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Selected Publications of the SPINA Group:

Papers and reviews (cited in Medline / Pubmed)

Dietrich, J. W., A. Stachon, B. Antic, H. H. Klein und S. Hering (2008). "The AQUA-FONTIS Study: Protocol of a multidisciplinary, cross-sectional and prospective longitudinal study for developing standardized diagnostics and classification of non-thyroidal illness syndrome." BMC Endocrine Disorders 8 (13). [PMID 18851740]

Dietrich, J. W. (2012). Thyreotoxische Krise [Thyroid Storm.]. Med Klin Intensivmed Notfmed 107: 448-53. [PMID 22878518]

Dietrich, J. W., G. Landgrafe, E. H. Fotiadou (2012). TSH and thyrotropic agonists: Key actors in thyroid homeostasis. Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. PMID 23365787, doi:10.1155/2012/351864.

Hoermann, R., J. E. M. Midgley, R. Larisch, J. W. Dietrich (2013). Is Pituitary Thyrotropin an Adequate Measure Of Thyroid Hormone-Controlled Homeostasis During Thyroxine Treatment?. European Journal of Endocrinology 168(2):271-80. PMID 23184912, doi:10.1530/EJE-12-0819.

Midgley, J. E. M., R. Hoermann, R. Larisch, J. W. Dietrich (2013). Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model. Journal of Clinical Pathology 66(4):335-42. PMID 23423518, doi:10.1136/jclinpath-2012-201213

Dietrich JW, Leow MK, Goede SL, Midgley JE, Landgrafe G, Hoermann R (2013). Do thyroid-stimulating hormone, body weight, or body mass index serve as adequate markers to guide levothyroxine dose titration? J Am Coll Surg. 2013 Oct;217(4):752-3. doi: 10.1016/j.jamcollsurg.2013.06.008. PMID 24054412.

Hoermann R, Midgley JE, Giacobino A, Eckl WA, Wahl HG, Dietrich JW, Larisch R. Homeostatic Equilibria Between Free Thyroid Hormones and Pituitary Thyrotropin Are Modulated By Various Influences Including Age, Body Mass Index and Treatment. Clin Endocrinol (Oxf). 2014 Dec;81(6):907-15. doi: 10.1111/cen.12527. PMID 24953754.

Hoermann R, Midgley JE, Larisch R, Dietrich JW. Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Horm Metab Res. 2015; 47(9):674-80. PMID 25750078.

Dietrich JW, Müller P, Schiedat F, Schlömicher M, Strauch J, Chatzitomaris A, Klein HH, Mügge A, Köhrle J, Rijntjes E, Lehmphul I. Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling. Eur Thyroid J. 2015 Jun;4(2):129-37. doi: 10.1159/000381543. Epub 2015 May 23. PMID 26279999; PMCID PMC4521060.

Midgley JE, Larisch R, Dietrich JW, Hoermann R. Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency. Endocr Connect. 2015 Dec;4(4):196-205. doi: 10.1530/EC-150056. PMID 26265111. PMCID PMC4557078

Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH., Midgley JE, Hoermann R. Calculated parameters of thyroid homeostasis: Emerging tools for differential diagnosis and clinical research. Frontiers in Endocrinology. 2016; 7:00057. doi: 10.3389/fendo.2016.00057.

Hoermann R, Midgley JE, Larisch R, Dietrich JW (2016). Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease. Eur Thyroid J. 2016 Sep;5(3):171-179. PMID 27843807. doi 10.1159/000447967

Hoermann R, Midgley JEM, Dietrich JW, Larisch R. Dual control of pituitary thyroid stimulating hormone secretion by thyroxine and triiodothyronine in athyreotic patients. Ther Adv Endocrinol Metab. 2017 Jun;8(6):83-95. doi: 10.1177/2042018817716401. PMID 28794850; PMCID PMC5524252.

Chatzitomaris A, Hoermann R, Midgley JE, Hering S, Urban A, Dietrich B, Abood A, Klein HH, Dietrich JW. Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming. Front Endocrinol (Lausanne). 2017 Jul 20;8:163. doi: 10.3389/fendo.2017.00163. PMID 28775711; PMCID PMC5517413.

Hoermann R, Midgley JEM, Larisch R, Dietrich JWC. Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine. PLoS One. 2017 Nov 20;12(11):e0187232. doi 10.1371/journal.pone.0187232. PMID 29155897.

Hoermann R, Midgley JEM, Larisch R, Dietrich JW. Recent Advances in Thyroid Hormone Regulation: Toward a New Paradigm for Optimal Diagnosis and Treatment. Front Endocrinol (Lausanne). 2017 Dec 22;8:364. doi 10.3389/fendo.2017.00364. PMID 29375474; PMCID PMC5763098.

Larisch R, Midgley JEM, Dietrich JW, Hoermann R. Symptomatic Relief is Related to Serum Free Triiodothyronine Concentrations during Follow-up in Levothyroxine-Treated Patients with Differentiated Thyroid Cancer. Exp Clin Endocrinol Diabetes. 2018 Feb 2. doi 10.1055/s-0043-125064. PMID 29396968.

Berberich J, Dietrich JW, Hoermann R, Müller MA. Mathematical Modeling of the Pituitary-Thyroid Feedback Loop: Role of a TSH-T(3)-Shunt and Sensitivity Analysis. Front Endocrinol (Lausanne). 2018 Mar 21;9:91. doi 10.3389/fendo.2018.00091. PMID 29619006; PMCID PMC5871688.


Papers (cited in BIOSIS Previews and Zentralblatt MATH)

Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2004). "Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis." Cybernetics and Systems 35 (4): 315-31. [DOI 10.1080/01969720490443354]


Papers (others)

Dietrich, J. W. (2000). "Signal Storage in Metabolic Pathways: The ASIA Element." kybernetiknet 1 (3, 2000): 1-9.



Dietrich, J. W., U. Mitzdorf, R. Weitkunat und C. R. Pickardt (1997). "The pituitary-thyroid feedback control: stability and oscillations in a new nonlinear model." Journal of Endocrinological Investigation 20 (Suppl. to no. 5): 100.

Dietrich, J. W., M. R. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A novel systems theoretic approach to determine the secretion capacity of the thyroid gland." European Journal of Internal Medicine 10 (Suppl. 1) (May 1999): S34.

Dietrich, J. W., R. Köditz, A. Ackermann, A. Jeyabalan, Y. Kunanayagam, T. Tharmalingam A. Urban, B. Antic, A. Stachon, H. H. Klein, S. Hering (2008). "Rückbildung eines Low-T3-Syndroms nach Beginn einer Hypothermiebehandlung." Intensivmedizin und Notfallmedizin 45 (Supplement 1): I/41.


Books and book sections

Dietrich, J. W. (2002). Der Hypophysen-Schilddrüsen-Regelkreis. Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin, Logos-Verlag.

Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2002). Fractal Properties of the Thyrotropic Feedback Control: Implications of a Nonlinear Model Compared with Empirical Data. In: Cybernetics and Systems 2002. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies: 329-34.

Dietrich, J. W. und B. O. Boehm (2004). Antagonistic Redundancy - A Theory of Error-Correcting Information Transfer in Organisms. In: Cybernetics and Systems 2004. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies. 1: 225-30.

Dietrich, J. W. und B. O. Boehm (2006). Equilibrium behaviour of feedback-coupled physiological saturation kinetics. In: Cybernetics and Systems 2006. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies. 1: 269-74.

Selected Publications (third party):

Papers (cited in Medline / Pubmed)

Rosolowska-Huszcz D, Kozlowska L, Rydzewski A (2005). Influence of low protein diet on nonthyroidal illness syndrome in chronic renal failure. Endocrine. 27(3):283-8. [PMID 16230785]

Liu S, Ren J, Zhao Y, Han G, Hong Z, Yan D, Chen J, Gu G, Wang G, Wang X, Fan C, Li J. Nonthyroidal Illness Syndrome: Is it Far Away From Crohn's Disease? J Clin Gastroenterol. 2012 Aug 7. [Epub ahead of print] [PMID 22874844]

Han G, Ren J, Liu S, Gu G, Ren H, Yan D, Chen J, Wang G, Zhou B, Wu X, Yuan Y, Li J. Nonthyroidal illness syndrome in enterocutaneous fistulas. Am J Surg. 2013 Sep;206(3):386-92. doi: 10.1016/j.amjsurg.2012.12.011. Epub 2013 Jun 27. PMID 23809674.

Fan S, Ni X, Wang J, Zhang Y, Tao S, Chen M, Li Y, Li J. Low Triiodothyronine Syndrome in Patients With Radiation Enteritis: Risk Factors and Clinical Outcomes an Observational Study. Medicine (Baltimore). 2016 Feb;95(6):e2640. doi 10.1097/MD.0000000000002640. PMID 26871787.

Wang X, Liu H, Chen J, Huang Y, Li L, Rampersad S, Qu S. Metabolic Characteristics in Obese Patients Complicated by Mild Thyroid Hormone Deficiency. Horm Metab Res. 2016 May;48(5):331-7. doi: 10.1055/s-0042-105150. PMID 27101096.

Gürdal A, Eroğlu H, Helvaci F, Sümerkan MÇ, Kasali K, Çetin Ş, Aksan G, Kiliçkesmez K. Evaluation of Tp-e interval, Tp-e/QT ratio and Tp-e/QTc ratio in patients with subclinical hypothyroidism. Ther Adv Endocrinol Metab. 2017 Mar;8(3):25-32. doi 10.1177/2042018816684423. PMID 28377800.

Chan YX, Knuiman MW, Divitini ML, Brown SJ, Walsh J, Yeap BB. Lower TSH and higher free thyroxine predict incidence of prostate but not breast, colorectal or lung cancer. Eur J Endocrinol. 2017 Oct;177(4):297-308. doi 10.1530/EJE-17-0197. PMID 28684452.

Krysiak R, Szkróbka W, Okopień B. Sex-Dependent Effect of Metformin on Serum Prolactin Levels In Hyperprolactinemic Patients With Type 2 Diabetes: A Pilot Study. Exp Clin Endocrinol Diabetes. 2017 Nov 23. doi 10.1055/s-0043-122224. PMID 29169197.

Ruiz-Núñez B, Tarasse R, Vogelaar EF, Janneke Dijck-Brouwer DA, Muskiet FAJ. Higher Prevalence of "Low T3 Syndrome" in Patients With Chronic Fatigue Syndrome: A Case-Control Study. Front Endocrinol (Lausanne). 2018 Mar 20;9:97. doi 10.3389/fendo.2018.00097. PMID 29615976; PMCID PMC5869352.

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