Terahertz (THz) Spectroscopy

THz dance of water

In the liquid phase, water molecules are connected to one another via hydrogen bonds. Fluctuations in the water network occur on the sub-ps and ps timescale. THz absorption measurements (1 THz = 1012 Hz = 1 ps-1) "see" these dynamic reorientations of dipole moments. This makes THz spectroscopy a sensitive tool to probe solute-induced changes in the collective water network motions.

THz spectroscopy of solvation of biomolecules

The influence of water on the dynamics of biomolecules is an important research topic. THz spectroscopy can detect even small solute-induced changes of the collective water network dynamics at the biomolecule-water interface.

Thz Tanz German

THz spectroscopy of solvation of biomolecules

The influence of water on the dynamics of biomolecules is an important research topic. THz spectroscopy can detect even small solute-induced changes of the collective water network dynamics at the biomolecule-water interface.

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Kinetic THz absorption (KITA)

KITA has been developed in our group as a tool to probe changes in solvation dynamics upon biological function, e.g. protein folding, enzyme activity, water dynamics, calorimetry. With the help of the stopped flow and temperature jump technique, real-time changes in the protein-water network were detected during protein folding using terahertz absorption spectroscopy.

Kita

 Most relevant publications

Pfeilicon"Ion Hydration and Ion Pairing as Probed by THz Spectroscopy", G. Schwaab, F. Sebastiani, M. Havenith, Angew. Chem. Intl. Ed.  57, 2 (2018).

"Water dynamics from THz spectroscopy reveal the locus of a liquid-liquid binodal limit in aqueous CaCO3 solutions", F. Sebastiani, S.L.P. Wolf, B. Born, T.Q. Luong, H. Colfen, D. Gebauer, M. Havenith, Angew. Chem. Intl. Ed. 56, 490 (2017).

"Mapping Hydration Water around Alcohol Chains by THz Calorimetry", F. Böhm, G. Schwaab, M. Havenith, Angew. Chem. Intl. Ed. 56, 9981 (2017).

"Hydrophobic collapse induces changes in the collective protein and hydration low frequency modes", T.Q. Luong, Y. Xu, E. Bründermann, D.M. Leitner, M. Havenith, Chem. Phys. Lett. 651, 1 (2016).

Pfeilicon"Understanding THz spectra of aqueous solutions: Glycine in light and heavy water", J. Sun, G. Niehues, H. Forbert, D. Decka, G. Schwaab, D. Marx, M. Havenith, J. Am. Chem. Soc. 136, 5031 (2014).

"Rattling in the cage: Ions as probes of sub-ps water network dynamics", D.A. Schmidt, Ö. Birer, S. Funkner, B. Born, R. Gnanasekaran, G. Schwaab, D.M. Leitner, M. Havenith, J. Am. Chem. Soc. 131, 18512 (2009).

"Real-time detection of protein-water dynamics upon protein folding by Terahertz absorption", B. Born, M. Havenith, M. Gruebele, Angew. Chem. Intl. Ed. 47, 6486 (2008).
 
"An extended dynamical solvation shell around proteins", S. Ebbinghaus, S.J. Kim, M. Heyden, X. Yu, U. Heugen, M. Gruebele, D.M. Leitner, M. Havenith, PNAS 104, 20749 (2007).

"Solute-induced retardation of water dynamics probed directly by THz spectroscopy", U. Heugen, G.Schwaab, E. Bründermann, M. Heyden, X. Yu, D.M Leitner, M. Havenith, PNAS 103, 12301 (2006).