Scientific Education
| 10/1989 – 9/1994 |
University Studies: Human biology
Philipps-University Marburg, Germany |
| 10/1991 – 1/1999 |
University Studies: Human medicine
Philipps-University Marburg, Germany |
| 11/1994 – 1/1999 |
PhD studies Human biology
Philipps-University Marburg, Germany
|
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University Examinations:
| 9/1991 |
Preliminary Examination in Human
biology |
| 3/1992 |
Preliminary Examination in Human
medicine |
| 9/1993 |
Final Examination in Human biology
(Diplom)
|
| 11/1999 |
Doctoral degree in Human biology (Dr.
rer. physiol.)
Philipps-University Marburg, Germany
|
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Research Experience:
| 8/1991 – 9/1993 |
Neurobiology group of Prof. Dr. K.
Unsicker;
Department of Anatomy and Cell biology, Philipps-University Marburg
Localisation and function of transforming growth factor betas in the
peripheral nervous system
|
| 10/1993 – 9/1994 |
Neuroendocrinology group of HD Dr. R.
Westermann;
Department of Anatomy and Cell biology, Philipps-University Marburg
Diploma thesis in Human biology:
‘Isolation and biological / biochemical characterisation of a high
molecular weight anti-FGF-2 immunoreactive protein’
|
| 11/1994 – 11/1998 |
Developmental Biology group of Prof.
Dr. R. Mirsky and Prof. Dr. K.R. Jessen;
Department of Anatomy and Developmental Biology, University College
London, UK
PhD thesis in Human biology:
‘Developmental regulation of survival and death in the Schwann cell
lineage: from paracrine signals to autocrine circuits’
|
| since 11/1998 |
Neuroanatomy and Molecular Brain
Research group of Prof. Dr. Dermietzel;
Department of Anatomy, Ruhr-University Bochum, Germany
|
| since
12/2002 |
Juniorprofessor for Experimental
Neurobiology
Localisation, function and inhibition of
gap junctions in the nervous system
|
| since 1/2003 |
Junior Research Group
Department of Anatomy, Ruhr-University Bochum, Germany
Therapeutical approaches for perinatal brain damage using umbilical
cord blood derived stem cells |
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Grants:
| 11/1994 – 5/1996 |
PhD Scholarship
German Academic Exchange Service, Bonn
|
| 7/1996 – 6/1998 |
Marie-Curie Fellowship / 'Training
and Mobility of Researchers'
European Union, Brussels
|
| 7/1999 |
Travelgrant Boehringer Ingelheim
Fonds
Research project at the laboratory of Prof. Dr. J. Rash, Colorado State
University, Fort Collins, USA |
| 8/2000 – 10/2000 |
Travelgrant Boehringer Ingelheim
Fonds
Continuation of the research project with Prof. Dr. J. Rash, Colorado
State University, Fort Collins, USA |
| 7/2000 – 7/2001 |
Research Grant FoRUM, Ruhr-Univeristy
Bochum |
| 8/2001 |
Travelgrant German Research
Foundation
Participation at the International Gap Junction Conference 2001 on the
Island of Hawaii, USA |
| 2002 |
Research Grant Junior Research Group
Stem Cell Network Northrhine Westfalia |
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Awards:
| 2000 |
Novartis-Preis
Novartis-Foundation and Philipps-University Marburg |
| 2004 |
Pfizer Forschungspreis
FoRUM Tagung 2004 |
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Research collaborations:
Prof. Dr.
John E. Rash
Dept. of Biological
Sciences,
Colorado State University, CO, USA
Prof. Dr.
Rhona Mirsky and Prof. Dr. Kristjàn Jessen
Dept. of Anatomy and
Developmental
Biology, University College London, UK
Prof. Dr.
K. Willecke
Institut
für Genetik, Universität Bonn
Prof. Dr.
A. Jensen
Klinik
für Gynäkologie und Geburtshilfe, Knappschaftskrankenhaus
Bochum-Langendreer
Prof. Dr. K. Überla
Abteilung für
Medizinische Virologie, Ruhr-Universität
Bochum
PD Dr. H.R. Dinse
Institut für
Neuroinformatik, Ruhr-Universität Bochum
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Publications
Journal
articles
(19)
C. Meier, J. Middelanis, B. Wasielewski, S. Neuhoff, A.
Roth-Härer, M.
Gantert, H.R. Dinse, R. Dermietzel und A. Jensen (2005) Functional
motor
recovery from perinatal hypoxic-ischemic brain damage after
intraperitoneal
transplantation of umbilical cord blood-derived mononuclear cells.
Submitted
for publication.
(18) K.
Striedinger, G. Zoidl, E. Petrasch-Parwez, M. Napirei, C.
Meier, U. Eysel und R. Dermietzel (2005) The neuronal connexin
Cx36 exhibits a neuroprotective effect in laser induced lesions of the
retina. Eur. J. Neurosci. Manuscript in press.
(17) J. Degen, C. Meier, R.S. van der
Giessen, G.
Sohl, E. Petrasch-Parwez, S. Urschel, R. Dermietzel, K. Schilling, C.I.
deZeuuw
and K. Willecke (2004) Expression pattern of lacZ reporter gene instead
of
connexin36 in conditional transgenic mice. J.
Comp.
Neurol. 473:
511-25.
(16)
C. Meier, R. Dermietzel, K.G.V. Davidson, T. Yasumura and J. Rash
(2004)
Cx32 containing gap junctions in Schwann cells at the internodal zone
of
partial compact myelin and in Schmidt-Lanterman incisures. J. Neurosci.
24:
3186-3198.
(15)
A. Jensen, H.M. Vaihinger und C. Meier
(2003) Perinatal brain damage – from neuroprotection to
neuroregeneration
using cord blood stem cells. Med. Klin. (Munich)
(2003) 98 Suppl. 2: 22-26.
(14) R. Dermietzel, C.
Meier, F. Bukauskas and D.C. Spray
(2003) Following tracks of hemichannels. Cell Commun. Adhes. 10:
335-340.
(13)
C.I. De Zeeuw, E. Chorev, A.
Devor, Y. Manor, R.S. Van Der Giessen, M.T. De Jeu, C.C. Hoogenraad, J.
Bijman,
T.J. Ruigrok, P. French, D. Jaarsma, W.M. Kistler, C.
Meier, E. Petrasch-Parwez, R. Dermietzel, G. Sohl, M.
Gueldenagel, K. Willecke and Y. Yarom (2003) Deformation of network
connectivity in the inferior olive of connexin 36-deficient mice is
compensated
by morphological and electrophysiological changes at the single neuron
level.
J. Neurosci. 23: 4700-4711.
(12)
K.R. Zahs, P. Kojuji, C. Meier and
R. Dermietzel (2003) Connexin
immunoreactivity in glial cells of the rat retina. J. Comp. Neurol.
455:
531-546.
(11) X. Li,
B.D. Lynn, C. Olson, C. Meier, K. Davidson, T.
Yasumura,
J.E. Rash and J.I Nagy (2002) Connexin29 expression in sciatic nerve,
co-localization with connexin32 and freeze-fracture immunogold
labelling at gap
junctions. Eur. J. Neurosci. 16: 795-806.
(10) C. Meier, E. Petrasch-Parwez, H.-W.
Habbes, B. Teubner, M.
Güldenagel, G. Söhl, J. Degen, K. Willecke and R. Dermietzel
(2002)
Immunohistochemical detection of the neuronal connexin36 in the mouse
central
nervous system in comparison to connexin36 deficient tissues.
Histochem. Cell
Biol. 117:461-471.
(9) G. Zoidl,
C. Meier, E. Petrasch-Parwez,
C. Zoidl, H.-W. Habbes, M. Kremer, M.
Srinivas, D.C. Spray and R. Dermietzel (2002) Evidence for a
role in subcellular localization of the
aminoterminal domain of the
neuronal connexin36 (Cx36). J. Neurosci. Res. (2002) 69:
448-465.
(8) R. Mirsky, K.R. Jessen, A.
Brennan, D. Parkinson, Z. Dong, C. Meier,
E. Parmantier and D. Lawson (2002) Schwann cells as regulators of nerve
development. J. Physiol. Paris 96: 17-24.
(7) D.B.
Parkinson, Z. Dong, H.
Bunting, J. Whitfield, C. Meier, H.
Marie, R. Mirsky and K.R. Jessen (2001) Transforming growth factor beta
(TGFß)
mediates Schwann cell death in vitro and in vivo: examination of c-Jun
activation, interactions with survival signals and the relationship of
TGFß-
mediated death to Schwann cell differentiation. J. Neuroscience 21:
8672-8585.
(6) R.
Mirsky, D.B. Parkinson, Z. Dong, C. Meier, E. Calle,
A. Brennan, P.
Topilko, B.S. Harris, H.J. Stewart and K.R. Jessen (2001) Regulation of
genes
involved in Schwann cell development and differentiation. Prog. Brain
Res.132:
3-11.
(5) C. Meier,
E. Parmantier, A. Brennan, R.
Mirsky and K.R. Jessen (1999) Developing Schwann cells acquire the
ability to
survive without axons by establishing an autocrine circuit involving
IGF, NT-3
and PDGF-BB. J. Neurosci. (1999) 19: 3847-3859.
(4) K.R. Jessen, C. Meier and
R. Mirsky (1999) Why do
Schwann cells survive in the absence of axons? Annals of the New York
Academy
of Sciences, Charcot-Marie-Tooth Disorders, Eds. M.E. Shy, J. Kamholz
und R.E.
Lovelace (1999) 883: 190-195.
(3) A.D.
Blanchard, A. Sinanan, E. Parmantier,
R. Zwart, L. Broos, D. Meijer, C. Meier, K. R. Jessen and R. Mirsky
(1996)
Oct-6 (SCIP/Tst-1) is expressed in Schwann cell precursors, embryonic
Schwann
cells and postnatal myelinating Schwann cells: comparison with Oct-1,
Krox-20
and Pax-3. J. Neurosci. Res. (1996) 46: 630-640.
(2) K.
Unsicker, C. Meier, K. Krieglstein, B.M. Sartor and
K.C. Flanders (1996)
Expression, Localization, and Function of Transforming growth
factors-ßs in the
Embryonic chick spinal cord, hindbrain and dorsal root ganglia. J.
Neurobiol.
(1996) 29: 262-276.
(1) K.
Unsicker, S. Engels, C. Hamm, G.
Lüdecke, C. Meier, J. Renzing, H.G.
Terbrack and K. Flanders (1992) Molecular control of neural plasticity
by the
multifunctional growth factor families of FGFs and TGF-betas. Ann.
Anat. (1992)
174: 405-407.
Book chapters
R. Dermietzel and C. Meier (2005) Gap Junction
Expression in brain tissues with focus on development. Gap Junctions in
Development and Disease, Springer Verlag, Ed. E. Winter-hager, in press.
Abstracts:
J
Li, J Eiberger, K Willecke, R Dermietzel and C
Meier (2005) Connexin expression during Schwann cell development in the
mouse.
International Gap Junction Conference, Whistler, CA
C Meier, J Middelanis, B
Wasielewski, M Gantert, A Roth-Haerer, S Neuhoff, H-M Vaihinger, HR
Dinse, R
Dermietzel, A Jensen (2005) Transplantation humaner Nabelschnurzellen
in neonatale
Ratten mit ischämischem Hirnschaden: “Homing” und
Funktionsverbesserung.
Niederrheinisch-Westfälische
Gesellschaft für Gynäkologie und Geburtshilfe, Düsseldorf
S Neuhoff, H-M Vaihinger, A
Jensen, C Meier (2005) In vitro Differenzierung neuraler Zellen aus
humanem
Nabelschnurblut. Niederrheinisch-Westfälische Gesellschaft
für Gynäkologie und
Geburtshilfe, Düsseldorf
S Neuhoff, H-M Vaihinger, A
Jensen, C Meier (2005) In vitro Differenzierung neuronaler und glialer
Zellen
aus humanem Nabelschnurblut. Archives
of Gynecology and Obstetrics 270, Suppl. 1: PO-G 17.8
C Meier, J Middelanis, B
Wasielewski, M Gantert, A Roth-Haerer, S Neuhoff, H-M Vaihinger, HR
Dinse, R
Dermietzel, A Jensen (2005) Transplantation und “Homing” humaner
Nabelschnurzellen in neonatalen Ratten mit ischämischem
Hirnschaden. Archives of Gynecology and
Obstetrics 270, Suppl. 1: PO-G 21.3
C Meier, J
Middelanis, B Wasielewski, M
Gantert, A Roth-Haerer, S Neuhoff, H-M Vaihinger, HR Dinse, R
Dermietzel, A Jensen
(2004) Human umbilical cord blood-derived cells in the treatment of
hypoxic-ischemic insults of the nervous system. Annals of Anatomy 186
Suppl.:
52
C Meier, J Middelanis,
B Wasielewski, M Gantert, A Roth-Haerer, S Neuhoff, H-M Vaihinger, HR
Dinse, A
Jensen (2004) Successful transplantation and homing of umbilical cord
blood
cells in neonatal rats after cerebral ischemia. Journal of the Society
for
Gynecologic Investigation 11, Number 2 (Suppl.): 349.
S
Neuhoff,
H-M Vaihinger, A Jensen, C Meier (2005) In vitro differentiation of
neuron- and
glia-like cells from human umbilical cord blood. Journal of the Society
for
Gynecologic Investigation 11, Number 2 (Suppl.): 59.
C Meier, J
Middelanis, B Wasielewski, M Gantert, A Roth-Härer, S Neuhoff, H-M
Vaihinger,
HR Dinse, R Dermietzel, A Jensen (2004) Successful transplantation and
homing
of human umbilical cord mononuclear blood cells in neonatal rats after
cerebral
ischemia. Abstractband des '2nd International Meeting Stem Cell Network
North
Rhine Westphalia' 01.-02.04.2004 in Bonn-Bad Godesberg.
J
Middelanis, B Wasielewski, M Gantert, A Roth-Haerer, S Neuhoff,
HR Dinse, A Jensen, C Meier (2003) Stammzellen aus Nabelschnurblut in
der
Therapie traumatischer und hypoxisch-ischämischer Verletzungen des
Nervensystems. Abstract auf der Internen Klausurtagung des
Kompetenznetzwerks
Stammzellforschung NRW, Hagen.
C Meier, T
Khayal and R Dermietzel (2002) Inhibition of glial connexins by
Cx43-mimetic
peptides. Annals of Anatomy 185, Suppl. (2002), Ed. W. Kühnel,
Abstr. 100.
T Khayal, C Meier and R Dermietzel (2002) Inhibition
of connexin 43 (Cx43) gap junctional activity by homophilic peptides.
Federation
of European Neuroscience Societies, Paris (2002) Abstr. 182.16
C
Meier, R Dermietzel, T Yasumura and JE
Rash (2002) Connexin Identification and Ultrastructural Localization of
Gap
Junctions: a novel site of Cx32 expression in Schwann cells. Federation of European Neuroscience
Societies, Paris (2002) Abstr. 182.20
C Meier, A Stang, H-W Habbes and R Dermietzel
(2002) Developmental and circadian expression of the gap junction
proteins
connexin 43 and connexin 36 in the rat retina. Annals of Anatomy 184,
Suppl.
(2002), Ed. W. Kühnel, 48.
C Meier, R Dermietzel, T Yasumura and JE Rash
(2001) Ultrastructural Localization and Connexin Identification of Gap
Junctions: A novel site of Cx32 expression in Schwann cells. International
Gap junction Conference 2001, Hawaii, USA
G
Zoidl, C
Meier, E Petrasch-Parwez, C Zoidl, M Kremer, DJ Spray and R Dermietzel
(2001) Subcellular
localization of the neuronal connexin 36 (Cx36) is determined by a
carboxyterminal PKA/CamKII phosphorylation site. The Neurosciences at
the Turn
of the Century', Proceedings of the 4th meeting of the
German
Neuroscience Society 2001, Eds. N. Elsner and G.W. Kreutzberg, Abstract
74
G Zoidl, C Meier, E
Petrasch-Parwez, C Zoidl, HW Habbes, D Spray und R Dermietzel (2001)
Funktionelle
Eigenschaften und subzelluläre Lokalisation des Gap
Junction-Proteins Cx36. Annals of Anatomy
183, Suppl., Ed.
W. Kühnel, 173-174.
C Meier, JE Rash, T Yasumura and R Dermietzel
(2001) Ultrastructural Localization and Connexin Identification of Gap
Junctions in Schwann cells. Annals of Anatomy 183, Suppl. (2001), Ed.
W.
Kühnel, Abstract 69.
E Parmantier,
C Meier, G Zoidl, M Turmaine, AP
McMahon, KR Jessen and R Mirsky (1998) Involvement of the signalling
molecule
desert hedgehog in peripheral nerve development. European meeting
on glial cell function in health and disease. Dialogue between glia and
neurons.
(1998) Abstract 023.
Z Dong, A Buttress, H Bunting, C Meier, R
Mirsky and KR Jessen (1998) TGF-ß regulates Schwann cell
survival. European
meeting on glial cell function in health and disease. Dialogue between
glia and
neurons. (1998) Abstract 177.
C Meier, E
Parmantier, A Brennan, R Mirsky and
KR Jessen (1998) Developmental regulation of survival in the Schwann
cell
lineage. European meeting on glial cell function in health and disease.
Dialogue between glia and neurons. (1998) Abstract 178.
C Meier, E Parmantier, A Brennan, R Mirsky and
KR Jessen (1998) Developmental regulation of Schwann cell survival
involves the
emergence of autocrine loops. Soc. of Neurosci. (1998) Abstract 27.5.
E Parmantier,
C Meier, G Zoidl, M Turmaine, AP
McMahon, KR Jessen and R Mirsky (1997) Desert Hedgehog is involved in
peripheral nerve development. ”Functions of glial cells”, Final
Symposium of
the DFG Study group, Abstract 118.
C Meier, E Parmantier, A Brennan, R Mirsky and
KR Jessen (1997) Developmental regulation of survival in the Schwann
cell lineage.
”Functions of glial cells”, Final Symposium of the DFG Study group,
(1997),
Abstract 106.
K Unsicker, C
Meier and KC Flanders (1994) Expression
and function of TGF-beta 2 and -beta 3 in the embryonic chick spinal
cord,
hindbrain and spinal ganglia. Abstracts Soc. Neuroscience (1994) Vol. 20
C
Meier, S Engels and R Westermann (1994) Purification
and biological activities of a high molecular weight
anti-bFGF-immunoreactive
protein. in: Sensoric Transduction; eds. Elsner and Beer, Thieme Verlag
Stuttgart: 911.
C Meier, K
Flanders, S Jakowlew, S Marascalco
and K Unsicker (1994) Expression of TGF -beta in developing sensory
ganglia and
peripheral nerve fibre tracts; evidence that TGF-ß stimulates
neurite
outgrowth. Ann. Anat. (1994) 176: 134-135.
C Meier, HG
Terbrack and K Unsicker (1994)
Localisation and in vitro effects of
TGF-ßs in the developing peripheral nervous system. Eur. J. Cell
Biol. (1994)
63 (Suppl. 40): 37.
C Meier, HG
Terbrack and K Unsicker (1993) TGF-beta
1,2 and 3 enhance neurite length and number on cultured sensory
neurons. in:
Gene, brain, behaviour; eds. Elsner and Heisenberg, Thieme Verlag Stuttgart, (1993): 620.
C.Meier,
H.G. Terbrack and K. Unsicker (1993) TGF-beta 1,2 and 3 regulate
neurite growth
in vitro. J. Neurochem. (1993)
61
(Suppl.), 165.
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