Faculty of chemistry and biochemistry » Workgroup Dr. Ebbinghaus


A biosensor-based framework to measure latent proteostasis capacity

R.J. Wood, A.R. Ormsby, M. Radwan, D. Cox, A. Sharma, T. Vöpel, S. Ebbinghaus, M. Oliveberg, G.E. Reid, A. Dickson, D.M. Hatters*
Nature Communications, 287, 2018

A multi-perspective approach to solvent regulation of enzymatic activity: HMG-CoA reductase

M. Dirkmann, J. Iglesias, V. Muñoz, P. Sokkar, C. Rumancev, A. von Gundlach, O. Krenczyk, T. Vöpel, J. Nowack, M.A. Schroer, S. Ebbinghaus, C. Herrmann, A. Rosenhahn, E. Sanchez-Garcia* and F. Schulz*
ChemBioChem, 19(2), 153-158, 2018

Imperfect crowding adaptation of mammalian cells towards osmotic stress and its modulation by osmolytes

D. Gnutt, O. Brylski, E. Edengeiser, M. Havenith, S. Ebbinghaus*
Molecular BioSystems, 13, 2218-21, 2017

Elucidation of the Catalytic Mechanism of a Miniature Zinc Finger Hydrolase

A. Ganguly, T. Luong, O. Brylski, M. Dirkmann, D. Möller, S. Ebbinghaus, F. Schulz, R. Winter, E. Sanchez-Garcia*, W. Thiel*
Journal of Physical Chemistry B, 21(26):6390–6398, 2017.

Inhibition of Huntingtin Exon‑1 Aggregation by the Molecular Tweezer CLR01

T. Vöpel, K. Bravo-Rodriguez, S. Mittal, S. Vachharajani, D. Gnutt, A. Sharma, A. Steinhof, O. Fatoba, G. Ellrichmann, M. Nshanian, C. Heid, J. A. Loo, F. G. Klärner, T. Schrader, G. Bitan, E. E. Wanker,
S. Ebbinghaus*, E. Sanchez-Garcia*
J. Am. Chem. Soc., 139(16):5640–5643, 2017.

Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells

S. Büning, A. Sharma, S. Vachharajani, E. Newcombe, A. Ormsby, M. Gao, D. Gnutt, T. Vöpel, D. M. Hatters, S. Ebbinghaus*
Phys. Chem. Chem. Phys., 19, 10738-10747, 2017.

Das Innere der Zelle: Ein komplexes Lösungsmittel

M. Heyden, S. Ebbinghaus, R. Winter
Chemie in unserer Zeit, 51(1), 26–33, 2017.

The Temperature Dependence of the Hofmeister Series: Thermodynamic Fingerprints of Cosolute-Protein Interactions

M. Senske, D. Constantinescu, M. Havenith, C. Herrmann*, H. Weingärtner, S. Ebbinghaus*
Phys. Chem. Chem. Phys., 18, 29698-29708, 2016.

RNA hairpin folding in the crowded cell

M. Gao#, D. Gnutt#, A. Orban, B. Appel, F. Righetti, R. Winter, F. Narberhaus, S. Müller, S. Ebbinghaus*
Angew. Chem. Int. Ed., 55(9):3224-8, 2016.

Press release

Faltung einer RNA-Haarnadel in der dicht gedrängten Zelle

M. Gao#, D. Gnutt#, A. Orban, B. Appel, F. Righetti, R. Winter, F. Narberhaus, S. Müller, S. Ebbinghaus*
Angew. Chem. Int. Ed., 128(9):3279–83, 2016.


Simultaneous measurements of photocurrents and H2O2 evolution from solvent exposed Photosystem 2 complexes

T. Vöpel, E.N. Saw, V. Hartmann, R. Williams, F. Müller, W. Schuhmann, N. Plumeré, M. Nowaczyk, S. Ebbinghaus*, M. Rögner*
Biointerphases, 11, 019001, 2016.

Vom Reagenzglas in die Zelle

D. Gnutt, M. Heyden* and S. Ebbinghaus*
Nachrichten aus der Chemie (Trendbericht Physikalische Chemie), 03/2016.

The macromolecular crowding effect – from in vitro into the cell

D. Gnutt and S. Ebbinghaus*
Biol. Chem., 397(1):37-44, 2016.

Protein stability in crowded environments

M. Senske, S. Ebbinghaus and C. Herrmann*
Book chapter in Biocalorimetry: Foundations and Contemporary Approaches
(Taylor & Francis), 13:241-253, 2016.

Infrared laser triggered release of bioactive compounds from single hard shell microcapsules

T. Vöpel, R. Scholz, L. Davico, M. Groß, S. Büning, S. Kareth, E. Weidner and S. Ebbinghaus*
Chem. Commun., 51, 6913-6916, 2015.

Selected for the Back Cover.

Excluded volume effects in the living cell

D. Gnutt, M. Gao, O. Brylski, M. Heyden and S. Ebbinghaus*
Angew. Chem. Int. Ed., 54(8):2548–51, 2015

Selected as "Hot Paper"
Press release

Effekte des Volumenausschlusses in lebenden Zellen

D. Gnutt, M. Gao, O. Brylski, M. Heyden and S. Ebbinghaus*
Angew. Chem., 127(8): 2578–81, 2015

Ausgezeichnet als "Hot Paper"

Modulation of human IAPP fibrillation: Cosolutes, crowders and chaperones

M. Gao, K. Estel, J. Seeliger, R.P. Friedrich, S. Dogan, E.E. Wanker, R. Winter and S. Ebbinghaus*
Phys. Chem. Chem. Phys., 17, 8338-48, 2015.

Selected for the Back Cover.

Non-invasive chemical assessment of living human spermatozoa

E. Edengeiser, K. Meister, E. Bründermann, S. Büning, S. Ebbinghaus, M. Havenith*
RSC Advances, (5), 10424-10429, 2015

Understanding the ‘native’ solvent – from the test tube into the cell

M. Senske, S. Büning and S. Ebbinghaus*
Bunsenmagazin, (6), 276–281, 2014.

Protein Stabilization by Macromolecular Crowding through Enthalpy rather than Entropy

M. Senske, L. Törk, B. Born, M. Havenith, C. Herrmann and S. Ebbinghaus*
J. Am. Chem. Soc., 136 (25), 9036–9041, 2014.

Press release: “Work environment” affects protein properties

Relaxationskinetik in lebenden Zellen

S. Büning, S. Ebbinghaus*
BIOspektrum, 20(4), 383-385, 2014.

Particle Dynamics Microscopy Using Temperature Jump and Probe Anticorrelation/Correlation Techniques.

M. Gruebele, S. Ebbinghaus, A. Dhar, J.D. McDonald
US patent 8,757,871, 2014

Probing solvation dynamics by THz absorption spectroscopy

B. Born, M. Heyden, S. Ebbinghaus and M. Havenith*
Terahertz Biomedical Science and Technology, CRC Press, 2014

Long-range protein-water dynamics in hyperactive insect antifreeze proteins

K. Meister, S. Ebbinghaus, Y. Xu, J.G. Duman, A.L. DeVries, M. Gruebele, D.M. Leitner and M. Havenith*
Proc. Nat. Acad. Sci. USA, 110(5):1617-1622, 2013.

"How An Insect Version Of Antifreeze Works" Veröffentlichung in Chemical & Engineering News

Functional Importance of Short-Range Binding and Long-Range Solvent Interactions in Helical Antifreeze Peptides

S. Ebbinghaus, K. Meister, M. B. Prigozhin, A. L. DeVries, M. Havenith, J. Dzubiella, and M. Gruebele*
Biophys. J., 103:20-22, 2012.

Protein Stability and Folding Kinetics in the Nucleus and Endoplasmic Reticulum of Eucaryotic Cells

A. Dhar, K. Girdhar, D. Singh, H. Gelman, S. Ebbinghaus, M. Gruebele*
Biophys. J., 101:1-10, 2011.

Protein Folding Landscapes in the Living Cell

S. Ebbinghaus and M. Gruebele*
J. Phys. Chem. Lett., 2:314-319, 2011.

Structure, function, and folding of phosphoglycerate kinase are strongly perturbed by macromolecular crowding

A. Dhar, A. Samiotakis, S. Ebbinghaus, L. Nienhaus, D. Homouz, M. Gruebele, M.S. Cheung*
Proc. Nat. Acad. Sci. USA, 107:17586-17591, 2010.

The diffusion coefficient for PGK folding in eukaryotic cells

A. Dhar#, S. Ebbinghaus#, Z. Shen, T. Mishra, M. Gruebele*
Biophys. J., 99:69-71, 2010.

Antifreeze glycoprotein activity correlates with long-range protein-water dynamics

S. Ebbinghaus, K. Meister, B. Born, A. L. DeVries, M. Gruebele and M. Havenith*
J. Am. Chem. Soc., 132:12210-12211, 2010.

Terahertz Spectroscopy as a Tool to Study Hydration Dynamics

M. Heyden, S. Ebbinghaus, M. Havenith*
Encyclopedia of Analytical Chemistry, Analytical Chemistry, eds R.A. Meyers, John Wiley: Chichester, 2010.

Protein folding stability and dynamics imaged in a living cell

S. Ebbinghaus, A. Dhar, J.D. McDonald and M. Gruebele*
Nature Methods, 7:319-323, 2010.

The terahertz dance of water with the proteins: the effect of protein flexibility on the dynamical hydration shell of ubiquitin

B. Born, S.J. Kim, S. Ebbinghaus, M. Gruebele, M. Havenith*
Faraday Discuss., 141:161-173, 2009.

Protein sequence- and pH-dependent hydration probed by Terahertz spectroscopy

S. Ebbinghaus, S.J. Kim, M. Heyden, X. Yu, M. Gruebele, D. Leitner and M. Havenith*
J. Am. Chem. Soc., 130:2374-2375, 2008.

An extended dynamical solvation shell around proteins

S. Ebbinghaus, S.J. Kim, M. Heyden, X. Yu, U. Heugen, M. Gruebele, D. Leitner and
M. Havenith*
Proc. Nat. Acad. Sci. USA, 104:20749-20752, 2007.

Terahertz time-domain spectroscopy as a new tool for the characterization of dust forming plasmas

S. Ebbinghaus, K. Schröck, J.C. Schauer, E. Bründermann, M. Heyden, G. Schwaab,
M. Böke, J. Winter, M. Tani and M. Havenith*
Plasma Sources Sci.Technol., 15:72-77, 2006.

Terahertz Imaging Applications in Spectroscopy of Biomolecules

E. Bründermann, U. Heugen, R. Schiwon, B. Born, G.W. Schwaab, S. Ebbinghaus, K.
Schröck, D.R. Chamberlin, E.E. Haller and M. Havenith*
Microwave Symposium Digest, IEEE MTT-SInternational:625-628, 2005.

High resolution spectroscopy of the ν3 band of DCOOD

F. Madeja, A. Hecker, S. Ebbinghaus and M. Havenith*
Spectrochimica Acta Part A, 59:1773, 2003.

High resolution spectroscopy of the ν3 band of the van der Waals complex Ar-DCOOH

F. Madeja, A. Hecker, S. Ebbinghaus and M. Havenith*
Mol. Phys., 101:1511, 2003.