DFG-Forschergruppe 630

Biologische Funktion von Organometallverbindungen
Biological function of organometallic compounds

Kooperationen 2009

  • R. Bieda, I. Ott, R. Gust, W. S. Sheldrick
    Cytotoxic rhodium(III) polypyridyl complexes containing the tris(pyrazolyl)methane coligand: synthesis, DNA binding properties and structure-activity relationships
    Eur. J. Inorg. Chem., accepted for publication.
  • I. Ott, X. Qian, Y. Xu, D.H.W. Vlecken, I.J. Marques, D. Kubutat, J. Will, W. S. Sheldrick, P. Jesse, A. Prokop, C.P. Bagowski
    A Gold(I) Phosphine Complex Containing Naphthalimide Ligand Functions as a TrxR Inhibiting Antiproliferative Agent and Angiogenesis Inhibitor
    J. Med. Chem., accepted for publication
  • C. Walther, I. Ott, R. Gust, I. Neundorf
    Specific labeling with potent radiolabels alters the uptake of cell-penetrating peptides
    Biopolymers, in print
  • R. Bieda, I. Ott, M. Dobroschke, A. Prokop, R. Gust, W. S. Sheldrick
    Structure-activity relationships and DNA binding properties of apoptosis inducing cytotoxic rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS3
    J. Inorg. Biochem. 103 (2009) 698-708
  • M. Dobroschke, Y. Geldmacher, I. Ott, M. Harlos, L. Kater, L. Wagner, R. Gust, W. S. Sheldrick, A. Prokop
    Cytotoxic Rhodium(III) and Iridium(III) Polypyridyl Complexes: Structure-Activity Relationships, Antileukemic Activity and Apoptosis Induction
    ChemMedChem 4 (2009) 177-187.
  • F. Noor, R. Kinscherf, G.A. Bonaterra, S. Walczak, S. Wölfl, N. Metzler-Nolte
    Enhanced Cellular Uptake and Cytotoxicity Studies of Organometallic Bioconjugates of the NLS Peptide in Hep G2 Cells
    ChemBioChem 10 (2009) 493-502.
  • I. Ott, X. Qian, Y. Xu, D. Kubutat, J. Will, W. S. Sheldrick, P. Jesse, A. Prokop, C. Bagowski
    A gold(I) phosphine complex containing naphthalimide ligand functions as a TrxR inhibiting antiproliferative agent and angiogenesis inhibitor
    J. Med. Chem. 52 (2009) 763-770.
  • A. Hunold, I. Neundorf, P. James, J. Neudörfl, H.-G. Schmalz
    Stereoselective Synthesis of new Ferrocene-derived Amino Acid Building Blocks
    Eur. J. Org. Chem. (2009) 4429-4440.
  • A. Hille, I. Ott, A. Kitanovic, I. Kitanovic, H. Alborzina, E. Lederer, S. Wölfl, N. Metzler-Nolte, S. Schäfer, W.S. Sheldrick, C. Bischof, U. Schatzschneider, R. Gust
    [N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties
    J. Biol. Inorg. Chem. 14, 711-725 (2009)
  • H.W. Peindy N'Dongo, I. Ott, R. Gust, U. Schatzschneider
    Microwave-assisted solid-phase synthesis, cellular uptake, and cytotoxicity studies of cymantrene-peptide bioconjugates
    J. Organomet. Chem. 694 (2009) 823-827
  • I. Ott, B. Kircher, C.P. Bagowski, D.H.W. Vlecken, E.B. Ott, J. Will, K. Bensdorf, W. S. Sheldrick, R. Gust
    Modulation of the Biological Properties of Aspirin by Bioorganometallic Derivatisation
    Angew. Chem. Int. Ed. 48 (2009) 1160-1163.

Kooperationen 2008

  • M. A. Scharwitz, I. Ott, Y. Geldmacher, R. Gust, W. S. Sheldrick
    Cytotoxic half-sandwich rhodium(III) complexes: polypyridyl ligand influence on their DNA binding properties and cellular uptake
    J. Organomet. Chem. 693 (2008) 2299 - 2309.
  • M. A. Scharwitz, I. Ott, R. Gust, A. Kromm, W. S. Sheldrick
    Synthesis, cellular uptake and structure-activity relationships for potent cytotoxic trichlorididoiridium(III) polypyridyl complexes
    J. Inorg. Biochem. 102 (2008) 1623 - 1630.
  • I. Ott, M. Scharwitz, H. Scheffler, W. S. Sheldrick, R. Gust
    Atomic absorption spectrometric determination of the iridium content of tumor cells exposed to an iridium metallodrug
    J. Pharm. Biomed. Anal. 47 (2008) 938 - 942.
  • I. Neundorf, J. Hoyer, K. Splith, R. Rennert, H.W. Peindy N'Dongo, U. Schatzschneider
    Cymantrene conjugation modulates the intracellular distribution and induces high cytotoxicity of a cell-penetrating peptide
    Chem. Commun. (2008) 5604-5606
  • H.W. Peindy N'Dongo, I. Neundorf, K. Merz, U. Schatzschneider
    Synthesis, characterization, and X-ray crystallography of cymantrene keto carboxylic acids for IR labelling of bioactive peptides on a solid support
    J. Inorg. Biochem. 102 (2008) 2114-2119
  • M. Harlos, I. Ott, R. Gust, H. Alborzinia, S. Wölfl, A. Kromm, W. S. Sheldrick
    Synthesis, biological activity and structure activity relationships for potent cytotoxic rhodium (III) polypyridyl complexes
    J. Med. Chem. 51 (2008) 3924-3933
  • U. Schatzschneider, J. Niesel, I. Ott, R. Gust, H. Alborzinia, S. Wölfl
    Cellular Uptake, Cytotoxicity, and Metabolic Profiling of Ruthenium(II) Polypyridyl Complexes [Ru(bpy)2(N-N)]Cl2 with N-N = bpy, phen, dpq, dppz, and dppn
    ChemMedChem 3 (2008) 1104-1109
  • S. I. Kirin, I. Ott, R. Gust, W. Mier, T. Weyhermüller, N. Metzler-Nolte
    Cellular uptake quantification of metallated peptide and peptide nucleic acid bioconjugates by atomic absorption spectroscopy
    Angew. Chem. Int. Ed. (2008), 47, 955-959; Angew. Chem. (2008), 120, 969-973
  • J. Niesel, A. Pinto, H.W. Peindy N'Dongo, K. Merz, I. Ott, R. Gust, U. Schatzschneider
    Photoinduced CO release, cellular uptake, and cytotoxicity of a tris(pyrazolyl)methane manganese tricarbonyl complex
    Chem. Commun. (2008) 1798-1800

Kooperationen 2007

  • S. Schäfer, I. Ott, R. Gust, W. S. Sheldrick
    Influence of the polypyridyl (pp) ligand size on the DNA binding properties, cytotoxicity and cellular uptake of organoruthenium(II) complexes of the types [(η6-C6Me6)Ru(L)(pp)]n+ (L=Cl, n=1; L= (NH2)2CS, n=2)
    Eur. J. Inorg. Chem. (2007) 3034-3046

Kooperationen 2006

  • S.I. Kirin, U. Schatzschneider, X. de Hatten, T. Weyhermüller, N. Metzler-Nolte
    1,n'-Disubstituted ferrocenoyl amino acids and dipeptides: Conformational analysis by CD spectroscopy, X-ray crystallography, and DFT calculations
    J. Organomet. Chem. 691 (2006) 3451-3457