RUB » Medizin » Abteilung für Anatomie und Molekulare Embryologie

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Prof. Dr. Beate Brand-Saberi

Ruhr-Universität Bochum
Institut für Anatomie
Abteilung für Anatomie und Molekulare Embryologie

Tel.: +49 (0)234 32 27780
Fax: +49 (0)234 32 14474

e-Mail:
Beate.Brand-Saberi@rub.de


Research

The research interests of my group are in the field of developmental biology. We study cell migration, determination and differentiation of mesodermal cells, in particular of precursor cells of skeletal muscle, as well as the physiology of stem cells. Analyses are performed using chicken, zebrafish, mice and human cells.

We address questions of intercellular signalling, epigenetic control of gene expression and the activation and function of bHLH transcription factors in cell type specification.

Methods: in ovo electroporation, shRNA, In-situ-hybridization, immuno- histochemistry, confocal microscopy, live imaging, transmission electron microscopy, scanning electron microscopy, PCR, Western Blot, Microinjection

In detail we work in the following areas:

  • Cell migration during development
  • Dermis development
  • Eye development
  • Kidney development
  • Stem cell niches in development

International Collaborations

  • MD Anderson Cancer Centre in Houston
  • UT Southwestern in Dallas
  • Stowers Institute in Kansas City
  • Aarhus University, Denmark
  • Fudan University (Shanghai)
  • Shanghai JiaoTong University
  • Lanzhou University
  • Institut Pasteur, Paris
  • Institut Cochin, Paris
  • Universite Marie et Pierre Curie

Project leader in the EU’s 6th framework programme Netwok of Excellence MYORES Multiorganismic Approach to study normal and aberrant muscle development, function and repair

Other Scientific Activities

1996 - 2006 Editorial Board, Anatomy and Embryology
2004 - present Editorial Board, Am J Biochemistry and Biotechnology
1984 - present Member, Society of Developmental Biology (GfE)
1985 - present Member, Society of Histochemistry
2004 - 2008 Member of DFG Reviewers Board
2005 - present Reviewer in the 7th EU framework programme

 

Honors, Awards and Scholarships

1980 - 1981 DAAD-Scholarship University of Southampton, England
1998 Heisenberg-Scholarship of DFG
2004 Pluralistic Professor and Doctoral Tutor of Lanzhou University, Department of Life Sciences, China
2005 Guest Professor of Fudan University Shanghai
2006 Guest Professor of Shanghai JiaoTong University
2007 Forschungspreis Ersatz- und Ergänzungsmethoden zum Tierversuch des Landes Baden-Württemberg

 

Selected Publications

Chen A, Li J, Song L, Ji C, Böing M, Chen J, Brand-Saberi B (2017). GGNBP2 is necessary for testis morphology and sperm development. Scientific Reports 7, Article Number: 2998.

Brand-Saberi B, Zaehres H (2016). The development of anatomy: from macroscopic body dissections to stem cell-derived organoids. Histochem Cell Biol. 146 (6), 647-650.

Wang B, Balakrishnan-Renuka A, Napirei M, Theiss C, Brand-Saberi B (2015). Spatiotemporal expression of Math6 during mouse embryonic development. Histochem Cell Biol. 143 (6), 575-582.

Mazur AJ, Morosan-Puopolo G, Makowiecka A, Malicka-Błaszkiewicz M, Nowak D, Brand-Saberi B (2014). Analysis of gelsolin expression pattern in developing chicken embryo reveals high GSN expression level in tissues of neural crest origin. Brain Struct Funct. Doi: 10.1007/s00429-014-0923-5 [Epub ahead of print]

Lever M, Brand-Saberi B, Theiss C. (2014). Neurogenesis, gliogenesis and the developing chicken optic tectum: an immunohistochemical and ultrastructural analysis. Brain Structure and Function 219 (3), 1009-1024.

Morosan-Puopolo G, Balakrishnan-Renuka A, Yusuf F, Chen J, Dai F, Zoidl G, Lüdtke THW, Kispert A, Theiss C, Abdelsabour-Khalaf M, Brand-Saberi B. (2014). Wnt11 Is Required for Oriented Migration of Dermogenic Progenitor Cells from the Dorsomedial Lip of the Avian Dermomyotome. PLOS ONE 9(3): e92679

Pu Q, Abduelmula A, Masyuk M, Theiss C, Schwandulla D, Hans M, Patel K, Brand-Saberi B, Huang R. (2013). The dermomyotome ventrolateral lip is essential for the hypaxial myotome formation. BMC Developmental Biology, 13:37.

Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, Hoffmann MM, Morosan-Puopolo G, Yusuf F, Bisschoff IJ, Chankiewitz V, Xue J, Chen J, Ying K, Brand-Saberi, B. (2011) Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor. PLoS One 6(8):e23005

Rehimi, R., Khalida, N., Yusuf, F., Morosan-Puopolo, G., Brand-Saberi, B. (2010) A novel role of CXCR4 and SDF-1 during migration of cloacal muscle precursors. Dev. Dyn. 239(6):1622-31

Chen,J., Morosan-Puopolo, G., Dai, F. Wang, J., Brand-Saberi, B. (2010) Molecular cloning of chicken Cecr2 and its expression during chicken embryo development. Int.J. Dev Biol. 54(5):925-9

Bonnet A, Dai FP, Brand-Saberi B, Duprez D (2009) Vestigial-like 2 acts downstream of MyoD activation and is associated with skeletal muscle differentiation in chick myogenesis. Mech. Dev. 127(1-2):120-36

Hausott B; Vallant N, Yang L, Dai FP, Brand-Saberi B, Klimaschewski L (2009) Sprouty2 down-regulation promotes peripheral axon regeneration by adult sensory neurons in vitro. MCN 42(4):328-40

Zhao W., Dai F., Bonafede A., Schäfer S., Jung M., Gamel A.J.,Yusuf F., Wang J., Brand-Saberi B. (2009) Histone deacetylase inhibitor, Trichostatin A, affects gene expression patterns during morphogenesis of chick limb buds in vivo. Cells Tissues Organs 190:121-134

Rehimi R., Yusuf F., Dai F., Morosan-Puopolo G., Brand-Saberi B. (2008) Stromal-derived factor-1 alpha (SDF-1a) expression during early chick development. Int. J. Dev. Biol. 52:87-92

Bonafede, A., Köhler, T, Rodriguez-Niedenführ, M., Brand-Saberi, B. (2006) BMPs restrict the position of premuscle masses in the limb buds by influencing Tcf4 expression. Dev. Biol. 299:330-344

Yusuf, F. Rehimi, R., Morosan-Puopolo, G., Dai, F., Zhang, X., Brand-Saberi, B. (2006) Inhibitors of CXCR4 affect the migration and fate of CXCR4+ progenitors in the developing limb of chick embryos. Dev. Dyn. 235:3007-15

Weise C, Dai F, Pröls F, Ketelsen UP, Dohrmann U, Kirsch M, Brand-Saberi B. (2006) Myogenin (Myf4) upregulation in trans-differentiating fibroblasts from a congenital myopathy with arrest of myogenesis and defects of myotube formation. Anat. Embryol. 211: 639-648

Zhang, X., Dai, F., Weise, C., Yusuf, F., Bonafede, A., Morosan-Puopolo, G. Rehimi, R., Wang, J., Brand-Saberi , B. (2006) Expression of the avian Nucleolar complex associated protein2 (NOC2) - homologue in embryonic development. Anat. Embryol. 211: 649-658

Larsen, K.C., Füchtbauer, E.M., Brand-Saberi, B. (2006) The neural tube is required to maintain primary segmentation in the sclerotome. Cells Tissues Organs 182:12-21.

Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E., Birchmeier C. (2005) CXCR4 and Gab1 co-operate to control the development of migrating muscle progenitor cells. Genes and Development 19: 2187-2198.

Dai, F.P., Yusuf, F., Farjah, G.H., Brand-Saberi, B. (2005) pEGFP-vector based RNA interference for in vivo gene functional analysis in chicken embryos. Dev. Biol. 285: 80-90

Yusuf, F., Rehimi, R., Dai, F.P., Brand-Saberi, B. (2005) The expression pattern of the chemokine receptor CXCR4 in chick embryo development. Anat. Embryol. 210:35-41

Adham, I.M., Gille, M., Gamel, A.J., Reis, A., Dressel, R., Steding, G., Brand-Saberi, B., Engel, W.(2005) Pathological and genetic analysis of the scoliosis (sco) mouse: a new allele of Pax-1. Cytogenet Genome Res 111: 16-26

Ketelsen, U.P., Brand-Saberi, B., Uhlenberg, B., Wagner, M., Laberke H.G., Omran, H. Congenital myopathy with arrest of myogenesis prior fusion of myoblasts to myotubes. Neuropediatrics 36: 1-6 (2005)

Köhler, T., Pröls, F., Brand-Saberi, B. (2005) PCNA In situ hybridization: A novel and reliable tool for detection of dynamic changes in proliferative activity. Histochemistry and Cell Biology 123:315-27.

Hornik, C., Krishan, K., Yusuf, F., Scaal, M., Brand-Saberi, B. (2005) cDermo-1 misexpression induces dense dermis, feathers and scales. Dev. Biol. 277:42-50