Master Topics - offered by ISTEM study course

Topics Offered by .....
- iPS based in vitro modelling of Crigler-Najjar syndrome type 1
- Characterisation of MSCs and iPSCs  derived from urine
Prof. Dr. James Adjaye
Inst. für Stammzellforschung und Regenerative Medizin
HHU Düsseldorf
Tel.: 0049(0)211-81-08192
 - Reduction of ischemic and reperfusion damage in skeletal muscle
PD Dr. med. Björn Behr
Plastische Chirurgie Bergmannsheil
Bürkle-de-la-Camp-Platz 1
44789 Bochum
 - Stem cell studies and cell culture optimization using a 3D-Bioprinter
 - Studying autophagy in epithelial-mesenchymal transitions in the chicken embryo
 - Studying autophagy in developmental processes in murine iPS cells
 - Morphological and molecular analysis of Math6 knockout mice
 - Functional analysis of Math6 in the myogenic differentiation
   of adult skeletal muscle stem cells using knockout mice

- Differential myogenic microRNA expression profiling in adult skeletal muscle stem cells
   of Math6 knockout mice
Prof. Dr. Beate Brand-Saberi
Anatomie und Molekulare Embryologie
Ruhr-Universität Bochum
MA 5/158
 - Molecular analysis of genes co-regulated by Bcl11a/b transcription factors in murine
   neocortical development
Professor Dr. Stefan Britsch
Institute of Molecular and Cellular Anatomy
Ulm University
Albert-Einstein-Allee  11
89081 Ulm
0731/500 23100 
 - Adhesion of circulating cancer stem cells to endothelial cells in vitro 
 - Selective inhibition of cancer stem cells by the combination of ionophors (salinomycin)
   and metformin
 - Role of the acid sphingomyelinase/ ceramide pathway in post-ischemic   neuroplasticity and angiogenesis
Prof. Dr. med.  Irenäus Adamietz
Klinik für Strahlentherapie und Radio-Onkologie
Marien Hospital Herne - Universitätsklinikum der Ruhr-Universität Bochum Hölkeskampring 40, 44625 Herne Fon: 02323 499-1531
Fax: 02323 499-3306
- Application of network inference algorithms for boolean modeling of protein co-expression networks
PD Dr. Eisenacher / Dr. Kohl

Dr. Michael Kohl
Group Leader Algorithmic
Proteomics Medizinisches Proteom-Center
DEPARTMENT Medical Bioinformatics
Building ProDi E2.244 | Gesundheitscampus 4 |
 D-44801 Bochum
Fon +49 (0)234 32-18108 | Fax +49 (0)234 32-tba
Hematopoietic Stem Cell Transplantation:

- Impact of the peptidome on T cell alloreactivity to polymorphic human leukocyte antigen (HLA) molecules
- Immunogenicity of antigen presenting cells after Crispr-Cas9 silencing of HLA class II
- Characterization of the human T cell receptor repertoire responding to HLA mismatches after
  hematopoietic stem cell transplantation
- Effect of amino acid polymorphism in HLA-DP on the repertoire of presented peptides
- Role of HLA-DM for the immunogenicity of leukemia cells after hematopoietic stem cell transplantation
- Characterization of HLA loss leukemia immune escape after hematopoietic stem cell transplantation
  by droplet digital PCR 
Prof. Dr. med. Katharina Fleischhauer
University Hospital Essen
Institute for Experimental Cellular Therapy
Hufelandstraße 55
D-45122 Essen
Telefon  +49 201 / 723-4582
- Influence of conditionally induced Reelin-knockout on hippocampal stem cell
  proliferation and differentiation
Prof. Eckart Förster
Institut für Neuroanatomie und
molekulare Hirnforschung
Ruhr-Universität Bochum
MA 6 Süd/161
Human Hematopoiesis:
- The impact of signaling pathways on early hematopoiesis and dendritic cell development
- Establishment of novel reporter cell lines to dissect the activity of MSC-EVs
- Impact of different EV purification methods on the biologic activity of MSC-EVs
- Analysis of the heterogeneity of plasma derived extracellular vesicles
- Impact of small molecules on the EV secretion of mesenchymal stem cells
- Analysis of the lipid raft composition of different MSC-EV subpopulations
PD. Dr. rer. nat. Bernd Giebel
University Hospital Essen
Institute for Transfusion Medicine
Hufelandstraße 55
45122 Essen
Tel. 0201/723-4204
- Secondary Resistance towards targeted therapies in colon and pancreatic cancer: The role of persister cells in the context of the stem cell-​like characteristics of persister cells
Prof. Dr. med. Stephan Hahn
Ruhr-Universität Bochum Zentrum für Klinische Forschung (ZKF)
Labor für Molekulare Gastroenterologische Onkologi (MGO) 
der Medizinischen Universitätsklinik Knappschaftsk.
Universitätsstraße 150
44780 Bochum
Tel  +49 (0) 234 32 29282 Fax  +49 (0) 234 32 14674
 - Role of the acid sphingomyelinase/ ceramide pathway in post-ischemic neuroplasticity
   and angiogenesis               
 - Effects of mescenchamal stem cell-derived exosomes on post-ischemic brain remodeling
   and plasticity            
 - Effects of GABAA antagonists on post-ischemic brain remodeling and plasticity
 - Molecular mechanisms of primary neuronal and neuronal stem cell differentiation under inflammatory
   and ischemic conditions
Prof. Dirk M. Hermann
Chair of Vascular Neurology,
Dementia and Ageing Research/ NeuroScienceLab
University Hospital Essen
Hufelandstraße 55,
45122 Essen
 - Development of the head trunk transition region
Prof. Dr. med. Ruijin Huang
Institute of Anatomy University of Bonn
Nussallee 10, 53115 Bonn
Tel. 0228-73-5618
- The role of hCAP-18/LL-37 as a mediator between epidermal and mesenchymal stem cells
  during wound healing and skin tissue regeneration
Dr. Frank Jacobsen
Arbeitsgruppe Experimentelle Plastische Chirurgie Klinik
für Plastische Chirurgie und
Schwerbrandverletzte Handchirurgiezentrum
Operatives Referenzzentrum für Gliedmaßentumore
BG Universitätskliniken Bergmannsheil
Ruhr-Universität Bochum
Bürkle-de-la Camp Platz 1

D-44789 Bochum

Klinik 	+49 234 302-3542
Fax		+49 234 90488436
Mobile 	+49 179 2027104
- "Development of Gut-on-a-chip model for disease modelling"
Dr. Dorota Kurek            
Head of Research/Model Development Mimetas
 - Analysis of neuronal proteins within in the human brain in the context of ageing                
 - Analysis of neuronal proteins within in the human brain in the context of
   neurodegenerative diseases                
 - Analysis of autoantibodies in human diseases                
 - Analysis of autoantibodies in healthy individuals                              
 - Proteome analyses of CSF and exosomes for the identification of biomarkers
   for spinal cord injury
Prof. Dr. Katrin Marcus
Ruhr-Universität Bochum
Zentrum für klinische Forschung (ZKF)  
Raum 1.055
- Isolation, purity, cultivation and characterization
- Differentiation capacity
 - Behavior in an autologous plasmaclot-matix as cell carrier for cell therapies
 - Analysis of olfactory stem cells in contact to cerebrospinal fluid: prerequisite for cell therapies after
   spinal cord injuries
 - Stem cells for fracture healing
 - Role of stem cells for induced membranes (surgical Masquelet        technique)
Jun.-Prof. Dr. rer. nat. Christina Sengstock
Chirurgische Forschung  
Chirurgische Universitätsklinik und Poliklinik
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH Bürkle de la Camp-Platz 1 44789 Bochum Tel.: 0234/302-4724
- Generation of CRISPR/Cas9 modified hESCs and iPSCs 
- Modelling of genetic diseases with human pluripotent cells (Angelman Syndrome, Retinoblastoma,
  Uveal melanoma)
- The influence of BAP1 knock-out on the methylome of human iPSCs
PD Dr. Laura Steenpass
Universitätsklinikum Essen (AöR)
Universität Duisburg-Essen
Institut für Humangenetik (IG1, 2.OG)
Hufelandstr. 55
D-45147 Essen
Phone: +49 (0)201 723 4539
Fax: +49 (0)201 723 5900
- Extracellular vesicles as a potential diagnostic tool to measure cancer stem cell heterogeneity
   in pediatric Rhabdoid Tumor patients. 
- Profiling of extracellular vesicles from pediatric AML patients to track the evolution of rare leukemic
  stem cells sub-clones in the hematopoietic compartment.
- Extracellular vesicles based liquid biopsy in solid tumor patients (either melanoma or the cancer
  of head and neck) 
  to track the clonal evolution and resistance of aggressive cancer stem cells.
Basant Kumar Thakur, Ph.D.
Experimental Molecular Research Pediatric Clinic III
University Clinic of Essen
Hufelandstraße 55
D- 45147 Essen
Tel: +49 201/ 723-2502 
 - Cell-to-cell transmission of pathogenic proteins linked to neurodegenerative diseases in humans 
Prof. Dr. Jörg Tatzelt
Institut für Biochemie und Pathobiochemie,
Abteilung Biochemie Neurodegenerativer Erkrankungen
Ruhr-Universität Bochum
MA 2/145
0234/ 32-22429
 - Effect of New Cathepsin K Inhibitors on the Osteogenic and Vascular Cell Differentiation
Prof. Dr. Edda Tobiasch
Hochschule Bonn-Rhein-Sieg
von-Liebig-Str. 20
53359 Rheinbach
- Biochemical characterization of a germeline-specific epitope on the surface of the mammalian mitochondrium
Prof. Dr. Christoph Viebahn
Zentrum Anatomie   Uni. Göttingen
Kreuzbergring 36
D−37075 Göttingen
+49 (0)551 397001
 - Analysis of an in vitro model for neural differentiation  
 - Differentiation capacities for murine neural stem cells            
 - Influence of Cytochrome C on neural stem cell behavior 
Prof. Dr. Stefan Wiese
AG Molecular cell biology
Ruhr-Universität Bochum, NDEF 05
 - Modeling skeletal muscular dystrophies with patient-derived induced pluripotent stem cells
PD Dr. Holm Zähres
Anatomie und Molekulare Embryologie
Ruhr-Universität Bochum
MA 5/152
- Developing an in vitro model for hypertrophy induction of human induced pluripotent
  stem cell-derived cardiomyocytes (hiPSC-CMs)
Dr. Robert Zweigerdt
and Dr. Henning Kempf
Medizinische Hochschule Hannover (MHH),
Abteilung: Leibniz Research Laboratories
for Biotechnology and Artificial Organs (LEBAO)
Carl-Neuberg-Str.1, 30625 Hannover
0511 / 532    8773