Ictal heterogeneity in the awake thalamocortical system

Tuesday, April 18th 2023, 10:00, Seminar Room FNO - 01 / 117

Magor L. Lorincz
Physiology, Anatomy and Neuroscience Department, University of Szeged, Hungary

Stressful Cortico-thalamo-cortical oscillations important for various physiological and pathological functions are driven by a variety of cortical and thalamic, cell-intrinsic and synaptic interactions. However, the corticothalamic neuronal ensemble dynamics characterizing paroxysmal oscillations of absence seizures (ASs) have remained elusive. Using ensemble recordings from identified neurons, we show that pyramidal neurons and various inhibitory interneurons of the primary somatosensory cortex, first- and higher order thalamic relay neurons and reticular thalamic neurons are characterized by a surprisingly heterogeneous ictal activity in awake behaving animals. This heterogeneity was present both in the mean activity of neurons showing cell-type and sub-type specific differences and at the level of individual seizures. Our results question the validity of hyperexcitability resulting from runaway excitation and lack of inhibition and argue that ictal activity is one of the most heterogeneous brain state.

Dirk Jancke
Bernstein-Group for Computational Neuroscience, Institute for Neural Computation, Ruhr University Bochum

Guests are welcome!