Publikationen

Im folgenden finden Sie die wesentlichen Publikationen der Mitarbeiter unserer Arbeitsgruppe aus den letzten Jahren.

2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 vor 2008

2019

Regulation of lung immunity by dendritic cells: Implications for asthma, chronic obstructive pulmonary disease and infectious disease

  Peters M, Peters K, Bufe A
Innate Immun. 2019 Aug;25(6):326-336
PubMed

Anti-thrombogenic coatings for devices in neurointerventional surgery: Case report and review of the literature

  Henkes H, Bhogal P, Aguilar Pérez M, Lenz-Habijan T, Bannewitz C, Peters M, Sengstock C, Ganslandt O, Lylyk P, Monstadt H
Interv Neuroradiol. 2019 Jun 27. [Epub ahead of print]
PubMed

A patent on the synthesis of arabino-oligosaccharides for regulation of immune responses in the lung

  Peters M
Allergy. 2019 May 30.  [Epub ahead of print]
PubMed

Nocturnal asthma is affected by genetic interactions between RORA and NPSR1

  Gaertner VD, Michel S, Curtin JA, Pulkkinen V, Acevedo N, Söderhäll C, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Pershagen G, Melén E, Simpson A, Custovic A, Kere J, Kabesch M
Pediatr Pulmonol. 2019 Jun;54(6):847-857. Epub 2019 Mar 29.
PubMed

The monocyte-dependent immune response to bacteria is suppressed in smoking-induced COPD

  Knobloch J, Panek S, Yanik SD, Jamal Jameel K, Bendella Z, Jungck D, Bürger P, Bülthoff E, Struck B, Giannakis N, Rupp J, Kronsbein J, Peters M, Koch A
J Mol Med (Berl). 2019 Mar 30. [Epub ahead of print]
PubMed

Nocturnal asthma is affected by genetic interactions between RORA and NPSR1

  PubMed

2018

Sphingosine-1-phosphate (S1P) induces potent anti-inflammatory effects in vitro and in vivo by S1P receptor 4-mediated suppression of 5-lipoxygenase activity

  Fettel J, Kühn B, Guillen NA, Sürün D, Peters M, Bauer R, Angioni C, Geisslinger G, Schnütgen F, Meyer Zu Heringdorf D, Werz O, Meybohm P, Zacharowski K, Steinhilber D, Roos J, Maier TJ
FASEB J. 2018 Sep 6.  [Epub ahead of print]
PubMed

Hydrophilic Stent Coating Inhibits Platelet Adhesion on Stent Surfaces: Initial Results In Vitro

  Lenz-Habijan T, Bhogal P, Peters M, Bufe A, Martinez Moreno R, Bannewitz C, Monstadt H, Henkes H
Cardiovasc Intervent Radiol. 2018 Jul 23.  [Epub ahead of print]
PubMed

Nitric oxide dependent signaling via cyclic GMP in dendritic cells regulates migration and T-cell polarization.

  Gnipp S, Mergia E, Puschkarow M, Bufe A, Koesling D, Peters M
Sci Rep. 2018 Jul 20;8(1):1096
PubMed

Side effects during subcutaneous immunotherapy in children with allergic diseases

  Tophof MA, Hermanns A, Adelt T, Eberle P, Gronke C, Friedrichs F, Knecht R, Mönter E, Schöpfer H, Schwerk N, Steinbach J, Umpfenbach HU, Weißhaar C, Wilmsmeyer B, Bufe A
diatr Allergy Immunol. 2018 May;29(3):267-274.
PubMed

Effect of grass sublingual tablet immunotherapy is similar in children and adults: A Bayesian approach to design pediatric sublingual immunotherapy trials

  Kaur A, Skoner D, Ibrahim J, Li Q, Lockey RF, Blaiss M, Bufe A, Andersen JS, Canonica GW, Nolte H
J Allergy Clin Immunol. 2018 May;141(5):1744-1749
PubMed

Results from the 5-year SQ grass sublingual immunotherapy tablet asthma prevention (GAP) trial in children with grass pollen allergy

  Valovirta E, Petersen TH, Piotrowska T, Laursen MK, Andersen JS, Sørensen HF, Klink R; GAP investigators
J Allergy Clin Immunol. 2018 Feb;141(2):529-538
PubMed

2017

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.

  Roos J, Peters M, Maucher IV, Kühn B, Fettel J, Hellmuth N, Brat C, Sommer B, Urbschat A, Piesche M, Vogel A, Proschak E, Blöcher R, Buscató E, Häfner AK, Matrone C, Werz O, Heidler J, Wittig I, Angioni C, Geisslinger G, Parnham MJ, Zacharowski K, Steinhilber D, Maier TJ
Antioxid Redox Signal.
2017 Sep 8. [Epub ahead of print]
PubMed

A Bioassay for the Determination of Lipopolysaccharides and lipoproteins

  Peters M, Bonowitz P, Bufe A
Methods Mol Biol. 2017;1600:143-150.
PubMed

Medical diagnostics for indoor mold exposure

  Hurraß J, Heinzow B, Aurbach U, Bergmann KC, Bufe A, Buzina W, Cornely OA, Engelhart S, Fischer G, Gabrio T, Heinz W, Herr CE, Kleine-Tebbe J, Klimek L, Köberle M, Lichtnecker H, Lob-Corzilius T, Merget R, Mülleneisen N, Nowak D, Rabe U, Raulf M, Seidl HP, Steiß JO, Szewszyk R, Thomas P, Valtanen K, Wiesmüller GA
Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):305-328.
PubMed

2016

Medizinisch klinische Diagnostik bei Schimmelpilzexposition in Innenräumen

  Wiesmüller GA, Heinzow B, Aurbach U, Bergmann KC, Bufe A, Buzina W, Cornely OA, Engelhart S, Fischer G, Gabrio T, Heinz W, Herr CE, Kleine-Tebbe J, Klimek L, Köberle M, Lichtnecker H, Lob-Corzilius T, Merget R, Mülleneisen N, Nowak D, Rabe U, Raulf M, Seidl HP, Steiß JO, Szewszyk R, Thomas P, Valtanen K, Hurraß J
Pneumologie. 2016 Nov;70(11):699-741. Epub 2016 Nov 9
PubMed

Infant formula containing galacto-and fructo-oligosaccharides and Bifidobacterium breve M-16V supports adequate growth and tolerance in healthy infants in a randomised, controlled, double-blind, prospective, multicentre study

  Abrahamse-Berkeveld, M, Alles M, Franke-Beckmann E, Helm K, Knecht R, Köllges R, Sandner B, Knol J, Ben Amor K and Bufe A
J Nutr Sci. Epub 2016 Oct. 28, vol. 5, e42,
 

Mucosal expression of DEC-205 targeted allergen alleviates an asthmatic phenotype in mice.

  Maaske A, Devos FC, Niezold T, Lapuente D, Tannapfel A, Vanoirbeek JA, Überla K, Peters M, Tenbusch M
J Control Release. 2016 Jun 30. pii: S0168-3659(16)30420-5 [Epub ahead of print]
PubMed

Systemic ocular antigen immunization leads only to a minor secondary immune response.

  Kuehn S, Stellbogen M, Noristani R, Peters M, Dick HB, Joachim SC
J Neuroimmunol. 2016 Apr 15;293:114-22. Epub 2016 Feb 28.
PubMed

Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.

  Schieck M, Schouten JP, Michel S, Suttner K, Toncheva AA, Gaertner VD, Illig T, Lipinski S, Franke A, Klintschar M, Kalayci O, Sahiner UM, Birben E, Melén E, Pershagen G, Freidin MB, Ogorodova LM, Granell R, Henderson J, Brunekreef B, Smit HA, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Jonigk D, Postma DS, Koppelman GH, Vonk JM, Timens W, Boezen HM, Kabesch M
J Allergy Clin Immunol. 2016 Feb 20.pii: S0091-6749(16)00052-X  [Epub ahead of print]
PubMed

Allergy-protective arabinogalactan modulates human dendritic cells via c-type-lectins and inhibition of NFKβ

  Peters M, Guidato PM, Peters K, Megger DA, Sitek B, Classen B, Heise EM, Bufe A.
J Immunol. 2016 Feb 15;196(4):1626-35. Epub 2016 Jan 8.
PubMed

Influence of an Allergen-specific Th17 Response on Remodeling of the Airways

  Peters M, Köhler-Bachmann S, Lenz-Habijan T, Bufe A,
Am J Respir Cell Mol Biol. 2016 Mar,54(3):350-8. doi: 10.1165
PubMed

2015

Childhood asthma is associated with mutations and gene expression differences of ORMDL genes which can interact

  Toncheva AA, Potaczek DP, Schedel M, Gersting SW, Michel S, Krajnov N, Gaertner VD, Klingbeil JM, Illig T, Franke A, Winkler C, Hohlfeld JM, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Muntau AC, Kabesch M
Allergy. 2015 Oct;70(10):1288-99
PubMed

Polymorphisms related to ORMDL3 are associated with asthma susceptibility, alterations in transcriptional regulation of ORMDL3, and changes in TH2 cytokine levels

  Schedel M, Michel S, Gaertner VD, Toncheva AA, Depner M, Binia A, Schieck M, Rieger MT, Klopp N, von Berg A, Bufe A, Laub O, Rietschel E, Heinzmann A, Simma B, Vogelberg C, Genuneit J, Illig T, Kabesch M
J Allergy Clin Immunol. 2015 Oct;136(4):893-903
PubMed

Safety of sublingual immunotherapy Timothy grass tablet in subjects with allergic rhinitis with or without conjunctivitis and history of asthma

  Maloney J, Durham S, Skoner D, Dahl R, Bufe A, Bernstein D, Murphy K, Waserman S, Berman G, White M, Kaur A, Nolte H
Allergy. 2015 Mar;70(3):302-9
PubMed

2014

Allergy and asthma prevention 2014

  Nieto A1, Wahn U, Bufe A, Eigenmann P, Halken S, Hedlin G, Høst A, Hourihane J, Just J, Lack G, Lau S, Matricardi PM, Muraro A, Papadopoulos N, Roberts G, Simpson A, Valovirta E, Weidinger S, Wickman M, Mazon A.
Pediatr Allergy Immunol. 2014 Oct;25(6):516-33
PubMed

Guideline on allergen-specific immunotherapy in IgE-mediated allergic diseases

  Pfaar O, Bachert C, Bufe A, Buhl R, Ebner C, Eng P, Friedrichs F, Fuchs T, Hamelmann E, Hartwig-Bade D, Hering T, Huttegger I, Jung K, Klimek L, Kopp MV, Merk H, Rabe U, Saloga J, Schmid-Grendelmeier P, Schuster A, Schwerk N, Sitter H, Umpfenbach U, Wedi B, Wöhrl S, Worm M, Kleine-Tebbe J, Kaul S, Schwalfenberg A
Allergo J Int. 2014;23(8):282-319
PubMed

Fine-mapping of IgE-associated loci 1q23, 5q31, and 12q13 using 1000 Genomes Project data

  Sharma V, Michel S, Gaertner V, Franke A, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Zeilinger S, Illig T, Schedel M, Potaczek DP, Kabesch M
Allergy. 2014 Aug;69(8):1077-84
PubMed

S3-Guideline on allergy prevention: 2014 update

  Schäfer T, Bauer CP, Beyer K, Bufe A, Friedrichs F, Gieler U, Gronke G, Hamelmann E, Hellermann M, Kleinheinz A, Klimek L, Koletzko S, Kopp M, Lau S, Müsken H, Reese I, Schmidt S, Schnadt S, Sitter H, Strömer K, Vagts J, Vogelberg C, Wahn U, Werfel T, Worm M, Muche-Borowski C
Allergo J Int. 2014;23(6):186-199
PubMed

Genetic variation in T(H)17 pathway genes, childhood asthma, and total serum IgE levels

  Schieck M, Michel S, Suttner K, Illig T, Zeilinger S, Franke A, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Kerzel S, Kabesch M
J Allergy Clin Immunol. 2014 Mrz; 133(3): 888-91
PubMed

Die Grenzfäche Lunge und ihr Immunsystem

  Bufe A, Peters M, Pabst R, Tschernig T
Allergo J 2014 Mrz;23(2): 14-16
Link

Economic evaluation of SQ-standardized grass allergy immunotherapy tablet (Grazax) in children

  Ronaldson S, Taylor M, Bech PG, Shenton R, Bufe A
Clinicoecon Outcomes Res. 2014; Apr 8;6:187-96. eCollection 2014
PubMed

A role of FCER1A and FCER2 polymorphisms in IgE regulation

  Sharma V, Michel S, Gaertner V, Franke A, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Potaczek DP, Kabesch M
Allergy. 2014 Feb;69(2): 231-236
PubMed

2013

Allergien in der Pathogenese des Asthmas

  Bufe A, Peters M
pädiat prax. 2013;80: 593-600
Link

A novel synthetic lipopeptide is allergy-protective by the induction of LPS-tolerance.

  Stiehm M, Peters K, Wiesmüller K-H, Bufe A, Peters M
Clin Exp Allergy. 2013 Jul;43(7): 785-97
PubMed

Different FCER1A polymorphisms influence IgE levels in asthmatics and non-asthmatics.

  Potaczek DP, Michel S, Sharma V, Zeilinger S, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, Illig T, Kabesch M.
Pediatr Allergy Immunol. 2013 Aug;24(5): 441-449
PubMed

Clinical efficacy and immunological response in children is similar to that of adults after the first treatment season with SQ-standardized grass allergy immunotherapy tablet in two randomized trials

  Bufe A, Eberle P, Tholstrup B, Henmar H, Durham SM
Allergologie. 2013 May; 36(5): 238-245
Abstract

Polymorphisms in extracellular signal-regulated kinase family influence genetic susceptibility to asthma.

  Pandey RC, Michel S, Schieck M, Binia A, Liang L, Klopp N, Franke A, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Illig T, Kabesch M
J Allergy Clin Immunol. 2013 Apr; 131(4): 1245-1247
PubMed

Proteolytic activity in cowshed dust extracts induces C5a release in murine bronchoalveolar lavage fluids which may account for its protective properties in allergic airway inflammation.

  Stiehm M, Bufe A, Peters M
Thorax 2013 Jan; 68(1): 31-38
PubMed

A ternary complex consisting of AICD, FE65, and TIP60 down-regulates Stathmin1

  Müller T, Schrötter A, Loosse C, Pfeiffer K, Theiss C, Kauth M, Meyer HE, Marcus K
BBA - Proteins Proteomics 2013 Jan; 1834(1): 387-394
PubMed

2012

Genetic variation in the TLR signaling pathway is associated with childhood asthma.

  Pandey RS, Michel S, Tesse R, Binia A, Schedel M, Liang L, Klopp N, Franke A, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Illig T, Kabesch M
J Allergy Clin Immunol. 2013 Feb; 131(2): 602-605
 PubMed

Genetic variants in Protocadherin-1, bronchial hyper-responsiveness, and asthma subphenotypes in German children.

  Toncheva AA, Sutter K, Michel S, Klopp N, Illig T, Batschun T, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Frischer T, Genuneit J, von Mutius E, Kabesch M
Pediatr Allergy Immunol. 2012 Nov; 23(7):636-641
PubMed

EAACI: A European Decleration on Immunotherapy. Designing the future of allergen specific immunotherapy

  Calderon MA, Demoly P, Gerth van Wijk R, Bousquet J, Sheikh A, Frew A, Scadding G, Bachert C, Malling HJ, Valenta R, Bilo B, Nieto A, Akdis C, Just J, Vidal C, Varga EM, Alvarez-Cuesta E, Bohle B,  Bufe A, Canonica WG, Cardona V, Dahl R, Didier A, Durham SR, Eng P, Fernandez-Rivas M, Jacobsen L, Jutel M, Kleine-Tebbe J, Klimek L, Lötvall J, Moreno C, Mosges R, Muraro A, Niggemann B, Pajno G, Passalacqua G, Pfaar O, Rak S, Senna G, Senti G, Valovirta E, van Hage M, Virchow JC, Wahn U, Papadopoulos N
Clin Transl Allergy. 2012 Oct 30;2(1):20
PubMed

Stepwise isolation of human peripheral erythrocytes, T-lymphocytes and monocytes for blood cell proteomics

  Brosseron F, May C, Schoenebeck B, Tippler B, Woitalla D, Kauth M, Brockmann K, Meyer HE, Berg D, Bufe A, Marcus K
Promeotics Clin Appl. 2012 Oct; 6(9-10):497-501
PubMed

High-dose sublingual immunotherapy with single-dose aqueous grass pollen extract in children is effective and safe. A double-blind, placebo-controlled study

  Wahn U, Klimek L, Ploszczuk A, Adelt T, Sander B, Trebas-Pietras E, Eberle P, Bufe A and SLIT Study Group
JACI. 2012 Oct; 130(4): 886-893
 PubMed

SIT: efficacy depends on product, not on route of application

  Bachert C, Walter Canonica G, Bufe A 
Pediatr Allergy Immunol. 2012 Jun; 23(4): 401
PubMed

Perspectives on allergen-specific immunotherapy in childhood: An EAACI position statement

  Calderon MA, Gerth van Wijk R, Eichler I, Matricardi PM, Varga EM, Kopp MV, Eng P, Niggemann B, Nieto A, Valovirta E, Eigenmann PA, Pajno G, Bufe A, Halken S, Beyer K, Wahn U
Pediatr Allergy Immunol. 2012 June; 23 (4): 300-306
PubMed

Anti-inflammatory modulation of immune response by probiotic Escherichia coli Nissle 1917 in human blood mononuclear cells

  Guettsches AK, Loeseke S, Zaehringer U, Sonnenborn U, Enders C, Gatermann S, Bufe A
Innate Immun. 2012 Apr; 18(2): 204-216
PubMed

A bioassay for determinaton of lipopolysaccharide in environmental samples

  Peters M, Fritz P, Bufe A
Innate Immun. 2012;18(5): 694-9
 PubMed

2011

Vom Stallstaub zum Molekül: Mechanismen der allergieprotektiven Wirkung

  Peters M, Bufe A
Allergo J. 2011; 20: 460-465
Abstract

Arabinogalactan isolted from grass protects from allergic disease

  Peters M, Bufe A
Allergologie. 2011 Sep; 34(9): 461-466
Abstract

Flow cytometry confirms reticulate evolution and reveals triploidy in Central European Diphasiastrum taxa (Lycopodiaceae, Lycophyta).

  Bennert HW, Horn K, Kauth M, Fuchs J, Bisgaard Jakobsen IS, Ollgaard B, Schnittler M, Steinberg M, Viane R
Ann Bot. 2011 Okt; 108(5): 867-876. Epup 2011 Aug 10.
PubMed

Design and Recruitment for the GAP Trail, Investigating the Preventive Effect on Asthma Development of an SQ-Standardized Grass Allergy Immunotherapy Tablet in Children with Grass Pollen-Induced Allergic Rhinoconjunctivitis

  Valovirta E, Berstad A K H, de Blic J,, Bufe A, Eng P, Halken S, Ojeda P, Roberts G, Tommerup L, Varga E-M, Winnergard
Clin Ther. 2011 Oct;33(10):1537-46. Epub 2011 Oct 13.
 PubMed

Indications and evidence base for specific immunotherapy in childhood.

Ott H, Bufe A, Merk HF
Hausarzt 2011 Sep 62:671-6
PubMed

Comparison of metabolites in exhaled breath and bronchoalveolar lavage fluid samples in a mouse model of asthma.

  Neuhaus S, Seifert L, Vautz W, Nolte J, Bufe A, Peters M
J Appl Physiol. 2011 Jul 21. [Epub ahead of print]
PubMed

Specific immunotherapy in children.

  Bufe A, Roberts G
Clin Exp Allergy. 2011 Sep;41(9):1256-62. doi: 10.1111/j.1365-2222.2011.03740.x . Epub 2011 Apr 25.

2010

Unifying Candidate Gene and GWAS Approaches in Asthma

 
Michel S, Liang L, Depner M, Klopp N, Ruether A, Kumar A, Schedel M, Vogelberg C, von Mutius E, von Berg A, Bufe A, Rietschel E, Heinzmann A, Laub O, Simma B, Frischer T, Genuneit J, Gut IG, Schreiber S, Lathrop M, Illig T, Kabesch M.
PLoS One. 2010 Nov 12;5(11):e13894.
PubMed

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.

 
Peters M, Kauth M, Scherner O, Gehlhar K, Steffen I, Wentker P, von Mutius E, Holst O, Bufe A
J Allergy Clin Immunol. 2010 Sep;126(3):648-56.e1-4.
PubMed

Conference Scene: Summary report from EAACI: London 2010.

 
Stiehm M, Bufe A.
Clin Exp Allergy. 2010 Jul;40(7):998-1006. Epub 2010 Apr 13.
PubMed

T-cell polarization depends on concentration of the danger signal used to activate dendritic cells

 
Peters M, Dudziak K, Stiehm M, Bufe A
Immunol Cell Biol. 2010 Jul;88(5):537-44. Epub 2010 Feb 2.
PubMed

Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions

 
Hohlfeld JM, Holland-Letz T, Larbig M, Lavae-Mokhtari M, Wierenga E, Kapsenberg M, van Ree R, Krug N, Bufe A.
Clin Exp Allergy. 2010 Jul;40(7):998-1006. Epub 2010 Apr 13.
PubMed

Viral colonization in intubated patients: initial pathogen pattern and follow-up

 
Hauptmeier BM, Borg I, Rohde G, Anders A, Kronsbein J, Gatermann S, Bufe A, Blum T, Schultze-Werninghaus G, Bauer TT.
Clin Respir J. 2010 Jul;4(3):139-46.
PubMed

Analyses of mouse breath with ion mobility spectrometry: a feasibility study

 
Vautz W, Nolte J, Bufe A, Baumbach JI, Peters M.
J Appl Physiol. 2010 Mar;108(3):697-704. Epub 2010 Jan 14.
PubMed

2009

Safety and efficacy in children of an SQ-standardised grass allergen tablet for sublingual immunotherapy.

 
Bufe A, Eberle P, Francke-Beckmann E, Funck J, Kimmig M, Klimek L, Knecht R, Stephan V, Tholstrup B, Weißhaar C, Kaiser F.
J Allergy Clin Immunol. 2009 Jan;123(1):167-173.e7.
PubMed

2008

Modulation of dendritic cell function by cowshed dust extract.

 
Gorelik L, Kauth M, Gehlhar K, Bufe A, Holst O, Peters M.
(2008) Innate Immunity 14(6):345-355
PubMed

Inflammatory Response in Acute Viral Exacerbations of COPD.

 
Rohde G, Borg I, Wiethege A, Kauth M, Jerzinowski S, An Duong Dinh T, Bauer TT, Bufe A, Schultze-Werninghaus G.
Infection. 2008 Oct;36(5):427-33. Epub 2008 Sep 15.
PubMed

Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties

 
Vogel K, Blümer N, Korthals M, Mittelstädt J, Garn H, Ege M, von Mutius E, Gatermann S, Bufe A, Goldmann T, Schwaiger K, Renz H, Brandau S, Bauer J, Heine H, Holst O.
J Allergy Clin Immunol. 2008 Aug; 122(2):307-12
PubMed

Wie funktioniert eigentlich die sublinguale Immuntherapie?

 
Bufe A.
Internistische Praxis 2008 48(2):379-388
 

2007

Safety of Specific Sublingual Immunotherapy with SQ Standardised Grass Allergen Tablets in Children

 
Ibanez MD, Kaiser F, Knecht R, Armentia A, Schopfer H, Tholstrup B, Bufe A.
Pediatr Allergy Immunol. 2007 Sep;18(6):516-522
PubMed

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

 
Miriam F. Moffatt, Michael Kabesch, Liming Liang, Anna L. Dixon, David Strachan, Simon Heath, Martin Depner, Andrea von Berg, Albrecht Bufe, Ernst Rietschel, Andrea Heinzmann, Burkard Simma, Thomas Frischer, Saffron A. G. Willis-Owen, Kenny C. C. Wong, Thomas Illig, Christian Vogelberg, Stephan K. Weiland, Erika von Mutius, Gonçalo R. Abecasis, Martin Farrall, Ivo G. Gut, G. Mark Lathrop & William O. C. Cookson
Nature. 2007 Jul 26;448:470-473
PubMed

Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties.

 
Debarry J, Garn H, Hanuszkiewicz A, Dickgreber N, Blumer N, von Mutius E, Bufe A, Gatermann S, Renz H, Holst O, Heine H.
J Allergy Clin Immunol. 2007 May 2;
PubMed

Anti-BDCA-4 (neuropilin-1) antibody can suppress virus-induced IFN-alpha production of plasmacytoid dendritic cells.

 
Grage-Griebenow E, Loseke S, Kauth M, Gehlhar K, Zawatzky R, Bufe A.
Immunol Cell Biol. 2007 Apr 3;
PubMed

Synergistically upregulated interleukin-10 production in cocultures of monocytes and T cells after stimulation with respiratory syncytial virus.

 
Kauth M, Grage-Griebenow E, Rohde G, Anhenn O, Wiethege A, Schultze-Werninghaus G, Bufe A.
Int Arch Allergy Immunol. 2007;142(2):116-26
PubMed

2006

Clinical index-score and the ALMA study.

 
Bufe A, Holland-Letz T.
Arb Paul Ehrlich Inst Bundesamt Sera Impfstoffe Frankf A M. 2006;(95):159-65; discussion 165-6

Impaired virus-induced interferon-alpha2 release in adult asthmatic patients.

 
Gehlhar K, Bilitewski C, Reinitz-Rademacher K, Rohde G, Bufe A.
Clin Exp Allergy. 2006 Mar;36(3):331-7.
PubMed

In vitro allergy diagnosis. Guideline of the German Society of Asthma and Immunology in conjunction with the German Society of Dermatology

 
Renz H, Becker WM, Bufe A, Kleine-Tebbe J, Raulf-Heimsoth M, Saloga J, Werfel T, Worm M.
J Dtsch Dermatol Ges. 2006 Jan;4(1):72-85.
PubMed

In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells.

 
Loseke S, Grage-Griebenow E, Heine H, Wagner A, Akira S, Bauer S, Bufe A.
Scand J Immunol. 2006 Apr;63(4):264-74.

Inhalation of stable dust extract prevents allergen induced airway inflammation and hyperresponsiveness.

 
Peters M, Kauth M, Schwarze J, Korner-Rettberg C, Riedler J, Nowak D, Braun-Fahrlander C, von Mutius E, Bufe A, Holst O.
Thorax. 2006 Feb;61(2):134-9
PubMed

Lysine as a critical amino acid for IgE binding in Phl p 5b C terminus.

 
Gehlhar K, Rajashankar KR, Hofmann E, Betzel C, Weber W, Werner S, Bufe A.
Int Arch Allergy Immunol. 2006;140(4):285-94.
PubMed

The biological effects of syngeneic and allogeneic cytokine-expressing prophylactic whole cell vaccines and the influence of irradiation in a murine melanoma model.

 
Marie-Christine Labarthe, Nicole Halanek, Lindsay Birchall, Nick Russell, Christiane Desel, Stephen Todryk, Marcus J. Peters, Aisha Lucas, Frank W. Falkenberg, Angus G. Dalgleish, Mike Whelan and Stephen John Ward.
Cancer Immunol Immunother. 2006 Mar;55(3):277-88.
PubMed

2005

Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.

 
Stemmler S, Arinir U, Klein W, Rohde G, Hoffjan S, Wirkus N, Reinitz-Rademacher K, Bufe A, Schultze-Werninghaus G, Epplen JT.
Genes Immun. 2005 May;6(3):225-30
PubMed

Characterization of modified allergen extracts by in vitro beta-hexosaminidase release from rat basophils.

 
Gehlhar K, Peters M, Brockmann K, van Schijndel H, Bufe A.
Int Arch Allergy Immunol. 2005 Apr;136(4):311-9

   
Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease.

 
Hoffjan S, Stemmler S, Parwez Q, Petrasch-Parwez E, Arinir U, Rohde G, Reinitz-Rademacher K, Schultze-Werninghaus G, Bufe A, Epplen JT.
BMC Med Genet. 2005 Sep 28;6:34
PubMed

Relevance of human metapneumovirus in exacerbations of COPD.

 
Rohde G, Borg I, Arinir U, Kronsbein J, Rausse R, Bauer TT, Bufe A, Schultze-Werninghaus G.
Respir Res. 2005 Dec 21;6:150.
PubMed

2004

Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study.

 
Bufe A, Ziegler-Kirbach E, Stoeckmann E, Heidemann P, Gehlhar K, Holland-Letz T, Braun W.
Allergy. 2004 May;59(5):498-504.
PubMed

Evaluation of a real-time polymerase-chain reaction for severe acute respiratory syndrome (SARS) associated coronavirus in patients with hospitalised exacerbation of COPD.

 
Rohde G, Borg I, Arinir U, Bufe A, Dorsten C, Schultze-Werninghaus G, Bauer TT.
Eur J Med Res. 2004 Nov 29;9(11):505-9.
PubMed

LPS-binding protein as a target molecule in allergy and asthma.

 
Bufe A, Holst O.
J Allergy Clin Immunol. 2004 Sep;114(3):583-5.
PubMed

Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in house dust, and its influence on respiratory health.

 
Van Strien RT, Engel R, Holst O, Bufe A, Eder W, Waser M, Braun-Fahrländer C, Riedler J, Nowa, MD, von Mutius and the ALEX Study team
(2004) J Allergy Clin Immunol 113:860-867
PubMed

2003

Differential expression of IFN-alpha subtypes in human PBMC: evaluation of novel real-time PCR assays.

 
Loseke S, Grage-Griebenow E, Wagner A, Gehlhar K, Bufe A.
J Immunol Methods. 2003 May 1;276(1-2):207-22
PubMed

Evaluation of a quantitative real-time PCR for the detection of respiratory syncytial virus in pulmonary diseases.

 
Borg I, Rohde G, Loseke S, Bittscheidt J, Schultze-Werninghaus G, Stephan V, Bufe A
Eur Respir J. 2003 Jun;21(6):944-51
PubMed

Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study.

 
Rohde G., Wiethege A., Borg I., Kauth M., Bauer T.T., Gillisen G., Bufe A
Thorax. 2003 Jan;58(1):37-42.
PubMed

2002

Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release.

  Bufe A, Gehlhar K, Grage-Griebenow E.
Int Arch Allergy Immunol. 2002;127(1):82-88
PubMed

Environmental exposure to endotoxin and its relation to asthma in school-age children.

 
Braun-Fahrländer C, Riedler J, Herz U, Eder W, Waser M, Grize L, Maisch S, Carr D, Gerlach F, Bufe A, Lauener RP, Schierl R, Renz H, Nowak D, von Mutius E.
N Engl J Med. 2002 Sep 19;347(12):869-77.
PubMed

Expression of CD14 and toll-like receptor 2 in farmers and 'non-farmers' children.

 
Lauener RP, Birchler T, Adamski J, Braun-Fahrländer C, Bufe A, Herz U, von Mutius E, Nowak D, Riedler J, Waser M, Sennhauser FH, and the ALEX study group.
Lancet 2002;361:465-466
PubMed

Structure of the functional domain of the major grass-pollen allergen Phl p 5b.

 
Rajashankar K, Bufe A, Weber, W, Eschenburg S, Lindner B, Betzel C.
Acta Crastallogr D Biol Crastallogr. 2002 Jul; 58(pt)7:1175-81
PubMed

2001

Discontinuous IgE-binding epitopes contain multiple continuous epitope regions: results of an epitope mapping on recombinant Hol l 5, a major allergen from velvet grass pollen.

  Schramm G, Bufe A, Petersen A, Haas H, Merget R, Schlaak M, Becker WM.
Clin Exp Allergy. 2001 Feb;31(2):331-41
PubMed

Heterogeneity of human peripheral blood monocyte subsets.

 
Grage-Griebenow E, Flad HD, Ernst M.
J Leukoc Biol. 2001 Jan;69(1):11-20. Review
PubMed

Identification of a novel dendritic cell-like subset of CD64(+) / CD16(+) blood monocytes.

  Grage-Griebenow E, Zawatzky R, Kahlert H, Brade L, Flad H, Ernst M.
Eur J Immunol. 2001 Jan;31(1):48-56.
PubMed

Significance of IgE-binding epitopes in allergic disease.

  Bufe A.
J Allergy Clin Immunol. 2001 Feb;107(2):219-21
PubMed

2000

A human monoclonal IgE antibody defines a highly allergenic fragment of the major timothy grass pollen allergen, Phl p 5: molecular, immunological, and structural characterization of the epitope-containing domain.

  Flicker S, Vrtala S, Steinberger P, Vangelista L, Bufe A, Petersen A, Ghannadan M, Sperr WR, Valent P, Norderhaug L, Bohle B, Stockinger H, Suphioglu C, Ong EK, Kraft D, Valenta R.
J Immunol. 2000 Oct 1;165(7):3849-59
PubMed

   A simple advice for the prevention of pollen-induced allergic rhinitis.

   Bufe A.
Int Arch Allergy Immunol. 2000 Jan;121(1):85-6
PubMed

Human MO subsets as defined by expression of CD64 and CD16 differ in phagocytic activity and generation of oxygen intermediates.

  Grage-Griebenow E, Flad HD, Ernst M, Bzowska M, Skrzeczynska J, Pryjma J.
Immunobiology. 2000 May;202(1):42-50.
PubMed

 T cell reactivity with allergoids: influence of the type of APC.

  Kahlert H, Grage-Griebenow E, Stuwe HT, Cromwell O, Fiebig H.
J Immunol. 2000 Aug 15;165(4):1807-15.
PubMed

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages.

 
Scheuerer B, Ernst M, Durrbaum-Landmann I, Fleischer J, Grage-Griebenow E, Brandt E, Flad HD, Petersen F.
Blood. 2000 Feb 15;95(4):1158-66

1999

"Allergen engineering": variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity.

 
Schramm G, Kahlert H, Suck R, Weber B, Stuwe HT, Muller WD, Bufe A, Becker WM, Schlaak MW, Jager L, Cromwell O, Fiebig H.
J Immunol. 1999 Feb 15;162(4):2406-14

A nonspecific, single-stranded nuclease activity with characteristics of a topoisomerase found in a major grass pollen allergen: possible biological significance.

 
Bufe A, Uhlig U, Scholzen T, Matousek J, Schlaak M, Weber W.
Biol Chem. 1999 Jul-Aug;380(7-8):1009-16

Differential recognition of recombinant Phl p 5 isoallergens by Phl p 5-specific T cells.

 
van Neerven R, Wissenbach M, Ipsen H, Bufe A, Arnved J, Wurtzen PA.
>Int Arch Allergy Immunol. 1999 Feb-Apr;118(2-4):125-8

Early interleukin-4: its role in the switch towards a Th2 response and IgE-mediated allergy.

 
Haas H, Falcone FH, Holland MJ, Schramm G, Haisch K, Gibbs BF, Bufe A, Schlaak M.
Int Arch Allergy Immunol. 1999 Jun;119(2):86-94. Review.

Granulocyte-macrophage colony-stimulating factor modulates lipopolysaccharide (LPS)-binding and LPS-response of human macrophages: inverse regulation of tumour necrosis factor-alpha and interleukin-10.

 
Kreutz M, Hennemann B, Ackermann U, Grage-Griebenow E, Krause SW, Andreesen R.
Immunology. 1999 Dec;98(4):491-6

Highly heterogeneous Phl p 5-specific T cells from patients with allergic rhinitis differentially recognize recombinant Phl p 5 isoallergens.

 
Wurtzen P, Wissenbach M, Ipsen H, Bufe A, Arnved J, van Neerven RJ.
J Allergy Clin Immunol. 1999 Jul;104(1):115-22

Identification of isoform-specific T-cell epitopes in the major timothy grass pollen allergen, Phl p 5.

 
Wurtzen PA, Bufe A, Wissenbach M, Madsen HO, Ipsen H, Arnved J, Van Neerven RJ.
Clin Exp Allergy. 1999 Dec;29(12):1614-25

Monitoring allergen immunotherapy of pollen-allergic patients: the ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome.

 
Gehlhar K, Schlaak M, Becker W, Bufe A.
Clin Exp Allergy. 1999 Apr;29(4):497-506

Purification of morphologically and functionally intact human basophils to near homogeneity.

 
Haisch K, Gibbs BF, Korber H, Ernst M, Grage-Griebenow E, Schlaak M, Haas H.
J Immunol Methods. 1999 Jun 24;226(1-2):129-37

The role of cytokines in monocyte apoptosis.

 
Flad HD, Grage-Griebenow E, Petersen F, Scheuerer B, Brandt E, Baran J, Pryjma J, Ernst M.
Pathobiology. 1999;67(5-6):291-3. Review

1998

Allergenic activity of a major grass pollen allergen is elevated in the presence of nasal secretion.

 
Bufe A, Gehlhar K, Schramm G, Schlaak M, Becker WM.
Am J Respir Crit Care Med. 1998 Apr;157(4 Pt 1):1269-76

Apoptosis in monocytes.

 
Grage-Griebenow E, Durrbaum-Landmann I, Pryjma J, Loppnow H, Flad HD, Ernst M.
Eur Cytokine Netw. 1998 Dec;9(4):699-700

Induction of manganese superoxide dismutase gene expression in broncho-epithelial cells after exposure to mineral wool

 
Gillissen A, Jaworska M, Loseke S.
Pneumologie. 1998 Apr;52(4):188-9

Induction of manganese superoxide dismutase gene expression in bronchoepithelial cells after rockwool exposure.

 
Marks-Konczalik J, Gillissen A, Jaworska M, Loseke S, Voss B, Fisseler-Eckhoff A, Schmitz I, Schultze-Werninghaus G.
Lung. 1998;176(3):165-80

Molecular and immunological characterization of group V allergen isoforms from velvet grass pollen (Holcus lanatus).

  Schramm G, Bufe A, Petersen A, Schlaak M, Becker WM.
Eur J Biochem. 1998 Mar 1;252(2):200-6
 

Polymerase chain reaction-single strand conformation polymorphism or how to detect reliably and efficiently each sequence variation in many samples and many genes.

  Jaeckel S, Epplen JT, Kauth M, Miterski B, Tschentscher F, Epplen C.
Electrophoresis. 1998 Dec;19(18):3055-61. Review
 

The biological function of allergens: relevant for the induction of allergic diseases?

  Bufe A.
Int Arch Allergy Immunol. 1998 Dec;117(4):215-9. Review

The role of cytokines in monocyte apoptosis.

 
Flad HD, Grage-Griebenow E, Scheuerer B, Durrbaum-Landmann I, Petersen F, Brandt E, Fleischer J, Baran J, Pryjma J, Ernst M.
Res Immunol. 1998 Sep-Oct;149(7-8):733-6. Review

1997

An Fc gamma receptor I (CD64)-negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen-activated CD4-positive cytotoxic T cells.

  Grage-Griebenow E, Baran J, Loppnow H, Los M, Ernst M, Flad HD, Pryjma J.
Eur J Immunol. 1997 Sep;27(9):2358-65

Antiinflammatory and antifibrotic properties of colchicine: implications for idiopathic pulmonary fibrosis.

 
Entzian P, Schlaak M, Seitzer U, Bufe A, Acil Y, Zabel P.
Lung. 1997;175(1):41-51

Investigation of different recombinant isoforms of grass group-V allergens (timothy grass pollen) isolated by low-stringency cDNA hybridization-antibody binding capacity and allergenic activity.

 
Gehlhar K, Petersen A, Schramm G, Becker WM, Schlaak M, Bufe A.
Eur J Biochem. 1997 Jul 1;247(1):217-23

   
Mapping of IgE-binding epitopes on the recombinant major group I allergen of velvet grass pollen, rHol l 1.

  Schramm G, Bufe A, Petersen A, Haas H, Schlaak M, Becker WM.
J Allergy Clin Immunol. 1997 Jun;99(6 Pt 1):781-7

1996

Crystallization and preliminary diffraction data of a major pollen allergen. Crystal growth separates a low molecular weight form with elevated biological activity.

  Bufe A, Betzel C, Schramm G, Petersen A, Becker WM, Schlaak M, Perbandt M, Dauter Z, Weber W.
J Biol Chem. 1996 Nov 1;271(44):27193-6

Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes.

  Fleischer J, Soeth E, Reiling N, Grage-Griebenow E, Flad HD, Ernst M.
Immunology. 1996 Dec;89(4):592-8
 

Fc gamma receptor I (CD64)-negative human monocytes are potent accessory cells in viral antigen-induced T cell activation and exhibit high IFN-alpha-producing capacity.

  Grage-Griebenow E, Flad HD, Ernst M.
J Leukoc Biol. 1996 Sep;60(3):389-96
 

Group 5 allergens of timothy grass (Phl p 5) bear cross-reacting T cell epitopes with group 1 allergens of rye grass (Lol p 1).

  Muller WD, Karamfilov T, Bufe A, Fahlbush B, Wolf I, Jager L.
Int Arch Allergy Immunol. 1996 Apr;109(4):352-5
 

Identification and characterization of the major allergens of velvet grass (Holcus lanatus), Hol l 1 and Hol l 5.

 
Schramm G, Petersen A, Bufe A, Schlaak M, Becker WM.
Int Arch Allergy Immunol. 1996 Aug;110(4):354-63

Pathogenetic significance of IgE-binding epitopes allergens

 
Bufe A, Schramm G.
Pneumologie. 1996 Sep;50(9):625-31 Review. German

The function of allergens may determine allergenicity.

  Bufe A, Schramm G, Petersen A, Schlaak M, Becker WM.
Adv Exp Med Biol. 1996;409:399-402. Review

The major birch pollen allergen, Bet v 1, shows ribonuclease activity.

   Bufe A, Spangfort MD, Kahlert H, Schlaak M, Becker WM.
Planta. 1996;199(3):413-5
 

1995

Characterization of the allergen group VI in timothy grass pollen (Phl p 6). I. Immunological and biochemical studies.

 
Petersen A, Bufe A, Schlaak M, Becker WM.
Int Arch Allergy Immunol. 1995 Sep;108(1):49-54

Characterization of the allergen group VI in timothy grass pollen (Phl p 6). II. cDNA cloning of Phl p 6 and structural comparison to grass group V.

 
Petersen A, Bufe A, Schramm G, Schlaak M, Becker WM.
Int Arch Allergy Immunol. 1995 Sep;108(1):55-9

Major allergen Phl p Vb in timothy grass is a novel pollen RNase.

 
Bufe A, Schramm G, Keown MB, Schlaak M, Becker WM.
FEBS Lett. 1995 Apr 17;363(1-2):6-12

Molecular characterization of timothy grass pollen group V allergens.

 
Becker WM, Bufe A, Petersen A, Schlaak M.
Int Arch Allergy Immunol. 1995 May-Jun;107(1-3):242-4. Review

Structural investigations of the major allergen Phl p I on the complementary DNA and protein level.

  Petersen A, Schramm G, Bufe A, Schlaak M, Becker WM.
J Allergy Clin Immunol. 1995 May;95(5 Pt 1):987-94
 

1994

Major allergen Phl p Va (timothy grass) bears at least two different IgE-reactive epitopes.

   Bufe A, Becker WM, Schramm G, Petersen A, Mamat U, Schlaak M.
J Allergy Clin Immunol. 1994 Aug;94(2 Pt 1):173-81

1993

Phenotypical and functional characterization of Fc gamma receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity.

  Grage-Griebenow E, Lorenzen D, Fetting R, Flad HD, Ernst M.
Eur J Immunol. 1993 Dec;23(12):3126-35