Departments



Molecular Cell Biology

Prof. Dr. Konstanze F. Winklhofer



Systemic Biochemistry


Prof. Dr. Ralf Erdmann



Cellular Biochemistry

Prof. Dr. Joachim Rassow



Biochemistry of Neurodegenerative Diseases

Prof. Dr. Jörg Tatzelt



Microbial Biochemistry

Prof. Dr. Lars Leichert

Latest News

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© Cathrin Schnack

How protein deposits damage neurons

In the brains of patients with neurodegenerative diseases, such as Alzheimer’s or Huntington’s Disease, protein deposits are commonly observed. They are suspected to contribute to neuronal cell death. A team led by Mark Hipp and Ulrich Hartl from the Max Planck Institute of Biochemistry in Martinsried, in collaboration with Konstanze Winklhofer and Jörg Tatzelt from the Ruhr University Bochum, discovered that protein aggregates in the cytoplasm are more harmful than aggregates in the nucleus because they interfere with important transport routes in the cell. The results are reported in “Science”.

Woerner et al. (2015): Cytoplasmic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA, Science, DOI: 10.1126/science.aad2033; published online December 3 2015

http://www.ncbi.nlm.nih.gov

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