Ruhr-Universität Bochum





Originalarbeiten und Übersichts-Artikel (zitiert in Medline / Pubmed / Web of Science)

Berberich J, Dietrich JW, Hoermann R, Müller MA. Mathematical Modeling of the Pituitary-Thyroid Feedback Loop: Role of a TSH-T(3)-Shunt and Sensitivity Analysis. Front Endocrinol (Lausanne). 2018 Mar 21;9:91. doi 10.3389/fendo.2018.00091. PMID 29619006; PMCID PMC5871688.

Larisch R, Midgley JEM, Dietrich JW, Hoermann R. Symptomatic Relief is Related to Serum Free Triiodothyronine Concentrations during Follow-up in Levothyroxine-Treated Patients with Differentiated Thyroid Cancer. Exp Clin Endocrinol Diabetes. 2018 Feb 2. doi 10.1055/s-0043-125064. PMID 29396968.

Hoermann R, Midgley JEM, Larisch R, Dietrich JW. Recent Advances in Thyroid Hormone Regulation: Toward a New Paradigm for Optimal Diagnosis and Treatment. Front Endocrinol (Lausanne). 2017 Dec 22;8:364. doi 10.3389/fendo.2017.00364. PMID 29375474; PMCID PMC5763098.

Hoermann R, Midgley JEM, Larisch R, Dietrich JWC. Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine. PLoS One. 2017 Nov 20;12(11):e0187232. doi 10.1371/journal.pone.0187232. PMID 29155897.

Chatzitomaris A, Hoermann R, Midgley JE, Hering S, Urban A, Dietrich B, Abood A, Klein HH, Dietrich JW. Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming. Front Endocrinol (Lausanne). 2017 Jul 20;8:163. doi: 10.3389/fendo.2017.00163. PMID 28775711; PMCID PMC5517413.

Hoermann R, Midgley JEM, Dietrich JW, Larisch R. Dual control of pituitary thyroid stimulating hormone secretion by thyroxine and triiodothyronine in athyreotic patients. Ther Adv Endocrinol Metab. 2017 Jun;8(6):83-95. doi: 10.1177/2042018817716401. PMID 28794850; PMCID PMC5524252.

Hoermann R, Midgley JE, Larisch R, Dietrich JW (2016). Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease. Eur Thyroid J. 2016 Sep;5(3):171-179. PMID 27843807. doi 10.1159/000447967

Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH., Midgley JE, Hoermann R. Calculated parameters of thyroid homeostasis: Emerging tools for differential diagnosis and clinical research. Frontiers in Endocrinology. 2016; 7:00057. doi: 10.3389/fendo.2016.00057.

Hoermann R, Midgley JE, Larisch R, Dietrich JW. Homeostatic Control of the Thyroid-Pituitary Axis: Perspectives for Diagnosis and Treatment. Front Endocrinol (Lausanne). 2015 Nov 20;6:177. doi: 10.3389/fendo.2015.00177. eCollection 2015. Review. PMID 26635726; PMCID PMC4653296.

Dietrich JW, Midgley JE, Larisch R, Hoermann R. Of rats and men: thyroid homeostasis in rodents and human beings. Lancet Diabetes Endocrinol. 2015 Dec;3(12):932-3. doi: 10.1016/S2213-8587(15)00421-0. PMID 26590684.

Müller P, Dietrich JW, Halbfass P, Abouarab A, Fochler F, Szöllösi A, Nentwich K, Roos M, Krug J, Schade A, Mügge A, Deneke T. Higher incidence of esophageal lesions after ablation of atrial fibrillation related to the use of esophageal temperature probes. Heart Rhythm. 2015 Jul;12(7):1464-9. doi: 10.1016/j.hrthm.2015.04.005. Epub 2015 Apr 3. PMID 25847474.

Frank CU, Braeth S, Dietrich JW, Wanjura D, Loos U. Bridge Technology with TSH Receptor Chimera for Sensitive Direct Detection of TSH Receptor Antibodies Causing Graves' Disease: Analytical and Clinical Evaluation. Horm Metab Res. 2015 Nov;47(12):880-8. doi: 10.1055/s-0035-1554662. Epub 2015 Jun 16. PMID 26079838.

Chatzitomaris A, Scheeler M, Gotzmann M, Köditz R, Schildroth J, Knyhala KM, Nicolas V, Heyer C, Mügge A, Klein HH, Dietrich JW. Second degree AV block and severely impaired contractility in cardiac myxedema: a case report. Thyroid Res. 2015 May 19;8:6. doi: 10.1186/s13044-015-0018-2. eCollection 2015. PMID 26000037; PubMed Central PMCID: PMC4440534.

Midgley JE, Larisch R, Dietrich JW, Hoermann R. Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency. Endocr Connect. 2015 Dec;4(4):196-205. doi: 10.1530/EC-150056. PMID 26265111. PMCID PMC4557078

Dietrich JW, Müller P, Schiedat F, Schlömicher M, Strauch J, Chatzitomaris A, Klein HH, Mügge A, Köhrle J, Rijntjes E, Lehmphul I. Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling. Eur Thyroid J. 2015 Jun;4(2):129-37. doi: 10.1159/000381543. Epub 2015 May 23. PMID 26279999; PMCID PMC4521060.

Hoermann R, Midgley JE, Larisch R, Dietrich JW. Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Horm Metab Res. 2015; 47(9):674-80. PMID 25750078.

Hoermann R, Midgley JE, Giacobino A, Eckl WA, Wahl HG, Dietrich JW, Larisch R. Homeostatic Equilibria Between Free Thyroid Hormones and Pituitary Thyrotropin Are Modulated By Various Influences Including Age, Body Mass Index and Treatment. Clin Endocrinol (Oxf). 2014 Dec;81(6):907-15. doi: 10.1111/cen.12527. PMID 24953754.

Goede, S.L., Leow, M.K., Smit, J.W., Klein, H.H. & Dietrich, J.W. (2014) Hypothalamus-Pituitary-Thyroid Feedback Control: Implications of Mathematical Modeling and Consequences for Thyrotropin (TSH) and Free Thyroxine (FT4) Reference Ranges. Bull Math Biol. PMID 24789568.

Knoop, U., Dietrich, J.W., Heyer, C.M., Koch, A. & Knoop, H. (2014) "Still crazy after all these years" - Tuberculosis as an Old Disease with Diverse Facets in a Thirty-five-year-old Male Patient. Pneumologie 68, 206-207. PMID 24301553.

Goede SL, Leow MK, Smit JW, Dietrich JW (2014): A novel minimal mathematical model of the hypothalamus-pituitary-thyroid axis validated for individualized clinical applications. Mathematical biosciences 2014. 249:1-7. PMID 24480737

Dietrich JW, Leow MK, Goede SL, Midgley JE, Landgrafe G, Hoermann R (2013). Do thyroid-stimulating hormone, body weight, or body mass index serve as adequate markers to guide levothyroxine dose titration? J Am Coll Surg. 2013 Oct;217(4):752-3. doi: 10.1016/j.jamcollsurg.2013.06.008. PMID 24054412.

Müller P, Deneke T, Schiedat F, Bösche L, Strauch J, Dietrich JW, Vogt M, Tannapfel A, Stiegler H, Mügge A, Ewers A (2013). Increased Preoperative Serum Apoptosis Marker Fas Ligand Correlates With Histopathology and New-Onset of Atrial Fibrillation in Patients After Cardiac Surgery. J Cardiovasc Electrophysiol. 2013 May 23. doi: 10.1111/jce.12191. PMID 23790081.

Dietrich JW, Ehren M, Ruff-Dietrich S, Klein HH (2013). 43-jährige Patientin mit Diabetes mellitus und postoperativem Kreislaufkollaps [43-year-old woman with diabetes and postoperative circulatory collapse]. Dtsch Med Wochenschr. 2013 May;138(18):945-6. doi: 10.1055/s-0032-1332869. Epub 2013 Apr 23. German. PMID 23613373.

Ehren M, Dietrich JW (2013). Patientin mit Diabetes mellitus Typ 1 und akut aufgetretenen Ödemen [Woman with type 1 diabetes mellitus and rapidly progressive edema]. Dtsch Med Wochenschr. 2013 May;138(18):940-4. doi: 10.1055/s-0033-1343162. Epub 2013 Apr 23. PMID 23613372.

Midgley, J. E. M., R. Hoermann, R. Larisch, J. W. Dietrich (2013). Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model. Journal of Clinical Pathology 2013 Apr;66(4):335-42. PMID 23423518, doi:10.1136/jclinpath-2012-201213

Knoop H, Knoop U, Behr J, Heyer CM, Kuert S, Roggenland D, Suermann M, Dietrich JW (2013). Syndrome of Inadequate Antidiuretic Hormone Secretion in Pulmonary Tuberculosis - a Therapeutic Challenge. Pneumologie. 2013 Apr;67(4):219-22. PubMed PMID 23420227. doi:10.1055/s-0032-1326101

Müller P, Hars C, Schiedat F, Bösche LI, Gotzmann M, Strauch J, Dietrich JW, Vogt M, Tannapfel A, Deneke T, Mügge A, Ewers A (2013). Correlation Between Total Atrial Conduction Time Estimated via Tissue Doppler Imaging (PA-TDI Interval), Structural Atrial Remodeling and New-Onset of Atrial Fibrillation After CardiacSurgery. J Cardiovasc Electrophysiol. 2013 Jun;24(6):626-31. doi: 10.1111/jce.12084. PMID 23398627. doi:10.1111/jce.12084.

Hoermann, R., J. E. M. Midgley, R. Larisch, J. W. Dietrich (2013). Is Pituitary Thyrotropin an Adequate Measure Of Thyroid Hormone-Controlled Homeostasis During Thyroxine Treatment?. European Journal of Endocrinology 168(2):271-80. PMID 23184912, doi:10.1530/EJE-12-0819.

Dietrich, J. W., G. Landgrafe, E. H. Fotiadou (2012). TSH and thyrotropic agonists: Key actors in thyroid homeostasis. Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. PMID 23365787, doi:10.1155/2012/351864.

Dietrich, J. W. (2012). Thyreotoxische Krise [Thyroid Storm.]. Med Klin Intensivmed Notfmed 107: 448-53. [PMID 22878518]

Giebelstein, J., G. Poschmann, K. Hojlund, W. Schechinger, J. W. Dietrich, K. Levin, H. Beck-Nielsen, K. Podwojski, K. Stuhler, H. E. Meyer und H. H. Klein (2012). The proteomic signature of insulin-resistant human skeletal muscle reveals increased glycolytic and decreased mitochondrial enzymes. Diabetologia 55:1114-27. Erratum in: Diabetologia. 2012 Jul;55(7):2083. [PMID 22282162]

Boehm, B. O., S. Rosinger, D. Belyi, and J. W. Dietrich (2011). The parathyroid as a target for radiation damage. N Engl J Med 365 (7):676-8. [PMID 21848480]

Ueberberg S., T. Deutschbein, H. H. Klein, J. W. Dietrich, S. Akinturk, N. Prochnow, R. Schirrmacher, S. Schneider (2011) Protection from diabetes development by single-chain antibody-mediated delivery of a NF-{kappa}{kappa}B inhibitor specifically to {beta}{beta}-cells in vivo. Am J Physiol Endocrinol Metab 301 (1):E83-90. [PMID 21521716]

Meier JJ, Ueberberg S, Korbas S, Schneider S. Diminished glucagon suppression after ?-cell reduction is due to impaired ?-cell function rather than an expansion of Beta-cell mass. Am J Physiol Endocrinol Metab. 2011 Apr;300(4):E717-23.Epub 2011 Feb 1. [PMID 21285404].

Ueberberg, S., D. Ziegler, W. Schechinger, J. W. Dietrich, S. Akinturk, H. H. Klein, and S. Schneider (2010). In vitro phage display in a rat beta cell line: a simple approach for the generation of a single-chain antibody targeting a novel beta cell-specific epitope. Diabetologia 53(7): 1384-94. [PMID 20369222]

Ueberberg S, Schneider S. Phage library-screening: a powerful approach for generation of targeting-agents specific for normal pancreatic islet-cells and islet-cell carcinoma in vivo. Regul Pept. 2010 Feb 25;160(1-3):1-8. Epub 2009 Dec 1. [PMID 19958795]

Germing A, Gotzmann M, Rauße R, Brodherr T, Holt S, Lindstaedt M, Dietrich J, Ranft U, Krämer U, Mügge A (2010). Normal values for longitudinal function of the right ventricle in healthy women >70 years of age. Eur J Echocardiogr. 11(8): 725-8. [PMID 20418271]

Boehm, B. O., M. Steinert, J. W. Dietrich, R. U. Peter, D. Belyi, G. Wagemaker, S. Rosinger, T. M. Fliedner, M. Weiss (2009). “Thyroid examination in highly radiation-exposed workers after the Chernobyl accident.” Eur J Endocrinol 160 (4): 625-30. [PMID 19147598]

Ueberberg, S., J. J. Meier, C. Waengler, W. Schechinger, J. W. Dietrich, A. Tannapfel, I. Schmitz, R. Schirrmacher, M. Koller, H. H. Klein, S- Schneider (2009). “Generation of novel single-chain antibodies by phage-display technology to direct imaging agents highly selective to pancreatic {beta}- or {alpha}-cells in vivo.” Diabetes 58(10): 2324-2334. [PMID 19592622]

Chen KC, Wu CH, Chang CY, Lu WC, Tseng Q, Prijovich ZM, Schechinger W, Liaw YC, Leu YL, Roffler SR. Directed evolution of a lysosomal enzyme with enhanced activity at neutral pH by mammalian cell-surface display. Chem Biol. 2008 Dec 22;15(12):1277-86. [PMID 19101472]

Orcy RB, Schroeder S, Martins-Costa SH, Ramos JG, Schechinger W, Klein H, Brum IS, von Eye Corleta H, Capp E. Signalization of Akt/PKB in the placenta, skeletal muscle and adipose tissue of preeclampsia patients. Gynecol Obstet Invest. 2008;66(4):231-6. Epub 2008 Jul 22. [PMID 18645256]

Dietrich, J. W., K. Brisseau und B. O. Boehm (2008). "Resorption, Transport und Bioverfügbarkeit von Schilddrüsenhormonen." Deutsche Medizinische Wochenschrift 133 (31/21): 1644-8. [PMID 18651367]

Dietrich, J. W., A. Stachon, B. Antic, H. H. Klein und S. Hering (2008). "The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome." BMC Endocrine Disorders 8 (13). [PMID 18851740]

Schneider S, Ueberberg S, Korobeynikov A, Schechinger W, Schwanstecher C, Schwanstecher M, Klein HH, Schirrmacher E. Synthesis and evaluation of a glibenclamide glucose-conjugate: a potential new lead compound for substituted glibenclamide derivatives as islet imaging agents. Regul Pept. 2007 Mar 1;139(1-3):122-7. Epub 2007 Jan 10. [PMID 17222470]

Dietrich, J. W. und B. O. Boehm (2006). "Thyroxine in Goiter, H. pylori Infection, and Gastritis." New Engl J Med 355 (11): 1177. [PMID 16971728]

Dietrich, J. W., K. Gieselbrecht, R. W. Holl und B. O. Boehm (2006). "Absorption Kinetics of Levothyroxine Is Not Altered by Proton-pump Inhibitor Therapy." Hormone and Metabolic Research 38 (1): 57-59. [PMID 16477543]

Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2004). "Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis." Cybernetics and Systems 35 (4): 315-31. [DOI 10.1080/01969720490443354]

Gärtner, R., B. Gasnier, J. Dietrich, B. Krebs und M. Angstwurm (2002). "Selenium Supplementation in Patients with Autoimmune Thyroiditis Decreases Thyroid Peroxidase Antibodies Concentrations." J Clin Endocrinol Metab 87 (4): 1687-91. [PMID 11932302]

Houdali B, Nguyen V, Ammon HP, Haap M, Schechinger W, Machicao F, Rett K, Häring HU, Schleicher ED. Prolonged glucose infusion into conscious rats inhibits early steps in insulin signalling and induces translocation of GLUT4 and protein kinase C in skeletal muscle. Diabetologia. 2002 Mar;45(3):356-68. [PMID 11914741]

Fischer, M. R., J. W. Dietrich, M. Maleck, U. D. Stade und F. Eitel (2000). "Rechnerunterstützte Instruktion in der Medizin: Eine multizentrische Evaluationsstudie in sieben deutschsprachigen Mediotheken." Gesundheitswesen 62 (Mai 2000): 289-94. [PMID 10893877]



Dietrich, J. W., R. Köditz, A. Ackermann, A. Jeyabalan, Y. Kunanayagam, T. Tharmalingam A. Urban, B. Antic, A. Stachon, H. H. Klein, S. Hering (2008). "Rückbildung eines Low-T3-Syndroms nach Beginn einer Hypothermiebehandlung." Intensivmedizin und Notfallmedizin 45 (Supplement 1): I/41.

Dietrich, J. W., A. Ackermann, A. Jeyabalan, Y. Kunanayagam, T. Tharmalingam, A. Urban, A. Stachon, H. H. Klein, S. Hering (2008). "Schilddrüsenautoantikörper korrelieren nicht mit Häufigkeit oder Prognose eines Non-Thyroidal-Illness-Syndroms." Medizinische Klinik 103 (Supplement 1): 109.

Dietrich, J. W., A. Ackermann, A. Jeyabalan, Y. Kunanayagam, T. Tharmalingam, A. Urban, A. Stachon, H. H. Klein, S. Hering (2008). "Iodothyronine antibodies are not correlated with prevalence or prognosis of non-thyroidal illness syndrome." Endocrine Abstracts 16: P821.

Dietrich, J. W., A. Ackermann, A. Jeyabalan, Y. Kunanayagam, T. Tharmalingam A. Urban, B. Antic, R. Köditz, A. Stachon, H. H. Klein, S. Hering (2008). "Antikörper gegen Jodothyronine korrelieren weder mit Häufigkeit noch Prognose eines Non-thyroidal-illness-Syndroms." Intensivmedizin und Notfallmedizin 45 (Supplement 1): I/41.


Bücher und Buchbeiträge

Dietrich JW, Rigas N, Fotiadou EH, Landgrafe-Mende G, Klein HH, Leow MK, Goede SL. Die Rekonstruktion
des Sollwerts der Schilddrüsenhomöostase – ein Weg zur personalisierten Therapie der Hypothyreose
. In:
Führer D, editor. Schilddrüse 2015. Berlin: Lehmanns (2016). p. 107–16.

B. Gallwitz, H.-G. Joost, H. Klein, S. Matthaei (2011). Insulinotrope orale Antidiabetika und inkretinbasierte Therapieformen. In: Diabetologie in Klinik und Praxis: Das Referenzwerk für die alltägliche Praxis. H.-U. Häring, B. Gallwitz, D. Müller-Wieland, K.-H. Usadel, H. Mehnert (Hrsg.). Stuttgart, Georg-Thieme-Verlag: 167-80

M. Ehren, A. Burchard, D. Müller-Wieland, H. Klein (2011). Operationen. In: Diabetologie in Klinik und Praxis: Das Referenzwerk für die alltägliche Praxis. H.-U. Häring, B. Gallwitz, D. Müller-Wieland, K.-H. Usadel, H. Mehnert (Hrsg.). Stuttgart, Georg-Thieme-Verlag: 326-30

Dietrich, J. W. und B. O. Boehm (2006). Equilibrium behaviour of feedback-coupled physiological saturation kinetics. In: Cybernetics and Systems 2006. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies. 1: 269-74.

Dietrich, J. W. und B. O. Boehm (2004). Antagonistic Redundancy - A Theory of Error-Correcting Information Transfer in Organisms. In: Cybernetics and Systems 2004. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies. 1: 225-30.

Dietrich, J. W. (2002). Der Hypophysen-Schilddrüsen-Regelkreis. Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin, Logos-Verlag.

Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2002). Fractal Properties of the Thyrotropic Feedback Control: Implications of a Nonlinear Model Compared with Empirical Data. In: Cybernetics and Systems 2002. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies: 329-34.


                  Universitätsklinikum Bergmannsheil