Institute of Biochemistry and Pathobiochemistry

KONSTANZE F. WINKLHOFER

Chair, Dept. of Molecular Cell Biology
Institute of Biochemistry and Pathobiochemistry
Ruhr-University Bochum
Building MA 2/143
Universit├Ątsstra├če 150
44801 Bochum, Germany

Phone:   		(+49) 234 32 28428	
Secretary:  	(+49) 234 32 22428	
Fax:  		(+49) 234 32 14193	

konstanze.winklhofer@ruhr-uni-bochum.de

CELLULAR QUALITY CONTROL AND STRESS RESPONSE PATHWAYS IN NEURODEGENERATION


We are interested in neuroprotective and neurotoxic pathways that are associated with neurodegenerative diseases, such as Parkinson's, Alzheimer's and Huntington's disease. Specifically, we are focusing on the following topics:

  • Ubiquitin signaling and stress protection
  • Mechanisms to maintain mitochondrial integrity and function
  • Interorganellar communication and its role in the cellular stress response
  • Cellular quality control mechanisms to promote protein homeostasis

more...

SELECTED PUBLICATIONS


link to PubMed

Woerner et al. (2016). Cytoplasmic protein aggregates interfere with nucleo-cytoplasmic transport of protein and RNA. Science, 351(6269):173-176.

Meka et al. (2015). Parkin cooperates with GDNF/RET signaling to prevent dopaminergic neuron degeneration. J Clin Invest., 125(5): 1873-1885.

Winklhofer (2014). Parkin and mitochondrial quality control: toward assembling the puzzle. Trends Cell Biol., 24(6): 332-341.

Müller-Rischart et al. (2013). The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell, 49: 908-921.

Klein et al. (2014). Ret rescues mitochondrial morphology and muscle degeneration of Drosophila Pink1 mutants. EMBO J, 33(4): 341-55.

Rolland et al. (2013). Impaired complex IV activity in response to loss of LRPPRC function can be compensated by mitochondrial hyperfusion. Proc Natl Acad Sci U S A, 110(32): 2967-2976.