Prof. Dr. Thomas Müller, Neurologische Universitätsklinik, St. Josef Hospital, Faculty of Medicine
Research Programme:
Use of various functional, morphologic brain imaging techniques (MRI, fMRI, SPECT, PET) in the diagnosis and evaluation of progression of neurodegenerative disorders, i.e. Parkinson's disease, in cooperation with the Department of Nuclear medicine, University of Essen, Department of Radiology, St. Josef Hospital, University of Bochum and the Department of Radiochemistry of the Forschungszentrum Jülich GmbH in combination with various simple instrumental tools.
Performance of neuropharmacological trials with putative neuroprotective or neurodegenerative compounds in neurodegenerative disease at least partially in close cooperation with the pharmaceutical industry.
Investigations of neuroophthalmologic changes in neurodegenerative disorders and the impact of dopaminergic compounds on visual function.
Studies on the pathogenesis of Parkinson's disease, dystonia, Huntington's disease, vascular brain disease and dementia with search for genetic, metabolic and environmental biomarkers and risk factors for neurodegenerative diseases in cooperation with the Department of Neuropharmacology (BMFT) (University of Berlin), Department of Neurochemistry (University of Würzburg), Department of Human Genetics (University of Bochum), Department of Neurology (University of Ulm).
Performance of epidemiologic, pharmacokinetic and pharmacologic trials on the efficacy of antiparkinsonian agents.
Research on neuropsychological changes in neurodegenerative diseases in cooperation of the Department of Neuropsychology (DFG) (University of Bochum).
Development and use of instrumental procedures and various reaction time paradigms for the evaluation of drug response in Parkinson's disease.
Research on levodopa induced vascular risk factors in neurodegenerative diseases with specific evaluation of genetic polymorphisms of drug metabolizing enzymes.
Evaluation of the clinical efficacy of intrathecally administered steroid preparation in the treatment of progressive multiple sclerosis with predominant spinal symptoms.
Studies on fine motor skills and control in Parkinson 's disease and related movement disorders.
Neurocognitive Mechanisms of Reward-Based Learning.
Implications for Basal Ganglia and Prefrontal Dysfunction
Th. Müller Project IV: Neurology