References and literature
Research papers and review articles
Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2004). "Thyrotropic Feedback Control: Evidence for an Additional Ultrashort Feedback Loop from Fractal Analysis." Cybernetics and Systems 35 (4): 315-31. doi: 10.1080/01969720490443354
Dietrich JW, Landgrafe G, Fotiadou EH (2012). TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis. J Thyroid Res. 2012;2012:351864. doi: 10.1155/2012/351864. Epub 2012 Dec 30. PMID: 23365787; PMCID: PMC3544290.
Hoermann, R., J. E. M. Midgley, R. Larisch, J. W. Dietrich (2013). Is Pituitary Thyrotropin an Adequate Measure Of Thyroid Hormone-Controlled Homeostasis During Thyroxine Treatment?. European Journal of Endocrinology 168(2):271-80. PMID 23184912, doi: 10.1530/EJE-12-0819.
Midgley, J. E. M., R. Hoermann, R. Larisch, J. W. Dietrich (2013). Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model. Journal of Clinical Pathology 66(4):335-42. PMID 23423518, doi: 10.1136/jclinpath-2012-201213.
Hoermann R, Midgley JE, Larisch R, Dietrich JW (2015). Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Hormone and Metabolic Research, PMID: 25750078 doi: 10.1055/s-0034-1398616.
Dietrich JW, Müller P, Schiedat F, Schlömicher M, Strauch J, Chatzitomaris A, Klein HH, Mügge A, Köhrle J, Rijntjes E, Lehmphul I. Nonthyroidal Illness Syndrome in Cardiac Illness Involves Elevated Concentrations of 3,5-Diiodothyronine and Correlates with Atrial Remodeling. Eur Thyroid J. 2015 Jun;4(2):129-37. doi: 10.1159/000381543. Epub 2015 May 23. PMID 26279999; PMCID PMC4521060.
Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH, Midgley JE, Hoermann R. Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. PMID: 27375554; PMCID: PMC4899439.
Berberich J, Dietrich JW, Hoermann R, Müller MA. Mathematical Modeling of the Pituitary-Thyroid Feedback Loop: Role of a TSH-T(3)-Shunt and Sensitivity Analysis. Front Endocrinol (Lausanne). 2018 Mar 21;9:91. doi 10.3389/fendo.2018.00091. PMID 29619006; PMCID PMC5871688.
Hoermann R, Midgley JEM, Larisch R, Dietrich JW (2018). The role of functional thyroid capacity in pituitary thyroid feedback regulation. Eur J Clin Invest. 2018 Oct;48(10):e13003. doi: 10.1111/eci.13003. PMID: 30022470.
Aweimer A, El-Battrawy I, Akin I, Borggrefe M, Mügge A, Patsalis PC, Urban A, Kummer M, Vasileva S, Stachon A, Hering S, Dietrich JW. Abnormal thyroid function is common in takotsubo syndrome and depends on two distinct mechanisms: results of a multicentre observational study. J Intern Med. 2021 May;289(5):675-687. doi: 10.1111/joim.13189. Epub 2020 Nov 12. PMID: 33179374.
Aweimer A, Schiedat F, Schöne D, Landgrafe-Mende G, Bogossian H, Mügge A, Patsalis PC, Gotzmann M, Akin I, El-Battrawy I, Dietrich JW. Abnormal Cardiac Repolarization in Thyroid Diseases: Results of an Observational Study. Front Cardiovasc Med. 2021 Nov 23;8:738517. doi: 10.3389/fcvm.2021.738517. PMID: 34888359; PMCID: PMC8649843.
Dietrich JW, Dasgupta R, Anoop S, Jebasingh F, Kurian ME, Inbakumari M, Boehm BO, Thomas N. SPINA Carb: a simple mathematical model supporting fast in-vivo estimation of insulin sensitivity and beta cell function. Sci Rep. 2022 Oct 21;12(1):17659. doi: 10.1038/s41598-022-22531-3. PMID: 36271244; PMCID: PMC9587026.
Abu Rached N, Dietrich JW, Ocker L, Quast DR, Scheel C, Gambichler T, Bechara FG. Primary Thyroid Dysfunction Is Prevalent in Hidradenitis Suppurativa and Marked by a Signature of Hypothyroid Graves' Disease: A Case-Control Study. J Clin Med. 2023 Dec 4;12(23):7490. doi: 10.3390/jcm12237490. PMID: 38068542; PMCID: PMC10707714.
Bazika-Gerasch B, Kumowski N, Enax-Krumova E, Kaisler M, Eitner LB, Maier C, Dietrich JW. Impaired autonomic function and somatosensory disturbance in patients with treated autoimmune thyroiditis. Sci Rep. 2024 May 29;14(1):12358. doi: 10.1038/s41598-024-63158-w. PMID: 38811750; PMCID: PMC11137073.
Dietrich JW, Abood A, Dasgupta R, Anoop S, Jebasingh FK, Spurgeon R, Thomas N, Boehm BO. A novel simple disposition index (SPINA-DI) from fasting insulin and glucose concentration as a robust measure of carbohydrate homeostasis. J Diabetes. 2024 Sep;16(9):e13525. doi: 10.1111/1753-0407.13525. Epub 2024 Jan 2. PMID: 38169110; PMCID: PMC11418405.
Bansal V, Winkelmann BR, Dietrich JW, Boehm BO. Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene. Front Endocrinol (Lausanne). 2024 Feb 20;15:1258982. doi: 10.3389/fendo.2024.1258982. PMID: 38444585; PMCID: PMC10913019.
Aweimer A, Dietrich JW, Santoro F, Fàbregas MC, Mügge A, Núñez-Gil IJ, Vazirani R, Vedia O, Pätz T, Ragnatela I, Arcari L, Volpe M, Corbì-Pascual M, Martinez-Selles M, Almendro-Delia M, Sionis A, Uribarri A, Thiele H, Brunetti ND, Eitel I, Stiermaier T, Hamdani N, Abumayyaleh M, Akin I, El-Battrawy I. Takotsubo syndrome outcomes predicted by thyroid hormone signature: insights from cluster analysis of a multicentre registry. EBioMedicine. 2024 Apr;102:105063. doi: 10.1016/j.ebiom.2024.105063. Epub 2024 Mar 18. PMID: 38502972; PMCID: PMC10963195.
Dietrich, J. W., Siegmar, N., Hojjati, J. R., Gardt, O., & Boehm, B. O. (2024). CyberUnits Bricks: An Implementation Study of a Class Library for Simulating Nonlinear Biological Feedback Loops. ADCAIJ: Advances in Distributed Computing and Artificial Intelligence Journal, 13(1), e31762. doi: 10.14201/adcaij.31762
Dietrich JW, P4-Endokrinologie – Kybernetische Perspektiven eines neuen Ansatzes, Leibniz Online, Dez. 2024, doi: 10.53201/leibnizonline54.
Abu Rached N, Dietrich JW, Ocker L, Stockfleth E, Haven Y, Myszkowski D, Bechara FG. Endotyping Insulin-Glucose Homeostasis in Hidradenitis Suppurativa: The Impact of Diabetes Mellitus and Inflammation. J Clin Med. 2025 Mar 21;14(7):2145. doi: 10.3390/jcm14072145. PMID: 40217596; PMCID: PMC11990022.
Conference papers
Dietrich, J. W., U. Mitzdorf, R. Weitkunat und C. R. Pickardt (1997). "The pituitary-thyroid feedback control: stability and oscillations in a new nonlinear model." Journal of Endocrinological Investigation 20 (Suppl. to no. 5): 100.
Dietrich, J., M. Fischer, J. Jauch, E. Pantke, R. Gärtner und C. R. Pickardt (1999). "SPINA-THYR: A Novel Systems Theoretic Approach to Determine the Secretion Capacity of the Thyroid Gland." European Journal of Internal Medicine 10, Suppl. 1 (5/1999): S34.
Dietrich, J. W., A. Tesche, C. R. Pickardt und U. Mitzdorf (2002). Fractal Properties of the Thyrotropic Feedback Control: Implications of a Nonlinear Model Compared with Empirical Data. In: Cybernetics and Systems 2002. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies: 329-34.
Dietrich, J. W. and B. O. Boehm (2006). Equilibrium behaviour of feedback-coupled physiological saturation kinetics. In: Cybernetics and Systems 2006. R. Trappl (Hrsg). Vienna, Austrian Society for Cybernetic Studies. 1: 269-74. doi: 10.13140/2.1.2400.2568
Dietrich JW, Boehm BO: Die MiMe-NoCoDI-Plattform: Ein Ansatz für die Modellierung biologischer Regelkreise. GMS - German Medical Science 2015(60. Jahrestagung der GMDS e.V.): DocAbstr. 284.
Dietrich JW. A Methodology for Vertical Translation Between Molecular and Organismal Level in Biological Feedback Loops. bioRxiv 2021.09.20.461028; doi: 10.1101/2021.09.20.461028
Books
Dietrich JW. (2002). Der Hypophysen-Schilddrüsen-Regelkreis. Entwicklung und klinische Anwendung eines nichtlinearen Modells. Berlin, Logos-Verlag. ISBN 978-3-89722-850-4.
Dietrich JW, Midgley JEM, Hoermann R (2018), Homeostasis and allostasis of thyroid function. Lausanne: Frontiers Media, 2018. doi: 10.3389/978-2-88945-570-6
Hoermann R, Dietrich JW (2025), Hypothyroidism: a Paradigm Shift, Singapore: Springer Nature Singapore, 2025. doi: 10.1007/978-981-96-3682-2.
