News & Views

People with increased risk of Alzheimer’s have deficits in navigating




Alzheimer’s patients develop severe symptoms of spatial disorientation as the disease progresses and are unable to find even the simplest ways. An international research team headed by Anne Bierbrauer, Dr. Lukas Kunz, Dr. Carlos Gomez and Professor Nikolai Axmacher from Ruhr-Universität Bochum and Universitätsklinikum Freiburg now reports that problems in spatial navigation can also be detected in people with a genetic risk for Alzheimer’s. Their article was published in the journal Science Advances, released online on 28 August 2020. The team from Bochum, Freiburg, Dortmund, Sevilla, Madrid, Parma and Brussels explored the ability of path integration.

current press release


Unmasking selective path integration deficits in Alzheimer’s disease risk carriers


Bierbrauer A, Kunz L, Gomes CA, Luhmann M, Deuker L, Getzmann S, Wascher E, Gajewski P, Hengstler JG, Fernandez-Alvarez M, Atienza M, Cammisuli DM, Bonatti F, Pruneti C, Percesepe A, Bellaali Y, Hanseeuw B, Strange BA, Cantero JL, Axmacher N.

Science Advances, Vol. 6, no. 35, eaba1394 DOI: 10.1126/sciadv.aba1394



News & Views


Tracking Selective Rehearsal and Active Inhibition of Memory Traces in Directed Forgetting

An essential mechanism memory is not only to remember relevant information, but also to forget irrelevant information. Whether forgetting,   i.e. selective inhibition irrelevant information, is an active process, or a mere byproduct of omitted rehearsal remained debated. Here, using EEG and multivariate analysis methods we find clear evidence that humans employ active inhibition mechanisms to attenuate memory traces in oder to voluntary forget unwanted information“.



Fellner MC, Waldhauser GT, Axmacher N.

Curr Biol. 2020 Jul 6;30(13):2638-2644.e4. doi: 10.1016/j.cub.2020.04.091. Epub 2020 May 21. PMID: 32442462.

ERC Consolidator Grant for neuroscientists from Bochum

With the funding from the European Research Council, Nikolai Axmacher wants to find out how the brain manages spatial navigation. The results are also relevant for Alzheimer's research.



Colloquium IB 6/ 127


Winter Semester Thursday 14- 16 p.m.




was cancelled





Ruhr-Universität Bochum

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