Project A2 (Jancke)

Stability and plasticity of activity and specificity maps in early visual cortex

Summary

Bild für Projekt A2

We have demonstrated how systematic modulations of the cortical state can be used in combination with changes in input statistics (visual "training") to trigger targeted reorganization of visual cortical maps. We will next investigate how such induced plastic changes can be established through cortical integration processes in the context of behaviour. To capture intra- and cross-areal interactions across large populations of neurons we will use wide-field voltage- and Ca2+ imaging in transgenic mouse models. Our study has practical implications for perceptual learning and rehabilitation in traumatic or neurodegenerative impairment of the brain.