It is now possible to characterize brain cells, such as neurons and glial cells at the molecular level. Therefore we combine Laser microdissection with mass spectrometric analysis. This enables researchers to more closely examine brain cell-specific molecular pathways to elucidate distinct brain functions. Furthermore, the analysis of neuronal maintenance and disease-causing effects is a central component of neurological investigations.
Moreover, there is growing evidence that progression of neurodegenerative disorders activates the immune system and reduces its self-tolerance as becomes obvious from the appearance of autoimmune antibodies. It is both of scientific and medical interest to study these autoimmune responses and to characterize autoantigenes, if they can be used as disease markers.