KONSTANZE F. WINKLHOFER
CELLULAR QUALITY CONTROL AND STRESS RESPONSE PATHWAYS IN NEURODEGENERATION
We are interested in neuroprotective and neurotoxic pathways that are associated with neurodegenerative diseases, such as Parkinson's, Alzheimer's and Huntington's disease. Specifically, we are focusing on the following topics:
- Ubiquitin signaling and stress protection
- Mechanisms to maintain mitochondrial integrity and function
- Interorganellar communication and its role in the cellular stress response
- Cellular quality control mechanisms to promote protein homeostasis
link to PubMed
Bruch et al. (2017). PERK activation mitigates tau pathology in vitro and in vivo. EMBO Mol Med, in press.
Woerner et al. (2016). Cytoplasmic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA. Science, 351(6269):173-176.
Meka et al. (2015). Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. J Clin Invest., 125(5): 1873-1885.
Winklhofer (2014). Parkin and mitochondrial quality control: toward assembling the puzzle. Trends Cell Biol., 24(6): 332-341.
Müller-Rischart et al. (2013). The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell, 49: 908-921.
Klein et al. (2014). Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J, 33(4): 341-55.
Rolland et al. (2013). Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. Proc Natl Acad Sci U S A, 110(32): 2967-2976.