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Protein Research Department

The Protein Research Department (PRD) bundles cutting-edge research for a better understanding of cellular protein networks and forms around the DFG Collaborative Research Centers SFB 642 (spokesman: Klaus Gerwert) and SFB 480 (spokesman: Ulrich Kück). For the 19 projects, its Principle Investigators (PIs) are recruited from the faculties of Biology and Biotechnology, Chemistry and Biochemistry as well as Medicine and work within three areas: Sensory Biology (A), Platform Technologies in Protein Research (B), and Translation into Application (C). Under this umbrella, topics ranging from protein structure and mechanism, macromolecular assemblies, and functions of membrane-protein complexes up to cellular behaviour are studied from a molecular perspective using state of the art methods in structural biology, biophysics, biochemistry, and cell biology.
The PRD primarily targets at bridging the current gap between molecular and systemic approaches in protein research in order to achieve a molecular understanding of the cellular processes. Quantitative understanding of such complex and controlled biological processes at the cellular level requires a profound insight into the relationship between various genetically programmed and dynamically regulated networks. The PRD will focus on processes originating at, or involving biological membranes, exemplified by studies on sensory transduction originating at G-Protein Coupled receptors (GPCRs) and pathways involving GTP-binding proteins of the Ras superfamily. Since defects in the addressed interactions account for a variety of serious diseases, the acquired understanding at the atomic level should eventually result in the development of innovative biotechnology applications with long-term benefits for public health, e.g. tailored drugs for molecular therapy or the identification of biomarkers.

Illustration of the different levels, on which biological processes are being studied within the PRD. The goal of this Research Department centers on bridging the gap between a detailled understanding of structure and function of single proteins in vitro as well as the rather qualitative understanding of protein interactions in protein networks in vivo, following this task both in „bottom-up“ and in „top-down“ approaches. This procedure allows firstly the identification of biomarkers for an early recognition of diseases, and secondly a directed intervention into disease-causing processes within molecular therapies.



German-Chinese Mini-Symposium
On Monday, Sept. 28th 2009, the PRD hosted a German-Chinese mini-symposium titled "Current Changes in Computational Biology" in the Chair of Biophysics. Further information can be downloaded here.


Prof. Dr. Gerwert --- Instituts-Direktor in Shanghai
The speaker of the PRD, Prof. Dr. Klaus Gerwert, has been appointed „Fellow of the Max-Planck Society“ and Director at the Max-Planck Partner Institute for Computational Biology in Shanghai.
Sorry, no English version of the press release available.


Prof. Dr. Helmut E. Meyer -- ParkCHIP
Together with colleagues from the joint Bochum-Dortmund project "ParkCHIP", PRD member Prof. Dr. Helmut E. Meyer (MPC) has raised 3.3 million € within the contest "Hightech.NRW"; these funds will be used for the development of minimal-invasive testing procedures for parkisonism.
Sorry, no English version of the press release available.


PRD Flyer
Information about the research topics within the PRD.

Flyer RDs
Information about the Research Departments of the Ruhr-Universität Bochum.

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Last update: 16.12.2009 | For any questions please contact