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10: e1003950. doi:10.1371/journal.ppat.1003950

Bloemendal S, Löper D, Terfehr D, Kopke K, Kluge J, Teichert I, Kück U (2014) Tools for advanced and targeted genetic manipulation of ß-lactam antibiotic producer Acremonium chrysogenum. J Biotech 169: 51-62


Kopke K, Hoff B, Bloemendal S, Katschorowski A, Kamerewerd J, Kück U (2013) Members of the Penicillium chrysogenum velvet complex play functionally opposing roles in the regulation of penicillin biosynthesis and conidiation. Eukaryot Cell 12: 299-310 PDF

Kamerewerd J, Zadra I, Kürnsteiner H, Kück U (2011) PcchiBI, encoding a class V chitinase,  is affected by PcVelA and PcLaeA and resobsible for cell wall integrity in Penicillium chrysogenum. Microbiology 157: 3036-3048  

Pöggeler S, O' Gorman C, Hoff B, Kück U (2011) Molecular organization of the mating-type loci in the homothallic Ascomycete Eupenicillium crustaceum. Fungal Biology 115: 615-624

Kück U (2011) Recombinant fungal biotechnology. McGraw Hill Encyclopedia of Science & Technology (in press)

Hoff B, Kamerewerd J, Sigl C, Mitterbauer R, Zadra I, Kürnsteiner H, Kück U (2010) Two components of a velvet-like complex control hyphal morphogenesis, conidiophore development and penicillin biosynthesis in Penicillium chrysogenum. Eukaryotic Cell 9: 1236-1250

Kopke K, Hoff B, Kück U (2010) Application of the yeast FLP/FRT recombinase system in filamentous fungi: Marker recycling and construction of knockout strains devoid of heterologous genes. Appl Environ Microbiol 76: 4664-4674

Hoff B, Kamerewerd J, Sigl C, Zadra I, Kück U (2010) Homologous recombination in the antibiotic producer Penicillium chrysogenum: strain ΔPcku70 shows up-regulation of genes from the HOG pathway. Appl Microbiol Biotechnol 85: 1081-1094

Kück U, Hoff B (2010) New tools for the genetic manipulation of filamentous fungi. Appl Microbiol Biotechnol 86: 51-62

Kück U, Pöggeler S (2010) Cryptic Sex in Fungi. Fungal Biol Rev 23: 55-90

Janus D, Hoff B, Kück U (2009) Evidence for Dicer-dependent RNA interference in the industrial penicillin producer Penicillium chrysogenum. Microbiology 155: 3946-3956

Kück U (2009) Mikroorganismen in den Schlagzeilen: Penicillium chrysogenum - der industrielle Produzent des ß-Lactam-Antibiotikums Penicillin. BIOspektrum

Pöggeler S, Hoff B, Kück U (2008) The asexual cephalosporin C producer Acremonium chrysogenum carries a functional mating-type locus. Appl Environ Microbiol 74: 6006-6016

Hoff B, Pöggeler S, Kück U (2008): Eighty years after its discovery Fleming’s Penicillium strain discloses the secrete of its sex. Eukaryot Cell 7: 465-470

Janus D, Hoff B, Kück U (2008): Knock-down-Systeme bei Hyphenpilzen. BIOspektrum 2/08: 169-170

Janus D, Hortschansky P, Kück U (2008): Identification of a minimal cre1 promoter sequence promoting glucose-dependent gene expression in the ß-lactam producer Acremonium chrysogenum. Curr Genet 53: 35–48

Dreyer J, Eichhorn H, Friedlin E, Kürnsteiner H, Kück U (2007): A homologue of the Aspergillus velvet gene regulates in Acremonium chrysogenum both cephalosporin C biosynthesis and hyphal fragmentation. Appl Environ Microbiol 73: 3412-3422

Janus D, Hoff B, Hofmann E, Kück U (2007): An efficient fungal RNA-silencing system using the DsRed reporter gene. Appl Environ Microbiol 73:962-970

Kück U, Hoff B (2006): Application of the nourseothricin acetytransferase gene (nat1) as dominant marker for the transformation of filamentous fungi. Fungal Genet Newslet 53: 9-11

Hoff B, Schmitt E, Kück U (2005): CPCR1, but not its interacting transcription factor AcFKH1, controles fungal arthrospore formation in Acremonium chrysogenum. Molec Microbiol 56: 1220-1233

Hoff B, Kück U (2005): Use of bimolecular fluorescence complementation to demonstrate transcription factor interaction in nuclei of living cells from the filamentous fungus Acremonium chrysogenum. Curr Genet 47: 132-138

Schmitt EK, Hoff B, Kück U (2004): AcFKH1, a novel member of the forkhead family, associates with the RFX transcription factor CPCR1 in the cephalosporin C producing fungus Acremonium chrysogenum. Gene 342: 269-281

Kück, U, Pöggeler, S (2004): pZHK2, a bi-functional transformation vector, suitable for two step gene targeting. Fungal Genet Newslet 51 :4-6

Schmitt EK, Bunse A, Janus D, Hoff B, Friedlin E, Kürnsteiner H, Kück U (2004): Winged helix transcription factor CPCR1 is involved in regulation of ß-lactam biosynthesis in the fungus Acremonium chrysogenum. Eukaryotic Cell 3: 121-134

Schmitt EK, Hoff B, Kück U (2004): Regulation of cephalosporin biosynthesis. Adv Biochem Eng Biotechnol. 88: 1-43

Schmitt E, Kück U (2002): Perspektiven zur Optimierung des pilzlichen Sekundärmetabolismus durch "Metabolic Engineering" am Beispiel der Cephalosporin C-Biosynthese. BIOspektrum 1/02: 22-27

Windhofer F, Hauck K, Catcheside D, Kück U, Kempken F (2002): Ds-like Restless deletion derivatives occur in Tolypocladium inflatum and two foreign hosts, Neurospora crassa and Penicillium chrysogenum. Fungal Genet Biol 35: 171-182

Schmitt EK, Eilinghoff B, Olliger R, Decker H, Kück U (2002): Development of molecular tools for the molundocandin producer Aspergillus sydowii: DNA-mediated transformation and reporter gene expression. Appl Microbiol Biotechnol 58: 625-631

Kürnsteiner H, Zinner M, Kück U (2001): Immunosupressants. In: HD Osiewacz (ed) THE MYCOTA X, Springer Verlag, Heidelberg, New York, Tokyo, pp 118-137

Schmitt EK, Kempken R, Kück U (2001): Functional analysis of promoter sequences from Acremonium chrysogenum: specific DNA-protein interactions and characterization of the transcription factor PACC. Molec Gen Genomics 265: 508-518

Jekosch K, Kück U (2000): Glucose repression is lost in an Acremonium chrysogenum ß-lactam producer strain and can be restored by multiple copies of the cre1 gene. Appl Microbiol Biotechnol 54: 556-563

Jekosch K, Kück U (2000): Glucose-dependent transcriptional expression of the cre1 gene in Acremonium chrysogenum strains showing different levels of cephalosporin C production. Curr Genet 37: 388-395

Schmitt EK, Kück U (2000): The fungal CPCR1 protein, which binds specifically to beta-lactam biosynthesis genes, is related to human regulatory factor X transcription factors. J Biol Chem 275/13: 9348-9357

Kempken F, Kück U (2000): Tagging of a nitrogen pathway specific regulator gene in Tolypocladium inflatum by the transposon Restless. Molec Gen Genet: 263: 302-308

Jekosch K, Kück U (1999): Codon bias in the ß-lactam producer Acremonium chrysogenum. Fungal Genetics Newsletters 46: 11-13

Kempken F, Jacobsen S, Kück U (1998): Distribution of the fungal transposon Restless: Full-length and truncated copies in closely related strains. Fungal Genet Biol 25: 110-118

Kempken F, Kück U (1998): Evidence for circular transposition intermediates from the fungal hAT transposon Restless. Curr Genet 34: 200-203

Kempken F, Kück U (1998): Transposons in mycelial fungi - facts and perspec-tives. BioEssays 20/8: 652-659

Kück U, Jacobsen S, Kempken F (1998): Activator-like transposons in Beauveria species. In: Bridge P, Couteaudier Y, Clarkson J (eds) Molecular variability of fungal pathogens. CAB International, pp 73-82

Nosek J, Radzio R, Kück U (1997): Produktion von ß-Lactamantibiotika durch Mikroorganismen - Einsatzmöglichkeiten der Gentechnik bei der biotechnolo-gischen Produktion neuer Antibiotika-Derivate. Chemie in unserer Zeit 4: 172-182

Radzio R, Kück U (1997): Efficient synthesis of the blood-coagulation inhibitor hirudin in the filamentous fungus Acremonium chrysogenum. Appl Microbiol Biotechnol 48: 58-65

Radzio R, Kück U (1997): Synthesis of biotechnologically relevant heterologous proteins in filamentous fungi. Process Biochemistry 32: 529-539

Kempken F, Kück U (1996): Restless, an active Ac-like transposon from the fungus Tolypocladium inflatum: structure, expression, and alternative RNA splicing. Mol Cell Biol 16: 6563-6572

Kempken F, Schreiner C, Schörgendorfer K, Kück U (1995): A unique repeated DNA sequence in the cyclosporin producing strain of Tolypocladium inflatum (ATCC 34921). Experimental Mycology 19: 305-313

Nowak C, Radzio R, Kück U (1995): DNA mediated transformation of a fungus employing a vector devoid of bacterial DNA sequences. Appl Microbiol Biotechnol 43: 1077-1081

Menne S, Walz M, Kück U (1994): Expression studies with the bidirectional pcbAB-pcbC promoter region from Acremonium chrysogenum using reporter gene fusions. Appl Microbiol Biotechnol 42: 57-66

Nowak C, Kück U (1994): Development of a homologous transformation system for Acremonium chrysogenum based on the ß-tubulin gene. Curr Genet 25: 34-40

Walz M, Kück U (1993): Targeted integration into the Acremonium chrysogenum genome: Disruption of the pcbC gene. Curr Genet 24: 421-427

Stimberg N, Walz M, Schörgendorfer K, Kück U (1992): Electrophoretic karyotyping from Tolypocladium inflatum and six related strains allows differentiation of morphologically similar species. Appl Microbiol Biotechnol 37: 485-489

Walz M, Kück U (1991): Polymorphic karyotypes in related Acremonium strains. Curr Genet 19: 73-76

Kück U, Walz M, Mohr G, Mracek M (1989): The 5' sequence of the isopenicillin N-synthetase gene (pcbC) from Cephalosporium acremonium directs the expression of the prokaryotic hygromycin B phosphotransferase gene (hph) in Aspergillus niger. Appl Microbiol Biotechnol 31: 358-365