutated human alpha-synuclein in transgenic mice. Neurodegenerative dis. 1 (6), 255-65. (Article Full Text PDF, 1510 kb)

Simmen, U., Bobirnac, I., Ullmer, C., Lübbert, H., Berger Büter, K., Schaffner, W., Schoeffter, P. (2003) Antagonist effect of pseudohypericin at CRF receptors. Eur. J. of Pharmacol. 458: 251-256. (Abstract online) 

Kühn, K., Wellen, J., Link, N., Maskri, L., Lübbert, H., Stichel, C.C. (2003) The mouse MPTP model: gene expression changes in dopaminergic neurons. Eur. J. Neurosci. 17: 1-12. (Abstract online)

Sitek, B., Poschmann, G., Schmidtke, K., Ullmer, C., Maskri, L., Andriske, M., Stichel-Gunkel, C.C., Zhu, X.R., and Lübbert, H. (2003) Expression of MUPP1 protein in mouse brain. Brain Res. 970(1-2): 178-87. (Abstract online)

Samochocki M, Höffle A, Fehrenbacher A, Jostock R, Ludwig J, Christner C, Radina M, Zerlin M, Ullmer C, Pereira EF, Lübbert H, Albuquerque EX, Maelicke A (2003) Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors. J Pharmacol Exp Ther. 305(3):1024-36. (Abstract online) (Article Full Text PDF 394 kb)

Segurado R, Detera-Wadleigh SD, Levinson DF, Lewis CM, Gill M, Nurnberger JI Jr, Craddock N, DePaulo JR, Baron M, Gershon ES, Ekholm J, Cichon S, Turecki G, Claes S, Kelsoe JR, Schofield PR, Badenhop RF, Morissette J, Coon H, Blackwood D, McInnes LA, Foroud T, Edenberg HJ, Reich T, Rice JP, Goate A, McInnis MG, McMahon FJ, Badner JA, Goldin LR, Bennett P, Willour VL, Zandi PP, Liu J, Gilliam C, Juo SH, Berrettini WH, Yoshikawa T, Peltonen L, Lönnqvist J, Nöthen MM, Schumacher J, Windemuth C, Rietschel M, Propping P, Maier W, Alda M, Grof P, Rouleau GA, Del-Favero J, Van Broeckhoven C, Mendlewicz J, Adolfsson R, Spence MA, Luebbert H, Adams LJ, Donald JA, Mitchell PB, Barden N, Shink E, Byerley W, Muir W, Visscher PM, Macgregor S, Gurling H, Kalsi G, McQuillin A, Escamilla MA, Reus VI, Leon P, Freimer NB, Ewald H, Kruse TA, Mors O, Radhakrishna U, Blouin JL, Antonarakis SE, Akarsu N (2003): Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: bipolar disorder. Am. J. Hum. Genet. 73, 49-62. (Abstract online) (Article Full Text PDF 804 kb)

Maelicke, A., Lübbert, H. (2002) DEPD, a high resolution gene expression profiling technique cabable of identifying new drug targets in the central nervous system. J. Recept. Signal. Transduct. Res. 22: 283-295. (Abstract online)

Bécamel, C., Figge, A., Poliak, S., Dumuis, A., Peles, E., Bockaert, J.,  Lübbert H. and Ullmer, C. (2001) Interaction of Serotonin 5-Hydroxytryptamine Type 2C Receptors with PDZ10 of the Multi-PDZ Domain Protein MUPP1. J. Biol. Chem. 276: 12974-12982. (Abstract online) (Article Full Text PDF 1955 kb)

Kelsoe JR, Spence MA, Loetscher E, Foguet M, Sadovnick AD, Remick RA, Flodman P, Khristich J, Mroczkowski-Parker Z, Brown JL, Masser D, Ungerleider S, Rapaport MH, Wishart WL, Lübbert H (2001) A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22. Proc. Natl. Acad. Sci. USA 98: 585-590. (Abstract online) (Reprint PDF version 122 kb)

Zwilling, S., Hoffmann, R. und Lübbert, H. (2001) Genomics und Genprofil-Analyse. Nachrichten aus der Chemie 49: 324-327.

Stichel, C.C., Augustin, M., Kühn, K., Zhu, X.-R., Engels, P., Ullmer, C., Lübbert, H. (2000) Parkin expression in the adult mouse brain. Eur. J. Neurosci. 12: 4181-4195. (Abstract online) (Article Full Text PDF 1047 kb)

Pulver, A.E. plus 134 Authors including H. Lübbert (1998) Additional support for schizophrenia linkage findings on chromosomes 6 and 8: a multicenter study. Am. J. Med. Genetics.

Hulley, P., Schachner, M., and Lübbert, H. (1998) L1 neural cell adhesion molecule is a survival factor for fetal dopaminergic neurons. J. Neurosci. Res. 53: 129-134. (Abstract online) (Article Full Text PDF 112 kb)

Ullmer, C., Schmuck, K., Figge, A. and Lübbert, H. (1998) Cloning and characterization of MUPP1, a novel PDZ domain protein. FEBS Lett. 424: 63-68. (Abstract online) (Article Full Text PDF 713 kb)

Schott, K., Lübbert, H., Schloss, P., Grosse-Tebbe, S., Batra, A., Bartels, M., and Buchkremer, G. (1997) Is there an immunpathology of the serotonergic synapse in mental disorder? Adv. Biol. Psychiatry 18: 13-17.

Meyer, A. H., Schmuck, K., Morel, C., Lübbert, H., and Engels, P. (1997) Localization of a gene coding for the phospholipase A2-L subtype (PLA2L) to human chromosome 8q24-qter. Genomics 38: 435-437. (Abstract online)

Meyer, A., Ullmer, C., Schmuck, K., Morel, C., Wishart, W., Lübbert, H., and Engels, P. (1997) Localization of the human CRF2-receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis. Genomics 40: 189-190. (Abstract online)

Schoeffter, P., Ullmer, C., Bobirnac, I., Gabbiani, G. and Lübbert, H. (1996) Functional, endogenously expressed 5-hydroxytryptamine 5-HT7 receptors in human vascular smooth muscle cells. Br. J. Pharmacol. 117: 993-994. (Abstract online)

Ullmer, C., Boddeke, H., Schmuck, K. and Lübbert, H. (1996) 5-HT2B receptor-mediated calcium release from ryanodine-sensitive intracellular stores in human pulmonary artery endothelial cells. Br. J. Pharmacol. 117: 1081-1088. (Abstract online)

Horton, Y.M., Lübbert, H. and Houslay, M.D. (1996) Localisation of the gene for the human serotonin 5-HT2B receptor to human chromosome 2. Mol. Membrane Biol. 13: 29-31. (Abstract online)

Holm, J., Hillenbrand, R., Steuber, V., Moos, M., Lübbert, H., Montag, D., and Schachner, M. (1996) Structural features of a close homolog of L1 (CHL1) in the mouse: a novel member of the L1 family of neural recognition molecules. Eur. J. Neurosci. 8: 1613-1629.  (Abstract online)

Schmuck, K., Ullmer, C., Probst, A., Kalkman, H., and Lübbert, H. (1996) Activation of meningeal 5-HT2B receptors: An early step in the generation of migraine headache? Eur. J. Neurosci. 8: 959-967.  (Abstract online)

Ullmer, C., Abdel'Al, S., Engels, P. and Lübbert, H. (1996) Distribution of 5-HT4 receptor mRNA in the rodent brain. Naunyn-Schmiedebergs Arch. Pharmacol. 354: 210-212. (Abstract online) Kistner, A., Gossen, M., Zimmermann, F., Ullmer, C., Lübbert, H., and Bujard, H. (1996) Doxycline-mediated, quantitative and tissue-specific control of gene expression in transgenic mice. Proc. Natl. Acad. Sci. USA 93: 10933-10938. (Abstract online)

Lübbert, H. and Boddeke, H. (1996) Trends: Molekulare Medizin. Nachrichten aus Chemie, Technik und Laboratorium, February.

Bruns, C., Raulf, F., Hoyer, D., Schloos, J., Lübbert, H., and Weckbecker, G. (1996) Binding properties of somatostatin receptor subtypes. Metabolism 45 (Suppl. 1): 17-20. (Abstract online)

Bruns, C., Weckbecker, G., Raulf, F., Lübbert, H., and Hoyer, D. (1995) Characterization of somatostatin receptor subtypes. Ciba Found. Symp. 190: 89-101, discussion 101-10. (Abstract online)

Engels, P., Müller, T., Sullivan, M. and Lübbert, H. (1995) Molecular cloning and functional expression in yeast of a novel human cAMP-specific phosphodiesterase subtype. FEBS Lett. 358: 305-310. (Abstract online) (Article Full Text PDF 762 kb)

Kaupmann, K., Bruns, C., Raulf, F., Weber,H.P., Mattes, H. and Lübbert, H. (1995) Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptor. EMBO J. 14: 727-735. (Abstract online) Hoyer, D., Pérez, J., Schoeffter, P., Langenegger, D., Schüpbach, E., Kaupmann, K., Lübbert, H., Bruns, C., and Reubi, J.C. (1995) Pharmacological identity between somatostatin SS-2 binding sites and SSTR-1 receptors. Euro. J. Pharmacol. 289: 163-173. (Abstract online)

Schoeffter, P., Pérez, J., Langenegger, D., Schüpbach, E., Lübbert, H., Bruns, C. and Hoyer, D., (1995) Characterization and distribution of somatosta-tin SS-1 and SRIF-1 binding sites in rat brain: Identity with SSTR-2 receptors. Eur. J. Pharmacol. 289: 163-173. (Abstract online)

Engels, P., Abdel'Al, S., Hulley, P. and Lübbert, H. (1995) Brain distribution of four rat homologues of the drosophila dunce cAMP phosphodiesterase. J. Neurosci. Res. 1: 169-178. (Abstract online)

Kalkman, H., Ullmer, C., Schmuck, K. and Lübbert, H. (1995) The role of 5-HT in the initiation of migraine. In: Serotonin in the central nervous system and periphery, A. Takada and G. Curzon, eds. 241-244.

Schoeffter, P., Ullmer, C., Gutierrez, M., Weitz-Schmidt, G. and Lübbert, H. (1995) Functional Serotonin 5-HT1D receptors and 5-HT1D receptor mRNA expression in human umbilical vein endothelial cells. Naunyn-Schmiedebergs Arch. Pharmacol. 352: 580-582. (Abstract online)

Ullmer, C., Schmuck, K., Kalkman, H. and Lübbert, H. (1995) Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 317, 215-221. (Abstract nline)

Pérez, J., Probst, A., Lübbert, H. and Hoyer, D. (1995) Expression of four somatostatin receptor mRNAs in the human brain. Neuroscience, in press.

Hulley, P., Hartikka, J. and Lübbert, H. (1995) Cyclic AMP promotes the survival of dopaminergic neurons in vitro and protects them from the toxic effects of MPP+. J. Neural. Transm. Suppl. 46: 217-228. (Abstract online)

Hulley, P., Hartikka, J., Abdel'Al, S., Engels, P., Buerki, H.-R., Wiederhold, K.-H., Müller, T., Kelly, P., Lowe, D. and Lübbert, H. (1995) Inhibitors of type IV phosphodiesterases reduce the toxicity of MPTP in substantia nigra neurons in vivo. Eur. J. Neurosci. 7(12): 2431-2440. (Abstract online)

Pérez, J., Rigo, M., Kaupmann, K., Bruns, C., Yasuda, K., Bell, G.I., Lübbert, H. and Hoyer, D. (1994) Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNAs in rat brain by in situ hybridization. Naunyn-Schmiedebergs Arch. Pharmacol. 349: 145-160. (Abstract online)

Lübbert, H. (1994) Trends: Neurobiochemie. Nachrichten aus Chemie, Technik und Laboratorium 42: 174-177.

Schmuck, K., Ullmer, C., Engels, P. and Lübbert, H. (1994) Cloning and functional characterization of the human 5-HT2B serotonin receptor. FEBS Lett. 342: 85-90. (Abstract online)

Bruns, C., Weckbecker, G., Raulf, F., Kaupmann, K., Schöffter, P., Hoyer, D. and Lübbert, H. (1994) Molecular pharmacology of somatostatin-receptor subtypes. Ann. N. Y. Acad. Sci. 733: 138-146.

Hoyer, D., Lübbert, H. and Bruns, C. (1994) Molecular pharmacology of somatostatin receptor subtypes. Naunyn-Schmiedebergs Arch. Pharmacol. 350: 441-453.  (Abstract online)

Lübbert, H. (1994) Monoaminergic neurons and their receptors: Medical implications. Futura 3/94: 144-151.

Engels, P., Fichtel, K. and Lübbert, H. (1994) Expression and regulation of human and rat phosphodiesterase type IV isogenes. FEBS Lett. 350: 291-295. (Abstract online) Bruns, C., Weckbecker, G., Raulf, F., Kaupmann, K., Schoeffter, P., Hoyer, D. and Lübbert, H. (1994) Molecular pharmacology of somatostatin-receptor subtypes. Ann. N. Y. Acad. Sci. 733: 138-146.

Kluxen, F.W. and Lübbert, H. (1993) Maximal expression of recombinant cDNAs in COS cells for the use in expression cloning. Anal. Biochem. 208 (2): 352-356. (Abstract online)

Foguet, M., Hartikka, J., Schmuck, K. and Lübbert, H. (1993) Long-term regulation of serotonergic activity in the rat brain via activation of protein kinase A. EMBO J. 12, 903-910. (Abstract online)

Lübbert, H. (1993) Jahresrückblick Neurobiochemie. Nachrichten aus Chemie, Technik und Laboratorium 41: 191-193.

Parekh, A.B., Foguet, M., Lübbert, H. and Stühmer, W. (1993) Calcium oscillations in Xenopus oocytes induced by expression of a new 5-hydroxytryptamine receptor: a wo-electrode voltage-clamp study. J. Physiol. 469: 653-671. (Abstract online)

Kaupmann, K., Bruns, C., Hoyer, D., Seuwen, K., and Lübbert, H. (1993) Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. FEBS Lett. 331: 53-59. (Abstract online)

Bruns, C., Rohrer, L., Raulf, F., Kaupmann, K., Schüle, R., Hoyer, D. and Lübbert, H. (1993) Characterization of SRIF receptor subtypes. In: Molecular and Clinical Advances in Pituitary Disorders: Proceedings of the 3rd International Pituitary Congress (S. Melmet, ed.). Endocrine Research and Education Inc., Los Angeles, pp 299-305.

Foguet, M., Nguyen, H., Le, H. and Lübbert, H. (1992) Structure of the mouse 5-HT1C, 5-HT2 and stomach fundus serotonin receptor genes. Neuroreport 3: 345-348. (Abstract online)

Kluxen, F.-W., Bruns, Ch., and Lübbert, H. (1992) Expression cloning and characterization of a rat brain somatostatin receptor. Proc. Natl. Acad. Sci. USA 89: 4618-4622. (Abstract online)

Hartikka, J., Staufenbiel, M. and Lübbert, H. (1992) Cyclic AMP, but not basic FGF, increases the in vitro survival of mesencephalic dopaminergic neurons and protects them from MPP+-induced degeneration. J. Neurosci. Res. 32: 190-201. (Abstract online)

Gaul, G. and Lübbert, H. (1992) Cortical astrocytes activated by basic fibroblast growth factor secrete molecules that stimulate differentiation of mesence-phalic dopaminergic neurons. Proc. R. Soc. Lond. B. Biol. Sci. 249 (1324): 57-63.  (Abstract online)

Foguet, M., Hoyer, D., Pardo, L.A., Pareck, A., Kluxen, F.W., Kalkman, H.O., Stühmer, W. and Lübbert, H. (1992) Cloning and functional characterization of the rat stomach fundus serotonin receptor. EMBO J. 11: 3481-3487. (Abstract online)

Gaul, G., Dutley, F., Frei, K., Foguet, M. and Lübbert, H. (1992) APP RNA splicing is not affected by differentiation of neurons and glia in culture. FEBS Lett. 307 (3): 329-332. (Abstract online) Foguet, M. and Lübbert, H. (1992) Rapid and precise construction of synthetic genes. BioTechniques 13: 674-675.

Yu, L., Nguyen, H., Le, H., Bloem, L.J., Kozak, C.A., Hoffman, B.J., Sn-ut-ch, T.P., Lester, H.A., Davidson, N. and Lübbert, H. (1991) The mouse 5-HT1C receptor contains eight hydrophobic regions and is X-linked. Brain. Res. Mol. Brain Res. 11: 143-149. (Abstract online)

Nguyen, H., Le, H., Lee, R.Y., Staufenbiel, M., Palacios, J.M., Mengod, G. and Lübbert, H. (1991) Does alternative exon usage contribute to serotonin receptor heterogeneity? Neurochem. Int. 19:433-436.

Hagenbuch, B., Stieger, B., Foguet, M., Lübbert, H., and Meier, P.J. (1991) Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc. Natl. Acad. Sci. USA 88 (23): 10629-10633. (Abstract online)

Mengod, G., Nguyen, H., Le, H., Waeber, C., Lübbert, H., and Palacios, J.M. (1990) The distribution and cellular localization of the serotonin 1C receptor mRNA in the rodent brain examined by in situ hybridization histochemistry. Comparison with receptor binding distribution. Neuroscience 35: 577-591.  (Abstract online)

Hagenbuch, B., Lübbert, H., Stieger, B., and Meier, P. (1990) Expression of the hepatocyte Na/bile acid cotransporter in Xenopus laevis oocytes. J. Biol. Chem. 265: 5357-5360. (Abstract online)

Beckh, S., Noda, M., Lübbert, H. and Numa, S. (1989) Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EMBO J. 8 (12): 3611-3616. (Abstract online)

Lübbert, H. (1988) Expression-cloning and analysis of the serotonin 1C receptor from mouse brain. In: NATO Advanced Science Institutes Series 1988: Molecular biology of neuroreceptors and ion channels (A. Maelicke, ed.), 149-161.

Lübbert, H., Snutch, T.P., Dascal, N., Lester, H.A., and Davidson, N. (1987) Rat brain 5-HT1C receptors are encoded by a 5-6 kb mRNA size-class and functionally expressed in injected Xenopus oocytes. J. Neurosci. 7 (4): 1159-1165. (Abstract online)

Lübbert, H., Hoffman, B.J., Snutch, T.P., van Dyke, T., Levine, A.J., Hartig, P.R., Lester, H.A. and Davidson, N. (1987) cDNA cloning of a serotonin 5-HT1C  receptor by electrophysi-ological assays of mRNA-injected Xenopus oocytes. Proc. Natl. Acad. Sci. 84 (12): 4332-4336. (Abstract online)

Goldin A.L., Snutch, T.P., Lübbert, H., Dowsett, A., Marshall, J., Auld, V., Downey, W., Fritz, L., Lester, H.A., Dunn, R., Catterall, W.A., and Davidson, N. (1986) Messenger  RNA coding for only the alpha-subunit of the rat brain Na channel is sufficient for expression of functional channels in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 83 (19): 7503-7507. (Abstract online)

Snutch, T.P., Leonard, J.P., Nargeot, J., Lübbert, H., Davidson, N., and Lester H.A. (1986) Characterization of voltage-gated calcium channels in Xenopus oocytes after injection of RNA from electrically excitable  tissue. In: Soc. Gen. Physiol. 40th ann. Symp. (1986) Cell calcium and the control of membrane transport.

Dascal, N., Ifune, C., Hopkins, R., Snutch, T.P., Lübbert, H., Davidson, N., Simon, M.I., and Lester, H.A.(1986) Involvement of a GTP-binding protein in mediation of seroto-nin  and acetylcholine responses in Xenopus oocytes injected with rat brain messenger RNA. Mol. Brain Res. 1: 201-209. (Abstract online)

Knebel,  D., Lübbert, H., and Doerfler, W. (1985) The promoter of the late p10 gene in the insect nuclear polyhedrosis virus Autographa californica: activation by viral gene products and sensitivity to DNA methylation. EMBO J. 4 (5): 1301-1306. (Abstract online) (Article Full Text PDF 1549 kb)

Dascal,  N., Snutch, T.P., Lübbert, H., Davidson, N., and Lester, H.A. (1985) Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes. Science 231 (4742): 1147-1150. (Abstract online)

Lübbert, H. and Doerfler, W. (1984) Mapping of early and late transcripts encoded by the Autographa  californica Nuclear Polyhedrosis Virus genome: Is viral RNA spliced? J. Virol. 50: 497-506.

Lübbert, H. and Doerfler, W. (1984) Transcription of overlapping sets of RNAs from the genome of Autographa californica Nuclear Polyhedrosis Virus: A novel method for mapping RNA. J. Virol. 52 (1): 255-265. (Abstract online) (Article Full Text PDF 2905 kb)

Esche,  H., Lübbert, H., Siegmann, B., and Doerfler, W. (1982) The translational map of the Autographa californica Nuclear Polyhedrosis Virus genome. EMBO J. 1 (12): 1629-1633. (Abstract online)

Lübbert, H., Krukzek, I., Tjia, S., and Doerfler, W. (1981) The cloned EcoRI fragments of Autographa californica Nuclear Polyhedrosis Virus DNA. Gene 6: 343-345.