Dr. rer. nat. Melanie Lenz

Dipl. Biol.

Melanie Lenz


Main research

Main topic of my research is neuronal plasticity induced by perceptual learning and pain. As a member of the collaborative research center 874 (projects A1, A5 and B4) I study training induced changes in cortical excitability and reorganisation in the visual and somatosensory cortex. During my PhD thesis I investigated changes in patients with complex regional pain syndrome.

Methods and Research Interests
• Perceptual learning
• Cortical excitability
• Pain
• Functional magnetic resonance imaging fMRI
• Evoked potentials EP


Curriculum vitae

since 05/2016
PostDoc in the Neuroimaging Research Group Neuroplasticity/Learning at the University Clinic Bergmannsheil

05/2016
Promotion (Dr. rer. nat.) at the Faculty of Psychology, Thesis: "Central and peripheral abnormalities in patients with complex regional pain syndrome"

09/2013 - 09/2014
parental leave

07/2007 - 05/2016
Research fellow in the Neuroimaging Research Group Neuroplasticity/Learning at the University Clinic Bergmannsheil

03/2007
Diploma in Biology (Ruhr University Bochum)


Publications

Dinse HR, Kattenstroth JC, Lenz M, Tegenthoff M, Wolf OT. The stress hormone cortisol blocks perceptual learning in humans. Psychoneuroendocrinology 2016; 77:63-67 [Epub ahead of print]

Enax-Krumova EK, Lenz M, Frettlöh J, Höffken O, Reinersmann A, Schwarzer A, Westermann A, Tegenthoff M, Maier C. Changes of the Sensory Abnormalities and Cortical Excitability in Patients with Complex Regional Pain Syndrome of the Upper Extremity After 6 Months of Multimodal Treatment. Pain Med 2016; pii: pnw147 [Epub ahead of print]

Rehmann R, Sczesny-Kaiser M, Lenz M, Gucia T, Schliesing A, Schwenkreis P, Tegenthoff M, Höffken O. Polarity-Specific Cortical Effects of Transcranial Direct Current Stimulation in Primary Somatosensory Cortex of Healthy Humans. Front Hum Neurosci 2016; 10:208

Stude P, Lenz M, Höffken O, Tegenthoff M, Dinse H. A single dose of lorazepam reduces paired-pulse suppression of median nerve evoked somatosensory evoked potentials. Eur J Neurosci 2016; 43:1156-1160

Heba S, Puts NA, Kalisch T, Glaubitz B, Haag LM, Lenz M, Dinse HR, Edden RA, Tegenthoff M, Schmidt-Wilcke T. Local GABA Concentration Predicts Perceptual Improvements After Repetitive Sensory Stimulation in Humans. Cereb Cortex 2015; 26:1295-1301

Schlaffke L, Golisch A, Haag LM, Lenz M, Heba S, Lissek S, Schmidt-Wilcke T, Eysel UT, Tegenthoff M. The brain's dress code: How The Dress allows to decode the neuronal pathway of an optical illusion. Cortex 2015; 73:271-275

Haag LM, Heba S, Lenz M, Glaubitz B, Höffken O, Kalisch T, Puts NA, Edden RA, Tegenthoff M, Dinse H, Schmidt-Wilcke T. Resting BOLD fluctuations in the primary somatosensory cortex correlate with tactile acuity. Cortex 2015; 64:20-28

Stude P, Enax-Krumova EK, Lenz M, Lissek S, Nicolas V, Peters S, Westermann A, Tegenthoff M, Maier C. Local anesthetic sympathectomy restores fMRI cortical maps in CRPS I after upper extremity stellate blockade: a prospective case study. Pain Physician 2014; 17:E637-644

Schlaffke L, Lissek S, Lenz M, Juckel G, Schultz T, Tegenthoff M, Schmidt-Wilcke T, Brüne M. Shared and nonshared neural networks of cognitive and affective theory-of-mind: a neuroimaging study using cartoon picture stories. Hum Brain Mapp 2015; 36:29-39

Lissek S, Vallana GS, Schlaffke L, Lenz M, Dinse HR, Tegenthoff M. Opposing effects of dopamine antagonism in a motor sequence task-tiapride increases cortical excitability and impairs motor learning. Front Behav Neurosci 2014; 8:201

Pleger B, Draganski B, Schwenkreis P, Lenz M, Nicolas V, Maier C, Tegenthoff M. Complex regional pain syndrome type I affects brain structure in prefrontal and motor cortex. PLoS One 2014; 9:e85372

Schlaffke L, Lissek S, Lenz M, Brüne M, Juckel G, Hinrichs T, Platen P, Tegenthoff M, Schmidt-Wilcke T. Sports and brain morphology - a voxel-based morphometry study with endurance athletes and martial artists. Neuroscience 2014; 259:35-42

Lenz M, Üçeyler N, Frettlöh J, Höffken O, Krumova EK, Lissek S, Reinersmann A, Sommer C, Stude P, Waaga-Gasser AM, Tegenthoff M, Maier C. Local cytokine changes in complex regional pain syndrome type I (CRPS I) resolve after 6 months. Pain 2013; 154:2142-2149

Reinersmann A, Maier C, Schwenkreis P, Lenz M. Complex regional pain syndrome: more than a peripheral disease. Pain Manag 2013; 3:495-502

Höffken O, Tannwitz J, Lenz M, Sczesny-Kaiser M, Tegenthoff M, Schwenkreis P. Influence of parameter settings on paired-pulse-suppression in somatosensory evoked potentials: a systematic analysis. Clin Neurophysiol 2013; 124:574-580

Höffken O, Lenz M, Höckelmann N, Dinse HR, Tegenthoff M. Noradrenergic modulation of human visual cortex excitability assessed by paired-pulse visual-evoked potentials. Neuroreport 2012; 23:707-711

Höffken O, Lenz M, Sczesny-Kaiser M, Dinse HR, Tegenthoff M. Phosphene thresholds correlate with paired-pulse suppression of visually evoked potentials. Brain Stimul 2013; 6:118-121

Lenz M, Höffken O, Stude P, Lissek S, Schwenkreis P, Reinersmann A, Frettlöh J, Richter H, Tegenthoff M, Maier C. Bilateral somatosensory cortex disinhibition in complex regional pain syndrome type I. Neurology 2011; 77:1096-1101

Lenz M, Tegenthoff M, Kohlhaas K, Stude P, Höffken O, Gatica Tossi MA, Kalisch T, Kowalewski R, Dinse HR. Increased excitability of somatosensory cortex in aged humans is associated with impaired tactile acuity. J Neurosci 2012; 32: 1811-1816

Kalisch T, Richter J, Lenz M, Kattenstroth JC, Kolankowska I, Tegenthoff M, Dinse HR. Questionnaire-based evaluation of everyday competence in older adults. Clin Interv Aging 2011; 6:37-46

Höffken O, Lenz M, Tegenthoff M, Schwenkreis P. Multichannel SEP-recording after paired median nerve stimulation suggests origin of paired-pulse inhibition rostral of the brainstem. Neurosci Lett 2010; 468:308-311

Höffken O, Stude P, Lenz M, Bach M, Dinse HR, Tegenthoff M. Visual paired-pulse stimulation reveals enhanced visual cortex excitability in migraineurs Eur J Neurosci 2009; 30:714-720