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Toxikologie und Gefahrstoffrecht

Crystal engineering - Chemistry beyond the molecule

F-Praktikum für Synthesechemie

Allgemeines chemisches Einführungspraktikum für Biochemiker

pix Lehrstuhl für Anorganische Chemie I
- Bioanorganische Chemie -

Dr. Klaus Merz
Entdeckungen 1 Entdeckungen 2 Entdeckungen 3 Entdeckungen 4 Entdeckungen 5
Dr. Klaus Merz


Tätigkeit: Akademischer Direktor
Raum:       NC 3/74
Telefon:    0234-32-24187

Crystal Engineering
How well do we currently understand the aggregation of small molecules in the solid state?
Most of intermolecular interactions are not very strong and their formation is related to and affected by small changes in the molecular structure and the crystallisation  conditions.

Similarity observations read more

Multicomponent crystals read more

Polymorphism read more


Multicomponent crystals 

5-fluorouracil is an antineoplastic API, administered orally and as an injection to treat skin, colorectal, breast, gastrointestinal, and ovarian cancers.
5-fluorouracil is an interesting molecular building block not only from a pharmaceutical point of view but also from the point of view of Crystal Engineering. The simultaneous presence of hydrogen donors and acceptors allows the formation of a wide variety of multicomponent systems. With focus on pharmaceutical applications, co-crystalline 5-fluorouracil compounds with the nontoxic co-formers succinic acid and adipic acid could be synthesized and characterized.

D. D. Enkelmann, J. Handelmann, C. Schauerte, K. Merz, CrystEngComm, 21 (2019), 2130.