Publications 2021-2025

  • S. Neumann, K. Kuteykin-Teplyakov and R. Heumann (2024).
    Neuronal protection by Ha-RAS-GTPase signaling through selective downregulation of plasmalemmal voltage-dependent anion channel-1.
    International Journal of Molecular Sciences 25(5): 3030
    doi: 10.3390/ijms25053030
    Abstract      Press Release
     
  • C. Merritt, E.M. Chun, R.J. Fattah, L.M. Silva, Q.Q. Ma, M. Moayeri, D. Paliga, S. Neumann, R. Heumann, S.H. Leppla, T.H. Bugge (2022).
    Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry.
    Journal of Biological Chemistry
    doi: 10.1016/j.jbc.2021.101467
    Abstract
     
  • Heumann R., Neumann S., Secret E., Schöneborn H., Raudzus F. (2021).
    Cytoplasmic coupling and translocation of protein-functionalized magnetic nanoparticles into neurite tips of human dopaminergic cells.
    FEBS OPEN BIO 11: 209

Publications 2016-2020

  • Raudzus F., Schöneborn H., Neumann S., Secret E., Michel A., Fresnais J., Brylski O., Ménager C., Siaugue J.-M. and Heumann R. (2020).
    Magnetic spatiotemporal control of SOS1 coupled nanoparticles for guided neurite growth in dopaminergic single cells.
    Sci. Rep. 10: 22452
    doi: 10.1038/s41598-020-80253-w
    Abstract
     
  • Bongaerts M., Aizel K., Secret E., Jan A., Nahar T., Raudzus F., Neumann S., Telling N., Heumann R., Siaugue J.-M., Ménager C., Fresnais J., Villard C., El Haj A., Piehler J., Gates M.A. and Coppey M. (2020).
    Parallelized manipulation of adherent living cells by magnetic nanoparticles-mediated forces.
    Int. J. Mol. Sci. 21: 6560
    doi: 10.3390/ijms21186560
    Abstract
     
  • Schöneborn H., Raudzus F., Secret E., Otten N., Michel A., Fresnais J., Ménager C., Siaugue J.-M., Zaehres H., Dietzel I.D. and Heumann R. (2019).
    Novel tools towards magnetic guidance of neurite growth: (I) Guidance of magnetic nanoparticles into neurite extensions of induced human neurons and in vitro functionalization with RAS regulating proteins.
    J. Funct. Biomater. 10(3): 32
    doi: 10.3390/jfb10030032
    Abstract
     
  • Paliga D., Raudzus F., Leppla S.H., Heumann R. and Neumann S. (2019).
    Lethal factor domain-mediated delivery of Nurr1 transcription factor enhances tyrosine hydroxylase activity and protects from neurotoxin-induced degeneration of dopaminergic cells.
    Mol. Neurobiol. 56(5): 3393–3403
    doi: 10.1007/s12035-018-1311-6
    Abstract
     
  • Kock G., Dicks M., Yip K.T., Kohl B., Pütz S., Heumann R., Erdmann K.S. and Stoll R. (2018).
    Ligand recognition by PDZ3 in murine protein tyrosine phosphatase PTPN13.
    J. Mol Biol. 430: 4275–4292
    doi: 10.1016/j.jmb.2018.08.023
    Abstract
     
  • Heumann, R. (2018).
    Highlight Issue “Molecular Basis of Life 2017”.
    Biol. Chem. 399(7): 621–622
    doi: 10.1515/hsz-2018-0248
    Abstract
     
  • Serdar M., Herz J., Kempe K., Winterhager E., Jastrow H. and Heumann R., Felderhoff-Müser U. and Bendix I. (2018).
    Protection of oligodendrocytes through neuronal overexpression of the small GTPase Ras in hyperoxia-induced neonatal brain injury.
    Front. Neurol. 9: 175
    doi: 10.3389/fneur.2018.00175
    Abstract
     
  • Schöneborn H., Raudzus F., Coppey M., Neumann S. and Heumann, R. (2018).
    Perspectives of RAS and RHEB GTPase signaling pathways in regenerating brain neurons.
    Int. J. Mol. Sci. 19(12): 4052
    doi: 10.3390/ijms19124052
    Abstract
     
  • Athanasopoulos P.S., Heumann R. and Kortholt A. (2018).
    The role of (auto)-phosphorylation in the complex activation mechanism of LRRK2.
    Biol. Chem. 399(7): 643–647
    doi: 10.1515/hsz-2017-0332
    Abstract
     
  • Serchov T. and Heumann R. (2018).
    Ras Activity tunes the period and modulates the entrainment of the suprachiasmatic clock.
    Front. Neurol. 8: 264
    doi: 10.3389/fneur.2017.00264
    Abstract
     
  • Schöpel M., Potheraveedu V.N., Al-Harthy T., Abdel-Jalil R., Heumann R. and Stoll R. (2017).
    The small GTPases Ras and Rheb studied by multidimensional NMR spectroscopy: structure and function.
    Biol. Chem. 398(5–6): 577–588
    doi: 10.1515/hsz-2016-0276
    Abstract
     
  • Potheraveedu V.N., Schöpel M., Stoll R. and Heumann, R. (2017).
    Rheb in neuronal degeneration, regeneration, and connectivity.
    Biol. Chem. 398(5–6): 589–606
    doi: 10.1515/hsz-2016-0312
    Abstract
     
  • Islam M.S., Nolte H., Jacob W., Ziegler A.B., Pütz S., Grosjean Y., Szczepanowska K., Trifunovic A., Braun T., Heumann H., Heumann R., Hovemann B., Moore D.J. and Krüger M. (2016).
    Human R1441C LRRK2 regulates the synaptic vesicle proteome and phosphoproteome in a Drosophila model of Parkinson's disease.
    Hum. Mol. Genet. 25: 5365–5382
    doi: 10.1093/hmg/ddw352
    Abstract
     
  • Athanasopoulos P.S., Jacob W., Neumann S., Kutsch M., Wolters D., Tan E.K. Bichler, Z. Herrmann, C. and Heumann R. (2016).
    Identification of protein phosphatase 2A as an interacting protein of leucine-rich repeat kinase 2.
    Biol. Chem. 397(6): 541–554
    doi: 10.1515/hsz-2015-0189
    Abstract
     
  • Heumann R. (2016).
    Highlight: Perspectives of molecular neuroscience in health and disease.
    Biol. Chem. 397(3): 175
    doi: 10.1515/hsz-2018-0248
    Abstract
     
  • Serdar M., Herz J., Kempe K., Lumpe K., Reinboth B.S., Sizonenko S.V., Hou X., Herrmann R., Hadamitzky M., Heumann R., Hansen W., Sifringer M., van de Looij Y., Felderhoff-Müser U. and Bendix I. (2016).
    Fingolimod protects against neonatal white matter damage and long-term cognitive deficits caused by hyperoxia.
    Brain Behav. Immun. 52: 106–119
    doi: 10.1515/hsz-2015-0189
    Abstract
     
  • Serchov T., Heumann R., van Calker D. and Biber K. (2016).
    Signaling pathways regulating Homer1a expression: implications for antidepressant therapy.
    Biol. Chem. 397(3): 207–214
    doi: 10.1515/hsz-2015-0267
    Abstract
     

Publications 2011-2015

  • Serchov T., Jilg A., Wolf C.T., Radtke I., Stehle J. and Heumann R. (2015).
    Ras activity oscillates in the mouse suprachiasmatic nucleus and modulates circadian clock dynamics.
    Mol. Neurobiol. 53: 1843–1855
    doi: 10.1007/s12035-015-9135-0
    Abstract
     
  • Heumann R., Moratalla R., Herrero M.T., Chakrabarty K., Drucker-Colín R., Garcia-Montes J.R., Simola N. and Morelli M. (2014).
    Dyskinesia in Parkinson's disease: mechanisms and current non pharmacological interventions.
    J. Neurochem. 130(4): 472–489
    doi: 10.1111/jnc.12751
    Abstract
     
  • Schöpel M., Jockers K.F., Düppe P.M., Autzen J., Potheraveedu V.N., Ince S., Yip K.T., Heumann R., Herrmann C., Scherkenbeck J. and Stoll R. (2013).
    Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: Implications for GTPase-selective antagonists.
    J. Med. Chem. 56(23): 9664–9672
    doi: 10.1021/jm401291q
    Abstract
     
  • Ehrkamp A., Herrmann C., Stoll R.I. and Heumann R. (2013).
    Ras and Rheb signaling in survival and cell death.
    Cancers 5(2): 639–661
    doi: 10.3390/cancers5020639
    Abstract
     
  • Drost J., Nonis D., Eich F., Leske O., Damrath E., Brunt E.R., Lastres-Becker I., Heumann R., Nowock J. and Auburger G. (2013).
    Ataxin-2 modulates the levels of Grb2 and Src but not Ras signaling.
    J. Mol. Neurosci. 51: 68–81
    doi: 10.1007/s12031-012-9949-4
    Abstract
     
  • Nickel K.F., Laux V., Heumann R. and von Degenfeld G. (2013).
    Thrombin has biphasic effects on the nitric oxide-cGMP pathway in endothelial cells and contributes to experimental pulmonary hypertension.
    PLoS ONE 8(6): e63504
    doi: 10.1371/journal.pone.0063504
    Abstract
     
  • Kovtun A., Neumann S., Neumeier M., Urch H., Heumann R., Gepp M., Wallat K., Koeller M., Zimmermann H. and Epple M. (2013).
    Nanoparticle-mediated gene transfer from electrophoretically coated metal surfaces.
    J. Phys. Chem. B 117(6): 1550–1555
    doi: 10.1021/jp303448v
    Abstract
     
  • Damen D. and Heumann R.(2013).
    MeCP2 phosphorylation in the brain: from transcription to behavior.
    Biol. Chem. 394(12): 1595–1605
    doi: 10.1515/hsz-2013-0193
    Abstract
     
  • Bendix I., Weichelt U., Strasser K., Serdar M., Endesfelder S., von Haefen C., Heumann R., Ehrkamp A., Felderhoff-Mueser U. and Sifringer M. (2012).
    Hyperoxia changes the balance of the thioredoxin/peroxiredoxin system in the neonatal rat brain.
    Brain Res. 1484: 68–75
    doi: 10.1016/j.brainres.2012.09.024
    Abstract
     
  • Bendix I., Schulze C., von Haefen C., Gellhaus A., Endesfelder S., Heumann R., Felderhoff-Mueser U. and Sifringer M. (2012).
    Erythropoietin modulates autophagy signaling in the developing rat brain in an in vivo model of oxygen-toxicity.
    Int. J. Mol. Sci. 13(10): 12939–12951
    doi: 10.3390/ijms131012939
    Abstract
     
  • Imielski Y., Schwamborn J.C., Lüningschrör P., Heimann P., Holzberg M., Werner H., Leske O., Püschel A.W., Memet S., Heumann R., Israel A., Kaltschmidt C. and Kaltschmidt B. (2012).
    Regrowing the adult brain: NF-κB controls functional circuit formation and tissue homeostasis in the dentate gyrus.
    PLoS ONE 7(2): e30838
    doi: 10.1371/journal.pone.0030838
    Abstract
     
  • Gasser G., Pinto A., Neumann S., Sosniak A.M., Seitz M., Merz K., Heumann R. and Metzler-Nolte N. (2012).
    Synthesis, characterisation and bioimaging of a fluorescent rhenium-containing PNA bioconjugate.
    Dalton Trans. 41(8): 2304–2313
    doi: 10.1039/C2DT12114J
    Abstract
     
  • Gasser G., Neumann S., Ott I., Seitz M., Heumann R. and Metzler-Nolte N. (2011).
    Preparation and biological evaluation of di-hetero-organometallic-containing PNA bioconjugates.
    Eur. J. Inorg. Chem. 36: 5471–5478
    doi: 10.1002/ejic.201100734
    Abstract
     
  • Lafenetre P., Leske O., Wahle P. and Heumann R. (2011).
    The beneficial effects of physical activity on impaired adult neurogenesis and cognitive performance.
    Front. Neurosci. 5: 51
    doi: 10.3389/fnins.2011.00051
    Abstract
     
  • Manns M., Leske O., Gottfried S., Bichler Z., Lafenetre P., Wahle P. and Heumann R. (2011).
    Role of neuronal Ras activity in adult hippocampal neurogenesis and cognition.
    Front. Neurosci. 5: 18
    doi: 10.3389/fnins.2011.00018
    Abstract
     

Publications 2006-2010

Damen, D., Leske, O., and Heumann, R. (2010). Neuronal activation of ras regulates the adverse phenotype in a mouse  model of Rett Syndrome. International Journal of Developmental Neuroscience 28, 699–700.

Epple, M., Ganesan, K., Heumann, R., Klesing, J., Kovtun, A., Neumann, S., and Sokolova, V. (2010). Application of calcium phosphate nanoparticles in biomedicine. Journal of Materials Chemistry 20, 18–23.

Karassek, S., Berghaus, C., Schwarten, M., Goemans, C.G., Ohse, N., Kock, G., Jockers, K., Neumann, S., Gottfried, S., Herrmann, C., Heumann, R., and Stoll, R. (2010). Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J Biol Chem 285, 33979–33991. Full text pdf

Klesing, J., Chernousova, S., Kovtun, A., Neumann, S., Ruiz, L., Gonzalez-Calbet, J.M., Vallet-Regi, M., Heumann, R., and Epple, M. (2010). An injectable paste of calcium phosphate nanorods, functionalized with  nucleic acids, for cell transfection and gene silencing. Journal of Materials Chemistry 20, 6144–6148.

Kock, G., Dicks, M., Heumann, R., Erdmann, K. S., and Stoll, R. (2010). Sequence-specific H-1, C-13, and N-15 assignment of the extended PDZ3  domain of the protein tyrosine phosphatase basophil-like PTP-BL. Biomolecular NMR Assignments 4, 199–202.

Lafenetre, P., Leske, O., Ma-Hogemeie, Z., Haghikia, A., Bichler, Z., Wahle, P., and Heumann, R. (2010). Exercise can rescue recognition memory impairment in a model with reduced adult hippocampal neurogenesis. Front Behav Neurosci 3, 34.

Leske, O., Bichler, Z., and Heumann, R. (2010). Antidepressant-like features of mice with transgenic activation of Ras  in differentiated neurons. European Neuropsychopharmacology 20, S358-S359.

Manns, M., Bichler, Z., Leske, O., and Heumann, R. (2010). Neuronal Ras activation inhibits adult hippocampal progenitor cell  division and impairs spatial short-term memory. Genes Brain and Behavior 9, 525–536.

Sokolova, V., Neumann, S., Kovtun, A., Chernousova, S., Heumann, R., and Epple, M. (2010). An outer shell of positively charged poly(ethyleneimine) strongly  increases the transfection efficiency of calcium phosphate/DNA  nanoparticles. Journal of Materials Science 45, 4952–4957.

Adiguzel, Y., Hippe, S., Hauswald, H.J., Stoll, R., and Heumann, R. (2009). Phosphorus NMR of model membrane interaction with nitric oxide. FEBS Journal 276, 230.

Kovtun, A., Heumann, R., and Epple, M. (2009). Calcium phosphate nanoparticles for the transfection of cells. Bio-Medical Materials and Engineering 19, 241–247.

Makwana, M., Serchov, T., Hristova, M., Bohatschek, M., Gschwendtner, A., Kalla, R., Liu, Z., Heumann, R., and Raivich, G. (2009). Regulation and function of neuronal GTP-Ras in facial motor nerve regeneration. Journal of Neurochemistry 108, 1453–1463.

Neumann, S., Kovtun, A., Dietzel, I.D., Epple, M., and Heumann, R. (2009). The use of size-defined DNA-functionalized calcium phosphate nanoparticles to minimise intracellular calcium disturbance during transfection. Biomaterials 30, 6794–6802.

Patz, S., Colovic, C., Wawro, S., Lafenetre, P., Leske, O., Heumann, R., Schoenfelder, S., Tomaschewski, J., Raek, A., and Wahle, P. (2009). Interneuronal growth and expression of interneuronal markers in visual cortex of mice with transgenic activation of Ras. Experimental Brain Research 199, 265–278.

Stenzel, N., Fetzer, C.P., Heumann, R., and Erdmann, K.S. (2009). PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells. Journal of Cell Science 122, 3374–3384.

Kovtun A., Heumann R. and Epple M. (2009).
Calcium phosphate nanoparticles for the transfection of cells.
Biomed. Mater. Eng. 19(2–3): 241–247
doi: 10.3233/BME-2009-0586
Abstract
 

Chakrabarty, K., and Heumann, R. (2008). Prospective of Ras signaling in stem cells. Biological Chemistry 389, 791–798.

Ganesan, K., Kovtun, A., Neumann, S., Heumann, R., and Epple, M. (2008). Calcium phosphate nanoparticles: colloidally stabilized and made fluorescent by a phosphate-functionalized porphyrin. Journal of Materials Science 18, 3655–3661.

Mann, S.A., Versmold, B., Marx, R., Stahlhofen, S., Dietzel, I.D., Heumann, R., and Berger, R. (2008). Corticosteroids reverse cytokine-induced block of survival and differentiation of oligodendrocyte progenitor cells from rats. Journal of Neuroinflammation 5, 39.

Chakrabarty K. and Heumann R. (2008).
Prospective of Ras signaling in stem cells.
Biol. Chem. 389(7): 791–798
doi: 10.1515/BC.2008.104
Abstract
 

Berghaus, C., Schwarten, M., Heumann, R., and Stoll, R. (2007). Sequence-specific H-1, C-13, and N-15 backbone assignment of the GTPase rRheb in its GDP-bound form. Biomolecular NMR Assignments 1, 45–47.

Chakrabarty, K., Serchov, T., Mann, S.A., Dietzel, I.D., and Heumann, R. (2007). Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. European Journal of Neuroscience 25, 1971–1981.

Fetzer, C.P., Sauvageau, J., Kock, G., Berghaus, C., Bangert, J.-A., Dicks, M., Heumann, R., Erdmann, K.S., and Stoll, R. (2007). Sequence-specific H-1, C-13, and N-15 backbone assignment of the 28 kDa PDZ2/PDZ3 tandem domain of the protein tyrosine phosphatase PTP-BL. Biomolecular NMR Assignments 1, 151–153.

Gaertner, U., Alpar, A., Heumann, R., and Arendt, T. (2007). Effects of enhanced Ras activity on neuronal morphology in vivo. Journal of Neural Transmission 114, CXXII–CXXIII.

Grote-Westrick, C., and Heumann, R. (2007). Nitric oxide regulates membrane fluidity with implications on cell migration and endocytosis. Journal of Neurochemistry 102, 260.

Sandoval, M., Sandoval, R., Thomas, U., Spilker, C., Smalla, K.-H., Falcon, R., Marengo, J.J., Calderon, R., Saavedra, V., Heumann, R., Bronfman, F., Garner, C.C., Gundelfinger, E.D., and Wyneken, U. (2007). Antagonistic effects of TrkB and p75(NTR) on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes. Journal of Neurochemistry 101, 1672–1684.

Schwarten, M., Berghaus, C., Heumann, R., and Stoll, R. (2007). Sequence-specific H-1, C-13, and N-15 backbone assignment of the activated 21 kDa GTPase rRheb. Biomolecular NMR Assignments 1, 105–108.

Sokolova, V., Kovtun, A., Heumann, R., and Epple, M. (2007). Tracking the pathway of calcium phosphate/DNA nanoparticles during cell transfection by incorporation of red-fluorescing tetramethylrhodamine isothiocyanate-bovine serum albumin into these nanoparticles. Journal of Biological Inorganic Chemistry 12, 174–179.

Sokolova, V., Kovtun, A., Prymak, O., Meyer-Zaika, W., Kubareva, E.A., Romanova, E.A., Oretskaya, T.S., Heumann, R., and Epple, M. (2007). Functionalisation of calcium phosphate nanoparticles by oligonucleotides and their application for gene silencing. Journal of Materials Science 17, 721–727.

Publications 1991-2000

Dietzel I.D., Zhong J. and Heumann R. (1997).
The role of glia in neuroprotection.
In Neuroprotection in CNS Diseases, pages 285–303.
Edited by P. R. Bär and M.F. Beal. Marcel Dekker, Inc. New York.
 

Heumann, R. (1994).
Neurotrophin signalling.
Curr. Opin. Neurobiol. 4(5): 668–679
doi: 10.1016/0959-4388(94)90008-6
Abstract