Publikationen

2012

A bioassay for determinaton of lipopolysaccharide in environmental samples

2011

Vom Stallstaub zum Molekül: Mechanismen der allergieprotektiven Wirkung

Arabinogalactan isolted from grass protects from allergic disease

Flow cytometry confirms reticulate evolution and reveals triploidy in Central European Diphasiastrum taxa (Lycopodiaceae, Lycophyta).

Design and Recruitment for the GAP Trail, Investigating the Preventive Effect on Asthma Development of an SQ-Standardized Grass Allergy Immunotherapy Tablet in Children with Grass Pollen-Induced Allergic Rhinoconjunctivitis

Indications and evidence base for specific immunotherapy in childhood.

Comparison of metabolites in exhaled breath and bronchoalveolar lavage fluid samples in a mouse model of asthma.

Specific immunotherapy in children.

Anti-inflammatory modulation of immune response by probiotic Escherichia coli Nissle 1917 in human blood mononuclear cells.

2010

Unifying Candidate Gene and GWAS Approaches in Asthma

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.

Conference Scene: Summary report from EAACI: London 2010.

T-cell polarization depends on concentration of the danger signal used to activate dendritic cells

Diagnostic value of outcome measures following allergen exposure in an environmental challenge chamber compared with natural conditions

Viral colonization in intubated patients: initial pathogen pattern and follow-up

Analyses of mouse breath with ion mobility spectrometry: a feasibility study

2009

Safety and efficacy in children of an SQ-standardised grass allergen tablet for sublingual immunotherapy.

2008

Modulation of dendritic cell function by cowshed dust extract.

Inflammatory Response in Acute Viral Exacerbations of COPD.

Animal shed Bacillus licheniformis spores possess allergy-protective as well as inflammatory properties

Wie funktioniert eigentlich die sublinguale Immuntherapie?

2007

Safety of Specific Sublingual Immunotherapy with SQ Standardised Grass Allergen Tablets in Children

Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma

Acinetobacter lwoffii and Lactococcus lactis strains isolated from farm cowsheds possess strong allergy-protective properties.

Anti-BDCA-4 (neuropilin-1) antibody can suppress virus-induced IFN-alpha production of plasmacytoid dendritic cells.

Synergistically upregulated interleukin-10 production in cocultures of monocytes and T cells after stimulation with respiratory syncytial virus.

2006

Clinical index-score and the ALMA study.

Impaired virus-induced interferon-alpha2 release in adult asthmatic patients.

In vitro allergy diagnosis. Guideline of the German Society of Asthma and Immunology in conjunction with the German Society of Dermatology

In vitro-generated viral double-stranded RNA in contrast to polyinosinic:polycytidylic acid induces interferon-alpha in human plasmacytoid dendritic cells.

Inhalation of stable dust extract prevents allergen induced airway inflammation and hyperresponsiveness.

Lysine as a critical amino acid for IgE binding in Phl p 5b C terminus.

The biological effects of syngeneic and allogeneic cytokine-expressing prophylactic whole cell vaccines and the influence of irradiation in a murine melanoma model.

2005

Association of interleukin-8 receptor alpha polymorphisms with chronic obstructive pulmonary disease and asthma.

Characterization of modified allergen extracts by in vitro beta-hexosaminidase release from rat basophils.

   
Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease.

Relevance of human metapneumovirus in exacerbations of COPD.

2004

Efficacy of sublingual swallow immunotherapy in children with severe grass pollen allergic symptoms: a double-blind placebo-controlled study.

Evaluation of a real-time polymerase-chain reaction for severe acute respiratory syndrome (SARS) associated coronavirus in patients with hospitalised exacerbation of COPD.

LPS-binding protein as a target molecule in allergy and asthma.

Microbial exposure of rural school children, as assessed by levels of N-acetyl-muramic acid in house dust, and its influence on respiratory health.

2003

Differential expression of IFN-alpha subtypes in human PBMC: evaluation of novel real-time PCR assays.

Evaluation of a quantitative real-time PCR for the detection of respiratory syncytial virus in pulmonary diseases.

Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study.

2002

Atopic phenotype in children is associated with decreased virus-induced interferon-alpha release.

Environmental exposure to endotoxin and its relation to asthma in school-age children.

Expression of CD14 and toll-like receptor 2 in farmers and 'non-farmers' children.

Structure of the functional domain of the major grass-pollen allergen Phl p 5b.

2001

Discontinuous IgE-binding epitopes contain multiple continuous epitope regions: results of an epitope mapping on recombinant Hol l 5, a major allergen from velvet grass pollen.

Heterogeneity of human peripheral blood monocyte subsets.

Identification of a novel dendritic cell-like subset of CD64(+) / CD16(+) blood monocytes.

Significance of IgE-binding epitopes in allergic disease.

2000

A human monoclonal IgE antibody defines a highly allergenic fragment of the major timothy grass pollen allergen, Phl p 5: molecular, immunological, and structural characterization of the epitope-containing domain.

   A simple advice for the prevention of pollen-induced allergic rhinitis.

Human MO subsets as defined by expression of CD64 and CD16 differ in phagocytic activity and generation of oxygen intermediates.

 T cell reactivity with allergoids: influence of the type of APC.

The CXC-chemokine platelet factor 4 promotes monocyte survival and induces monocyte differentiation into macrophages.

1999

"Allergen engineering": variants of the timothy grass pollen allergen Phl p 5b with reduced IgE-binding capacity but conserved T cell reactivity.

A nonspecific, single-stranded nuclease activity with characteristics of a topoisomerase found in a major grass pollen allergen: possible biological significance.

Differential recognition of recombinant Phl p 5 isoallergens by Phl p 5-specific T cells.

Early interleukin-4: its role in the switch towards a Th2 response and IgE-mediated allergy.

Granulocyte-macrophage colony-stimulating factor modulates lipopolysaccharide (LPS)-binding and LPS-response of human macrophages: inverse regulation of tumour necrosis factor-alpha and interleukin-10.

Highly heterogeneous Phl p 5-specific T cells from patients with allergic rhinitis differentially recognize recombinant Phl p 5 isoallergens.

Identification of isoform-specific T-cell epitopes in the major timothy grass pollen allergen, Phl p 5.

Monitoring allergen immunotherapy of pollen-allergic patients: the ratio of allergen-specific IgG4 to IgG1 correlates with clinical outcome.

Purification of morphologically and functionally intact human basophils to near homogeneity.

The role of cytokines in monocyte apoptosis.

1998

Allergenic activity of a major grass pollen allergen is elevated in the presence of nasal secretion.

Apoptosis in monocytes.

Induction of manganese superoxide dismutase gene expression in broncho-epithelial cells after exposure to mineral wool

Induction of manganese superoxide dismutase gene expression in bronchoepithelial cells after rockwool exposure.

Molecular and immunological characterization of group V allergen isoforms from velvet grass pollen (Holcus lanatus).

Polymerase chain reaction-single strand conformation polymorphism or how to detect reliably and efficiently each sequence variation in many samples and many genes.

The biological function of allergens: relevant for the induction of allergic diseases?

The role of cytokines in monocyte apoptosis.

1997

An Fc gamma receptor I (CD64)-negative subpopulation of human peripheral blood monocytes is resistant to killing by antigen-activated CD4-positive cytotoxic T cells.

Antiinflammatory and antifibrotic properties of colchicine: implications for idiopathic pulmonary fibrosis.

Investigation of different recombinant isoforms of grass group-V allergens (timothy grass pollen) isolated by low-stringency cDNA hybridization-antibody binding capacity and allergenic activity.

   
Mapping of IgE-binding epitopes on the recombinant major group I allergen of velvet grass pollen, rHol l 1.

1996

Crystallization and preliminary diffraction data of a major pollen allergen. Crystal growth separates a low molecular weight form with elevated biological activity.

Differential expression and function of CD80 (B7-1) and CD86 (B7-2) on human peripheral blood monocytes.

Fc gamma receptor I (CD64)-negative human monocytes are potent accessory cells in viral antigen-induced T cell activation and exhibit high IFN-alpha-producing capacity.

Group 5 allergens of timothy grass (Phl p 5) bear cross-reacting T cell epitopes with group 1 allergens of rye grass (Lol p 1).

Identification and characterization of the major allergens of velvet grass (Holcus lanatus), Hol l 1 and Hol l 5.

Pathogenetic significance of IgE-binding epitopes allergens

The function of allergens may determine allergenicity.

The major birch pollen allergen, Bet v 1, shows ribonuclease activity.

1995

Characterization of the allergen group VI in timothy grass pollen (Phl p 6). I. Immunological and biochemical studies.

Characterization of the allergen group VI in timothy grass pollen (Phl p 6). II. cDNA cloning of Phl p 6 and structural comparison to grass group V.

Major allergen Phl p Vb in timothy grass is a novel pollen RNase.

Molecular characterization of timothy grass pollen group V allergens.

Structural investigations of the major allergen Phl p I on the complementary DNA and protein level.

1994

Major allergen Phl p Va (timothy grass) bears at least two different IgE-reactive epitopes.

1993

Phenotypical and functional characterization of Fc gamma receptor I (CD64)-negative monocytes, a minor human monocyte subpopulation with high accessory and antiviral activity.